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System
• Sensory Input
• Integration
• Homeostasis
• Mental Activity
• Control of muscles and glands
29-2
• Peripheral
Nerves
INTRODUCTION
1. Control center for all body
• Highly complex activities
system of two parts 2. Responds and adapts to changes
• Central nervous that occur both inside and outside
the body (Ex: pain, temperature)
system (CNS)
3. Detecting and interpreting sensory
information
• Peripheral
nervous system 4. Making decision about that
information and responding to and
(PNS)
carrying out motor functions.
© 2009 The McGraw-Hill Companies, Inc. All rights reserved
THE NERVOUS SYSTEM
• PNS
• CNS • Peripheral nerves
• Brain • Two sections
• Spinal cord • Somatic nervous system (SNS)
• Skeletal or voluntary muscles
• Autonomic nervous system (ANS)
• Automatic functions
29-5
29-6
dendrites direction of
cell body electrical
signal
myelin
sheath
axon
le
musc
nerve
endings
Smarter UK
APPLY YOUR KNOWLEDGE
Match the following: ANSWER:
___
B Somatic nervous system A. Motor nerves
___
C Autonomic nervous system B. Governs skeletal or voluntary muscles
___
A Afferent neuron C. Governs respiratory and GI systems
___
E Efferent neuron D. Go-betweens or interpreters
___ Interneurons E. Sensory nerves
D
29-8
What is this in
The synapse - where
the membrane?
the action happens
Transport
The next cell’s plasma
protein
membrane
The synapse carries a signal from cell to cell
3 4
2
Communication Between
Neurons
- The use of
neurotransmitters
causes an
electrical current
There is enough
electrical current
in the brain to
power a
flashlight
• Functional cells of NS
• Transmit electrochemical
messages called nerve impulses
to
• Other neurons
• Effectors (muscles or glands)
29-21
myelin sheath
cell body
nucleus
axon
structure of a neurone
Smarter UK
neuronescommunicate with each other using a
mixture of electrical & chemical signals
cell body
nucleus an electrical
signal is
transmitted
along the axon
axon
Smarter UK
signals cross between neurones at the synapse
synapse
Smarter UK
1 electrical impulse triggers vesicles signals cross between neurones at the synapse
to move to the synapse membrane
vesicles fuse with the membrane and synapse
2 release neurotransmitter into the synaptic
cleft nerve endings
dendrites
neurotransmitter diffuses across vesicle
3
the cleft and binds to receptors on myelin sheath
the other side
Smarter UK
The point where your muscles and nervous system meet is called the
le
musc
Smarter UK
NERVE IMPULSE
• Membrane potential
• Neuron cell membrane at rest is in a polarized state
• Inside of cell membrane is negative
• Outside of cell membrane is positive due to more Na + and K+
• As Na+ and K+ move into the cell, the membrane becomes
depolarized
• Inside becomes more positive
• Action potential (nerve impulse) is created
• Repolarization occurs when K+ and later Na+ move to the outside of
the cell membrane 29-34
• Return of the cell to polarized (resting) state
© 2009 The McGraw-Hill Companies, Inc. All rights reserved
NERVE IMPULSE (CONT.)
• Impulse travels down axon to synaptic knob
• Vesicles or small sacs in synaptic knob
• Produce chemicals called neurotransmitters
29-35
• Functions of neurotransmitters
• Cause muscles to contract or relax
Right! 29-37
29-39
• Epidural space
• Above dura mater
• Subdural space
• Below dura mater
• Subarachnoid space
• Between arachnoid mater and pia mater
• Contains cerebrospinal fluid (CSF)
• Cushions CNS
29-41
-Learning occurs as
more and stronger
connections are
made between
neurons
Cerebrum : largest
part of human brain
- Responsible for:
- Thought
- Language
- Senses
- Memory
- Voluntary
movement
CNS: BRAIN – CEREBRUM
• Largest section
• Two cerebral hemispheres
• Connected by a thick bundle of nerve fibers called the corpus
callosum
• Longitudinal fissure between hemispheres
Brain
29-45
• Location
• Inferior to the occipital lobes of the cerebrum
• Posterior to the pons and medulla oblongata
• Coordinates
• Complex skeletal muscle contractions that are needed for body movements
• Fine movements
Brain
29-50
Brain
29-51
Brain stem
regulates heart
rate, breathing, Cerebellum
Smarter UK
Brain Teaser
AHIMNOTUVW
Which of the letters above does not belong with the rest?
