Professional Documents
Culture Documents
Content
Introduction
Classification
Properties
Advantage
Application
Introductio
n
Definition
• The compounds having high molecular masses and
formed by monomers are termed polymers.
• The term polymer is derived from the Greek words:
Poly means (many)
Meros means (unit) or (parts)
• Polymers are very large molecules made when
hundreds of monomers join together to from long
chains.
Polymerisation: The process by which the monomer molecules are linked to from a big
polymer molecule is called “polymerisation”
The first polymer-drug conjugates appeared around 1955, being mescaline -N-
vinylpyrolidine conjugate one of the first.
Herman Staudinger, who received the Nobel Prize in Chemistry in 1953, coined
the
term “macromolecule” in 1922 and used it in reference to polymers.
In 1994 , the first synthetic polymer-drug conjugate designed to treat cancer was clinically
tested.
Were placed in the market and five years later the first therapeutic nanoparticles(albumin-
entrapped paclitaxel) was approved as a treatment for metastatic breast cancer.
• Due to their distinctive nature, polymer are used in
pharmaceutical industries.
• Polymers are pharmaceutically used in tablets as binders, in
liquids suspensions and emulsions as flow controlling
agents, to cover the unpleasant taste of drug as film coating
agents, and also as stabilisers and protective agents
• Polymers are broadly used in day-to-day life
• Important advancements have been made in the
development of several drug delivery devices using
polymers
Classification of Polymer
3. Synthetic 3. Cross-linked
polymer polymers
Based on origin of source
• Natural polymers: These are derived from natural sources and can be
polysaccharides and protein in chemical nature.
For example: Albumin, Cellulose, Starch, Rubber,
Wool.
• Semi-synthetic polymers: These types of polymers are derived from
naturally occurring polymers by means of chemical modifications.
• Vulcanized rubber is used in making tyres as the process of vulcanization
increases the mechanical strength of natural rubber.
For e.g. Vulcanized rubber, Gun cotton, Cellulose diacetate, HPMC,
etc.
• Synthetic polymers: Synthetic polymers are of artificial origin
which consist of fibers.
• This is the polymer, which was prepared by Laboratory is known as
Synthetic Polymer
• For example: Buna-S, Buna-R, Nylon, Polythene, Polyester
Based on structure
• Linear polymers: The smallest repeating unit
arranged in straight line path is known as Linear
polymer.
For example: PVC
The carrier of polymer degrades into non-toxic and absorbable sub-units that get
metabolised lately.
The system is biocompatible, does not exhibit dose dumping at any time period, and the
polymer retains its properties until after drug depletion.
Biodegradable systems remove the need for surgical removal of implanted device after
drug depletion.