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  • Riyadh 06

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    ral
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    This document discusses serotonin and norepinephrine modulation in the brain. It shows how serotonin from raphé neurons inhibits norepinephrine release from locus coeruleus neurons via 5-HT1A receptors. It also depicts how acute and chronic treatment with selective serotonin reuptake inhibitors or norepinephrine reuptake inhibitors can impact neurotransmission of these neurotransmitters. Finally, it outlines different antidepressant strategies and their mechanisms of action, such as increasing serotonin levels through monoamine oxidase inhibitors or selective serotonin reuptake inhibitors.

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    Riyadh06

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    This document discusses serotonin and norepinephrine modulation in the brain. It shows how serotonin from raphé neurons inhibits norepinephrine release from locus coeruleus neurons via 5-HT1A receptors. It also depicts how acute and chronic treatment with selective serotonin reuptake inhibitors or norepinephrine reuptake inhibitors can impact neurotransmission of these neurotransmitters. Finally, it outlines different antidepressant strategies and their mechanisms of action, such as increasing serotonin levels through monoamine oxidase inhibitors or selective serotonin reuptake inhibitors.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
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    3 views5 pages

    Riyadh 06

    Uploaded by

    ral
    This document discusses serotonin and norepinephrine modulation in the brain. It shows how serotonin from raphé neurons inhibits norepinephrine release from locus coeruleus neurons via 5-HT1A receptors. It also depicts how acute and chronic treatment with selective serotonin reuptake inhibitors or norepinephrine reuptake inhibitors can impact neurotransmission of these neurotransmitters. Finally, it outlines different antidepressant strategies and their mechanisms of action, such as increasing serotonin levels through monoamine oxidase inhibitors or selective serotonin reuptake inhibitors.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
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    of 5

    5-H

    ?
    T2 A
    Locus
    5-HT

    2 Coeruleus
    (-) (-)

    Raphe

    5-HT   2
    (+)
    1
    (-)

    T 1A

    5- H

    2
    (-)
    2

    1

    1

    (-)
    5-HT
    (+)
    T 1A

    5-H
    Postsynaptic
    (-)

    Neuron
    Serotonin modulation of NE neuron firing
    in the locus coeruleus
    GABA GABAA
    (+)
    5-HT 5-HT2A

    GABA
    (+)
    5-HT2A (-)

    5-HT1A GLU
    GLU

    5-HT (-)

    5-HT1A

    2A
    NE
    5-HT1A

    GLU (-)
    NE neurotransmission and NE reuptake inhibition

    normal

    acute treatment with a


    NE reuptake blocker

    long-term treatment with a


    NE reuptake blocker
    5-HT transmission and 5-HT reuptake inhibition

    normal

    acute treatment with a


    SSRI

    long-term treatment with a


    SSRI
    Actions of Antidepressant Strategies
    5-HT Neuron Postsynaptic
    Neuron
    MAOI
    SSRI

    Tryptophan
    MAO
    5-HT4

    7
    TH
    5-HT

    5-
    5-HT

    5-HT1A
    (+)
    1A

    5-HT1B
    HT

    5-HT1A

    T3
    5-

    Lithium

    5-H
    5-HT
    2
    (+)
    (+)

    (-)

    Buspirone
    Pindolol
    Tryptophan
    T3

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