- Responsible for:
- Conducting
impulses between the
brain and the rest of
the body
• 31 Spinal segments:
• 8 cervical segments
• 12 thoracic segments
• 5 lumbar segments
• 5 sacral segments
• 1 coccygeal segment 29-59
• Cervical enlargement
• Motor neurons that control
muscles of the arms
• Lumbar enlargement
• Motor neurons that control
muscles of the legs
29-60
• Central canal runs down the entire length of the spinal cord through
the center of the gray matter
Spinal
Cord/Nerve
29-61
• White matter
• Outer tissue
• Contains myelinated axons
• Divisions are called columns (funiculi)
• Columns contain groups of axons called nerve tracts
Spinal
Cord/Nerve 29-62
• Ascending tracts
• Carry sensory information up to the brain
• Descending tracts
• Carry motor information down from the brain to muscles
and glands
29-64
• Peripheral nerves
• Two types:
• Cranial nerves
• Spinal nerves
29-68
Nerves : visible
bundles of axons
and dendrites that
extend from the
brain and spinal
cord to all other
parts of the body
-Responsibilities:
- Sensory nerves -
carry messages
from body to brain
(pain, pressure,
temperature)
- Motor nerves –
carry messages
from brain to body
to respond
PNS: CRANIAL NERVES
I. Olfactory nerves
• Carry smell information to the brain for interpretation
III. Oculomotor nerves
• Found within the muscles that move the eyeball, eyelid,
and iris
V. Trigeminal nerves
• Carry sensory information from the surface of the eye, the scalp,
facial skin, the lining of the gums, and the palate to the brain for
interpretation
• Also found within the muscles needed for chewing
VI. Abducens nerves
• Act in the muscles that move the eyeball
29-72
29-73
X. Vagus nerves
• Carry sensory information from the thoracic and abdominal organs
to the brain for interpretation
• Also found within the muscles in the throat, stomach, intestines, and
heart
29-74
29-75
• Dermatome
• Skin segment innervated by spinal nerve
• C1 is not associated with a dermatome
• Ventral root
• Axons of motor neurons only
• Dorsal root
• Axons of sensory neurons only
• Dorsal root ganglion
• Contains cell bodies of sensory neurons
29-77
Spinal
Nerves 29-78
29-80
29-81
• Sympathetic division
• “Fight or flight” – Prepares body for stressful or emergency situations
• Neurons release neurotransmitter norepinephrine
• Increases heart and breathing rates
• Slows down muscles of the stomach and intestines
• Dilates pupils
• Constricts blood vessels – increases blood pressure
29-82
• Parasympathetic division
• Prepares body for rest and digesting
• Controls most of the body’s organs
• Releases acetylcholine
• Slows heart and breathing rates
• Constricts pupils
• Activates muscles of stomach and intestine
• No communication with blood vessels
29-85
• Cerebral angiography
29-86
• Hyporeflexia
• Decreased reflex
• Hyperreflexia
• Stronger-than-normal reflex 29-89
• Knee reflex
• Absence may indicate damage to lumbar or femoral nerves
• Abdominal reflexes
• Used to evaluate damage to thoracic spinal nerves
29-90
29-91
About how many neurons are in the human brain? 100 billion
How long do you think the longest axon in the world is? around 15 feet
How many synapses
are in one neuron?
1,000 to 10,000!!
What do you think can change neurons and their
connections?
• Accidents
• Drugs
• Alcohol
• Disease
Accidents
• Physical injury of your neurons
Drugs and alcohol bind important receptors on neurons
Repeated binding causes the neuron to die
Drugs = neuron death
Alcohol damages dendrites - can
repair after abstinence
Alcohol blocks
receptors and slows
down transmission
• Parkinson's Disease
• ALS - Lou Gehrig’s Disease
• Huntington’s Disease
• Multiple Sclerosis
• Alzheimer's
• Cerebral Palsy
• Epilepsy
• ? SIDS
Epilepsy
Abnormal
transmission of
messages
between the
neurons in the
brain
Symptoms:
seizures
COMMON DISEASES AND DISORDERS
Disease/Disorder Description
Alzheimer’s Progressive, degenerative disease of
disease the brain
Amyotrophic Lou Gehrig’s disease
lateral sclerosis Degeneration of neurons in the spinal
(ALS) cord and brain
Bell’s palsy Weak or paralyzed facial muscles
29-103
Disease/Disorder Description
Brain tumors and Abnormal growths
cancers Can be primary or secondary tumors
Most common – gliomas
Epilepsy and Occurs as a result of bursts of
seizures electrical signals that disrupt normal
brain functioning
Guillain-Barré Body’s immune system attacks the
Syndrome PNS
29-104
Disease/Disorder Description
Headaches
Tension Episodic or chronic
Migraines With aura/without aura
Cluster Form of migraines; occurs in groups
Meningitis Inflammation of meninges
Multiple Chronic disease of CNS
sclerosis (MS) Myelin is destroyed
29-105
Disease/Disorder Description
Neuralgias Disorders causing nerve pain
Parkinson’s Progressive and degenerative motor
disease system disorder
Sciatica Damage to sciatic nerve
Stroke Brain cells die because of an
inadequate blood flow; “brain attack”
29-106
Red areas
show where
chemical is
stored
Alzheimer’s Disease
A gradual shrinking
of the neurons in
the cerebrum
Symptoms: memory
loss, emotional
disturbances,
inability to
function on own,
death
APPLY YOUR KNOWLEDGE
your brain
learns and
forms
memories by
strengthening