Professional Documents
Culture Documents
Water
Good for Pharmaceutical
Manufacturing Practice Use
Deadleg section
X <2D
If D=25mm & distance X is
greater than 50mm, we have
a dead leg that is too long.
Sanitary Valve
Water scours deadleg
1. Sanitary pumps
3. Heat exchangers
4. Side arm level measuring devices are
unacceptable
6 6
5 5
4 4
3 3
2 2
1 1
Water
must be Cationic column Anionic column Cartridge Cartridge
filter 5 µm filter 1 µm
kept UV light
circulating Eluates to
neutralization
Ozone generator
plant
Hygienic pump
Return to de-ioniser
Outlets or storage.
Drain line
Bead diameter:
300 to 1200 µm
(0.3 to 1.2 mm)
Beads pores:
1 to 100 nm
(0.001 to 0.1 µm)
Fixed Anion
Counter Cation
Styrene
(DVB)
Hydrating Water
Osmotic P
pressure
1 2 1 2
Reverse osmosis
1 Feed water membrane (RO)
2 Purified water
Semi-permeable
membrane
Feed
water
Permeate
Reject
water
water
drain or recycle
Reject
Second stage reject water goes back to first stage buffer tank
1st stage buffer tank
Branch First stage RO cartridge
1st stage reject concentrate
Branch
Air break
to sewer 2nd stage buffer tank
Second stage RO cartridge
High pressure
pump
Cartridge
filter 1 µm Hygienic pump
Second stage RO water
meets Pharmacopoeia Water returns to 1st stage buffer tank
standards Outlets or storage
100
circulating
UV light
Outlets
Heat Exchanger
Ozone Generator Hygienic pump Air break
to drain
Ultraviolet radiation
Relative
intensity
Wavelength
(nm)
185 254 313
Emission of a low pressure mercury lamp.
100%
80%
60% 254nm
40%
20%
0%
240 260 280 300 320
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