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Chorion frondosum

Decidua
basalis

Chorionic
plate

Chorion leave
Dr. Sherif Fahmy
Gastrulation
Gastrulation

2- Primitive node.
3- Bucco-pharyngeal membrane.
4- Cloacal membrane.
Syncytiotrophoblast
Amniotic Yolk sac
cavity

Cytotrophoblast Buccopharyngeal
membrane
Somatic extra-
embryonic
mesoderm

Primitive
node & pit

Primitive
streak

Hypoblast
Cloacal Epiblast
Dr. Sherif Fahmy
membrane
Invagination
- Epiblast cells migrate to primitive streak.
-Then they pass beneath epiblast to become
flask-shaped and separated from the epiblast and
form:
1- Endoderm that replaces the hypoblast.
2- Third layer between epiblast and endoderm
which consists of intra-embryonic mesoderm
with notochord in the median region..
3- Remaining epiblast cells after formation of
notchord and intraembryonic mesoderm will be
named ectoderm.
Primitive node and pit
Primitive streak

Epiblast

Hypoblast

Invaginating cells from epiblast lyaer


Amniotic cavity

Embryonic disc
Connecting
stalk

Secondary yolk sac Primitive


streak
Notochord under
ectoderm Cloacal
membrane

Dr. Sherif Fahmy

Connecting
stalk

Amniotic cavity
Buccopharyngeal
Primitive pit
Dr. Sherif Fahmy
membrane
1-Notochordal Connecting
Primitive
process stalk
pit
Primitive
streak
Epiblast
Amniotic
cavity

Endoderm that Allantois


Bucco-pharyngeal replaced hypoblast
membrane Secondary
yolk sac
Notochordal
process Primitive streak

Connecting
stalk

Allantois

2-Notochordal
canal
Buccopharyngea
l membrane

Cloacal membrane

Dr. Sherif Fahmy


Allantois

2-Notochordal
canal
Amniotic cavity

Roof of notochordal canal

Yolk
sac

3-Degenerating endoderm and floor of notochordal


Neurenteric canal

Dr. Sherif Fahmy

Cloacal
membrane
Buccopharyngea
l membrane
Extraembryonic
Notochordal
mesoderm
Epiblast canal
(Ectoderm)

Dr. Sherif Fahmy

Endoderm
Intraembryonic
mesoderm
Notochordal
plate

Dr. Sherif Fahmy

Notochordal plate (roof


of the canal intercalate
(fixed) to endodermal
layer.
Dr. Sherif Fahmy
Dr. Sherif Fahmy

Notochord
• 1- Pre-notochordal process: Proliferation of cells from
primitive pit forms a cord of cells in median plane till
prochordal plate.
• 2- Notochordal canal: Canalization of the process forms
notochordal canal.
• 3- Notochordal-ectodermal fusion: fusion between floor of
the canal and endoderm.


Fate of Notochord
• It is the primitive axial skeleton around which
the vertebral column is formed.
• It remains in intervertebral disc as nucleus
pulposus.
Dr. Sherif Fahmy

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