CORRELATION SEMINAR ON

CARDIOVASCULAR SYSTEM

Name: Nischal Neupane

MBBS 38th Batch
Roll Number: 1836
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 OBJECTIVES

1. To name the organs involved in the

reticuloendothelial system
2. To describe the role of bone marrow
3. To correlate it with megaloblastic
anaemia

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 RETICULOENDOTHELIAL SYSTEM
+ Group of cells having ability to take up and
sequester inert particles and vital dyes
+ Includes macrophage and macrophage precursors
+ Includes reticular cells of lymphatic tissue ie
macrophages and of bone marrow ie fibroblasts
+ Includes specialized endothelial cells lining sinusoids
of liver, spleen and bone marrow.

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 CONTINUED

+ Reticuloendothelial system now better known

as
1. Monocyte macrophage system
2. Macrophage system
3. Monocyte phagocyte system
4. Monocyte phagocytic system

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 ORGANS INVOLVED
In the form of monocytes In the form of macrophages
1. Bone marrow 1. Spleen
2. Blood 2. Liver
3. lymphnode
4. Central nervous system
5. Skin
6. Lungs
7. Skin
8. Mucosal cells
9. Connective tissues
10. Bone
11. cartilage 5
 DIFFERENT NAMES IN
DIFFERENT ORGANS
•liver-kupffer cells or stellate macrophage or kupffer-Browicz
cells-liver sinusoids

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 CONTINUED
•Splenic macrophages
a) Marginal metallophilic macrophages
b) Marginal zone macrophages
c) Red pulp
d) White pulp

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 CONTINUED
• Lymph node-LN macrophages
a) Sub capsular sinus macrophages
b) Medullary sinus macrophages
c) Medullary cord macrophages

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 CONTINUED
• Central nervous system
a) Microglial cells
b) Perivascular macrophages
c) Meningeal macrophages
d) Choroid plexus macrophages

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 CONTINUED
• Macrophages of lungs-dust cells

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 CONTINUED
• Macrophage of connective tissues-histiocytes

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 CONTINUED
• Macrophage of bone cartilage kidney

Osteoclast chondroclast Mesangial cells

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 CONTINUED
• Macrophage of skin Intestine
Langerhans cells
Intestinal macrophages

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 BONE MARROW
+ Are special semisolid tissues found in
medullary cavities of bones
+ Are primary lymphoid organs
+ Hematopoietic organ
+ Two types
1. Red bone marrow
2. Yellow bone marrow

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 CONTINUED

Liver- 3rd month

Yolk sac- 3rd week

Bone marrow- 4th month At birth-100% active

Until puberty
At 18 years-50% active

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CONTINUED

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 ROLE OF BONE MARROW
+ Active hematopoietic organ
+ Pleuripotent hematopoietic stem cell
+ Precursor of all blood cells
+ Myeloid and lymphoid progenitors
+ Granulocyte-Monocyte, erythrocytes and
megakaryocyte
+ T lymphocytes, B lymphocytes and NK(natural
killer) cells

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 CORRELATION WITH
MEGALOBLASTIC ANEMIA
+ Bone marrow hyperplasia
+ Ineffective hematopoiesis
+ Pancytopenia
+ Megaloblastic changes of erythroid precursors
+ Large magakaryocytes

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 BIBLIOGRAPHY
1. Dorland’s Illustrated Medical Dictionary-32nd
edition
2. Wheater’s functional Histology-6th edition
3. Robbins and Cotrans pathological basis of disease,
South Asia Edition
4. www.ncbi.nlm.nih.gov/pmc/articles/PMC4585205/
5. www.ncbi.nlm.nih.gov/pmc/articles/PMC3742955/
6. www.ncbi.nlm.nih.gov/pmc/articles/PMC3574571/

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One world One home
Thank you

Lets Be Caring, And Care For Heart

One Heart
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