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    The study investigated the relationship between threatened miscarriage and gestational diabetes mellitus (GDM). It analyzed data from over 1,500 pregnant women in Korea, including those with threatened miscarriage, GDM, or normal pregnancies. The results showed threatened miscarriage was associated with a decreased risk of GDM and less severe glucose intolerance levels. Further research is still needed to understand the pathophysiological mechanisms linking threatened miscarriage and GDM risk.

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    dm gestatsional

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    DM pada kehamilan

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    The study investigated the relationship between threatened miscarriage and gestational diabetes mellitus (GDM). It analyzed data from over 1,500 pregnant women in Korea, including those with threatened miscarriage, GDM, or normal pregnancies. The results showed threatened miscarriage was associated with a decreased risk of GDM and less severe glucose intolerance levels. Further research is still needed to understand the pathophysiological mechanisms linking threatened miscarriage and GDM risk.

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    1 views20 pages

    DM Pada Kehamilan

    Uploaded by

    asumaacoco
    The study investigated the relationship between threatened miscarriage and gestational diabetes mellitus (GDM). It analyzed data from over 1,500 pregnant women in Korea, including those with threatened miscarriage, GDM, or normal pregnancies. The results showed threatened miscarriage was associated with a decreased risk of GDM and less severe glucose intolerance levels. Further research is still needed to understand the pathophysiological mechanisms linking threatened miscarriage and GDM risk.

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    of 20

    RELATIONSHIP BETWEEN THREATENED

    MISCARRIAGE AND GESTATIONAL


    DIABETES MELITUS
    Hee Joong Lee, Errol Norwitz and Banghyun Lee

    Preceptor :
    dr. Yusrizal, Sp.OG
    Presented by:
    Muhammad Riza Qadafi, S.Ked

    FACULTY OF MEDICINE
    JOURNAL
    ABULYATAMA UNIVERSITY
    READING MEURAXA HOSPITAL
    BACKGROUND

    Uteroplacental vessels
    Considered to be
    The most cause of
    Vaginal bleeding

    Threatened miscarriage occurs


    In an estimated 14-20% of all pregnant woman
    JOURNAL
    READING
    MATERNAL
    HYPERGLYCEMIA

    Inadequate for the increase


    insulin requirements during
    pregnancy
    JOURNAL
    READING
    PROGESTERONE

    Hypothesis :
    Women with threatened miscarriage may have less insulin
    resistance during the secong and third trimester of pregnancy

    JOURNAL
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    So, what is the purpose of the study?

    • To investigate whether threatened


    miscarriage is a risk factor for GDM and

    • To evaluate this relationship according to


    the severity of glucose intolerance

    JOURNAL
    READING
    METHODS

    Seoul or Uijeongbu
    Data Source St. Mary’s Hospital at the Catholic
    University of Korea

    Periode

    January 1, 2006 - October 31, 2013

    JOURNAL
    READING
    METHODS

    Inclusion Pregnant women who underwent a two-step approach to diagnose


    Criteria GDM

    • Women who did not undergo a 100-g OGTT after a positive 50-g
    OGCT
    Exclusion • Who had other causes of vaginal bleeding
    • Fetal anomalies
    Criteria • Multifetal gestation
    • Overt DM
    • Non – Korean ethnicity

    JOURNAL
    READING
    METHODS
    OGTT
    Inclusion
    Criteria OGCT

    √
     
    Exclusion
    OGTT OGCT Fetal anomalies
    Criteria

    JOURNAL
    READING
    The routine protocol
    To diagnose GDM
    OGTT Plasma glucose level >7,8 mmol/L
    100-g At 1-h post glucose load without prior fasting

    • Fasting glucose of ≥ 5,3 mmol/L


    OGCT • ≥ 2 plasma glucose
    • 1-h glucose of ≥ 10,0 mmol/L
    measurements greater
    50-g • 2-h glucose of ≥ 8,6 mmol/L
    than following
    • 3-h glucose ≥ 7,8 mmol/L

    • OGCT = positif
    Borderline • OGTT = negatif
    JOURNAL
    READING
    1567
    Gestasional age
    • Diet control 247 840
    • Exercise GDM Normal Last menstrual Crown-rump
    • Careful glucose 480 period (LMP) Length (CRL)
    monitoring Border
    • line

    Amount of bleeding
    Same routine as
    healthy pregnant
    woman

    light heavy

    JOURNAL
    READING
    Intrauterine Crescent-shaped
    Hematom echolucent

    SGA <10
    persentil

    AGA 10 – 90
    BMI persentil

    LGA > 90 persentil

    JOURNAL
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    RESULT
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    Discussion

    GDM Decreased in GDM


    Miscarriage

    The birth weight and the incidence rate of


    Inverse correlation SGA, LGA, or macrosomia were ubchanged
    in women with GDM and maternal
    hyperglycemia

    JOURNAL
    READING
    CONCLUSION :

    This study demonstrate


    That miscarriage is associated with decreased risk of
    GDM and the severity of glucose intolerance in korean
    women. Additional studies are warranted to understand the
    pathophysiologic mechanisms that might exist between these
    frequent complications of pregnancy

    JOURNAL
    READING

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