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ORGANISMS MAINTAIN
STEADY INTERNAL
CONDITIONS THAT POSSES
VARIOUS STRUCTURES AND
PROCESSES
Through Homeostasis and Feedback Mechanism
B. Thermoregulation in Plants:
1. Ripening of fruits
2. In most plants, this process is driven by sunlight – acting as
a positive feedback mechanism to hold the stoma open.
3. Droughts become more intense due to
a positive feedback loop. When there isn’t enough
rain, plants die off, which limits how much water vapor is
added to the air from the planet’s surface.
Negative Feedback Mechanism in Plants
NEGATIVE FEEDBACK
1. Stimulation
The first step in the positive feedback loop is the stimulation that sets off
the loop in order to complete a process.
The stimuli in the human body are mostly hormones released by different
organs as a result of the initiation of a process.
An example of a stimulus that initiates a positive feedback mechanism is
the contraction during childbirth.
2. Reception
The second step in the loop is the reception of
the stimuli through different sensors that send
the information to the control unit.
These receptors are mostly nerves that send
the signal from the site of stimulus to the
control unit, which in humans is the brain.
3. Processing
The next step in the loop is the processing of
information sent to the control unit by the receptors.
The control unit tallies the information to check if the
stimulus is outside the normal range of the value and
presents an output.
In the case of childbirth, the brain receives
information about the contractions in the uterine wall
and then stimulates the secretion of the hormone
oxytocin by the pituitary gland.
4. Further activation of the stimuli
The information from the brain is sent to the site of action via
different nerves in order to induce an output in response to
the stimulus.
In the case of the positive feedback loop, the signals from the
brain tend to activate the stimulus even further in the
direction of deviation.
The stimulation of the pituitary gland to release oxytocin,
which further increases the contractions of muscles in the
uterine wall during childbirth is an example of this process.
Examples of Positive Feedback Mechanism
1. Menstrual cycle
At the beginning of the menstrual cycle, the ovaries release
the hormone estrogen. The estrogen acts as a stimulus for the
positive feedback loop.
The information is sent to the brain, which then stimulates the
release of gonadotrophin-releasing hormone from the
hypothalamus and luteinizing hormone from the pituitary.
The release of follicle-stimulating hormone finally results in
ovulation, and eventually, the menstrual cycle begins.
This is an example of a positive feedback mechanism as the
increase in one factor induces the movement of the output in
the same direction until the task is completed
2. Childbirth
Normal childbirth is driven by a positive feedback loop. A positive
feedback loop results in a change in the body’s status, rather than
a return to homeostasis.
Positive feedback mechanism in humans is also observed during
childbirth which is induced by the pressing of the ovarian wall
by the baby.
The pressing sensation is passed to the brain via different
nerves, and in response, the brain stimulates the pituitary to
produce oxytocin.
Oxytocin is responsible for the contractions of the uterine
muscles which cause the movement of the fetus towards the
cervix, further increasing the stimulus.
The positive feedback loop continues until the baby is born.
Steps / Process / Mechanism of Negative Feedback
Mechanism
1. Stimulation
The first step of the negative feedback loop is the generation
of stimuli as a result of the deviation of physiological
parameters from the normal value. The deviation of
physiological parameters can occur at either extreme.
The deviation might either require the activation or
inhibition of different physiological activities of the body
to maintain the normal state.
The most common and easily understood stimulus is the
change in body temperature away from the normal limit.
2. Reception
The changes in the physiological parameters are received by
the control unit via different receptors present in different
parts of the body.
Some of the common receptors involved in the transmission
of stimulus include nerves and other thermoreceptors.
3. Processing
The control unit of the loop is the brain which first determines if the
change in the physiological parameter requires activation of inhibition
of the loop.
Depending on the direction of deviation, the brain sends out signals to
undo the changes via different mechanisms.
In the case of changes in body temperature, the group of cells in the
hypothalamus of the brain acts as the control unit.
4. Counteract on the stimulus
As the final step of the loop, the control unit sends out signals to
nullify the effects causing changes in the physiological factors.
The changes can be of different types and directed towards
different parts of the body. The information is sent to different
organs via the nervous system.
In the case of a decrease in body temperature, the hypothalamus
sends out signals resulting in shivering, constriction of blood
vessels, and behavioral changes like curling up.
These activities result in an increase in body temperature, which
then inhibits the loop, and the process is complete until the body
temperature decreases again.
Examples of Negative Feedback Mechanism
1. Regulation of blood glucose level
The level of glucose in the blood is controlled by a negative
feedback mechanism.
If the blood glucose level increases beyond the normal range, more
glucose is absorbed in the intestine and stored in the form of
glycogen in the liver.
The conversion and conservation are controlled by the release of
insulin from the pancreas. The hormone insulin stimulates the
muscles and liver to uptake the glucose.
If the blood glucose level decreases and more glucose is required in
the blood, the release of insulin is inhibited, reducing the
absorption of blood glucose.
2. Temperature regulation
Regulation of body temperature by endotherms is another classic
example of a negative feedback mechanism in the human body.
When the temperature of the body increases beyond normal, the
brain signals different organs of the body like the skin to release
heat in the form of sweat.
These physiological activities eventually the temperature to drop
down to a point where the pathways of the negative feedback
mechanism shut down.
A similar process occurs if the body temperature increases beyond
the normal value in order to maintain homeostasis.
Quiz
1. Which of the following represents negative
feedback?
A. Blood platelets release chemicals that attract more blood
platelets when then fill a wound
B. One bird fleeing a predator spurs three birds, which in turn
scares the whole flock
C. In producing an amino acid, the enzyme a cell uses is
inhibited after the amino acid reaches a specific concentration
C is correct. The first two systems represent positive feedback.
As a few individuals start to react, many more are encouraged to
react. These systems result in reactions that go to completion in
one direction. For example, the entire flock will fly away or the
entire wound will be sealed. In the third case, the product
regulates the pathway. This means that the cell will not expend
too much energy and will produce just the right amount of the
product it needs.
2. Bees control the temperature of their hive in an
interesting way. When the temperature gets too hot,
certain bees release a signal to the rest of the colony to
begin a specific behavior. The bees evaporate water from
their mouths and fan their wings to significantly decrease
the temperature. As it cools, the colony resumes its normal
activities. Which of the following terms describes this
scenario?
A. Positive Feedback
B. Negative Feedback
C. Enzyme Inhibition
B is correct. This is an example of negative feedback. The stimulus
produces a reaction in the bees which lowers the stimulus. In turn,
the pathway is eventually shut off. Remember that feedback
mechanisms can be a part of systems of all sizes, from chemical
pathways to the activities of entire groups of organisms.
3. You are reaching into a hot stove to grab your dinner.
Your finger slips off the hot pad, and touches the scalding
hot dish in the oven. A signal is sent to your brain, which
tells your arm to contract. When your finger stops burning,
your arm can relax. What does this scenario represent?
A. Negative Feedback
B. Positive Feedback
C. Fight or Flight response
A is correct. Again, the stimulus that caused the reaction is
removed through the process. This is negative feedback. The
fight or flight response may be involved, but remember that
even these processes must be controlled by some form of
feedback, or else they would continue forever. The negative
feedback mechanism allows the system to reset after a
stimulus, which at the cellular level allows for preparation for
another stimulus to react to.