DD

Sindrom Nefrotik Diabetus Melitus Type 2 Dyslipidemia

Definisi penyakit glomerular yang ditandai Diabetes Mellitus Type 2 is a metabolic Abnormalities in lipid
dengan edema, proteinuria masif disorder characterized by an increase in metabolism characterized by
>3,5 gram/hari, hipoalbunemia. an increase or decrease in the
lipid
Epidemiologi • <6 tahun • Obesity (overweight) • Obesity
• MCD pediatrik 70% • Hypertension • Diabetes melitus
• AS & Inggris 12 – 16 kasus per • Family History of Diabetes Mellitus • A diet high un saturated fat
100.000 anak • Dyslipedimia • Age
• Indonesia 6 per 100.000 per • Age
• Factor Genetik
tahun pada anak >14 tahun • Alcohol and Cigarettes
• Anak laki-laki dan perempuan
2:1
Etiologi • Kongenital
• Primer
• Sekunder

• Kodner C.: Diagnosis and management of nephrotic syndrome in adults. Am Fam Physician 2016; 93 (6): pp. 479-485. Di
https://www.clinicalkey.com/#!/content/derived_clinical_overview/76-s2.0-B9780323755702006317#hl0000378
Pathophysiology Sindrom Nefrotik

Kodner C.: Diagnosis and

management of nephrotic
syndrome in adults. Am Fam
Physician 2016; 93 (6): pp. 479-
485. Di
https://www.clinicalkey.com/#!/c
ontent/derived_clinical_overvie
w/76-s2.0-B9780323755702006
317#hl0000378
• Decroli E. 2019. Diabetes Miletus Tipe 2. Pusat Penerbitan Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Andalas: Padang.
• Farimah RN. 2015. Diabetes Miletus Tipe 2. J MAJORITY. 5(4).
• Materi kuliah Prof. Dr. dr. Harsinen, Sp. PD, KEMD. 2021. DM Tipe 1 dan DM Tipe 2.
Pathophysiology of Obesity with Dyslipidemia
People who are obese and have a high-fat diet (especially animal fats)

Causes increased synthesis of cholesterol in the liver

LDL concentration increases

LDL binds to scavenger receptors, which are intermediate receptors for collecting
cholesterol in macrophages, skin and blood vessels

Causes the accumulation of cholesterol in macrophage cells, skin and blood vessels

Triggering the occurrence of atorsclerosis and coronary heart disease

 Sindrom Nefrotik Diabetus Melitus Type 2 Dyslipidemia
Diagnosis • Klinis: edema progresif -polyuria, polydipsia, polyphagia, • Secondary dyslipidemia is generally
ekstremitas bawah, >>berat unexplained weight loss. not accompanied by symptoms and
badan dan lemah, urin berbusa, -weakness signs
pretibial edema, edema -. • primary dyslipidemia may show
periorbita, edema skrotum, several signs associated with an
edema anasarka, ascites. extreme increase in cholesterol
• Pem. Penunjang: Urinalisis dan levels
biakan urin, pem. Darah,
radiologi, histopatologi
Tatalaksana • Non-farmako: Manajemen Nutrisi -Typical complaints and symptoms History: In the history, it is necessary
dan Cairan -The results of blood glucose tests, to look for atherosclerotic risk factors
• Farmakologis: Diuretik, ACE then a standard oral glucose
inhibitor, Kortikosteroid, Terapi tolerance test (TTGO) can be Physical ecamination: evaluate blood
Hiperlipidemia, Antibiotik, followed. pressure, profile
Antikoagulan

• Partini dkk. 2012. TATA LAKSANA SINDROM NEFROTIK IDIOPATIK PADA ANAK. Unit Kerja Koordinasi Nefrologi Ikatan Dokter Anak Indonesia: Badan Penerbit Ikatan Dokter Anak
Indonesia di https://spesialis1.ika.fk.unair.ac.id/wp-content/uploads/2017/03/Konsensus-Tata-Laksana-Sindrom-Nefrotik-Idiopatik-Pada-Anak.pdf
 DD
Sindrom Nefrotik Diabetus Melitus Type 2 Dyslipidemia
Komplikasi • Keseimbangan Nitrogen Negatif • Diet Non pharmacologi:
• Hiperkoagulasi • Exercise (physical exercise / sports) • screening, initial nutritional
• Hiperlidemia dan lipiduria • Health Education evaluation and dietary
• Infeksi organisme berkapsul, • Medication: oral hypoglycemic, insulin habits
defek imunitas humoral, seluler • education to reduce total
dan gangguan sistema and saturated fat intake
komplemen. • Physical activity
Prognosis Bergantung dari penyebab dasarnya,
pemeriksaan histologi dan faktor
risiko dari pasien

• Gusti Ayu. 2019. SINDROM NEFROTIK. Universitas Udayana di http://erepo.unud.ac.id/id/eprint/34551/1/7157d58fef5673ce0c85758769f1232e.pdf