Mass Balance – Coecervate Stage

Components Nomenclature Unit Lab Exp.

Polymer, p g 15
DCM g 235
API g 1
Ethanol g 5
PDMS g 329
Heptane g -

Assumptions :
• There are no losses during transfer
• 1 : Coecervate Phase (M1)
• 2 : Continuous Phase (M2 )
• The mass fraction of API in continuous phase is negligible to the fraction in
Coecervate phase ( >> )
• Total Mass Balance
+ +
585
585 - …………………………………(1)

• Mass Balance of API :

1 = ……………………(2)

• Mass Balance of PLGA :

• Mass Balance of DCM :

235 = ……………………(4)

• Mass Balance of Ethanol :

5 = ……………………(5)

• Mass Balance of PDMS :

329 = ……………………(6)
• Mass Balance of Continuous Phase :
+
1= +

• Mass Balance of Coecervate Phase :

1= +
Tests for Analytical Team

Unit Sample 1 Sample 2 Sample 3 Sample 4 Sample 5

Polymer g 15 15 15 15 15
DCM g 235 235 235 150 235
API g 1 1 1 1 1
Ethanol g 5 5 5 5 50
PDMS g 329 100 200 329 329
Heptane g