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  • Deksel 4 DR

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    This document describes a nano carrier technology called Deksel that entraps vitamin D molecules in a lipid nano carrier to improve absorption. The nano carrier has a stearic protective layer, pH resistant electrostatic layer, and hydrophilic layer to protect the vitamin D from enzymes and acids during digestion. The Deksel nanoparticles are less than 150nm in size, have over 95% entrapment of vitamin D, and a zeta potential of -28mV for stability. The small size and surface charge of Deksel nanoparticles allow for rapid absorption through the intestinal mucus layer and cell membranes via several pathways for enhanced oral bioavailability compared to free vitamin D.

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    Deksel 4 Dr (1)

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    This document describes a nano carrier technology called Deksel that entraps vitamin D molecules in a lipid nano carrier to improve absorption. The nano carrier has a stearic protective layer, pH resistant electrostatic layer, and hydrophilic layer to protect the vitamin D from enzymes and acids during digestion. The Deksel nanoparticles are less than 150nm in size, have over 95% entrapment of vitamin D, and a zeta potential of -28mV for stability. The small size and surface charge of Deksel nanoparticles allow for rapid absorption through the intestinal mucus layer and cell membranes via several pathways for enhanced oral bioavailability compared to free vitamin D.

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    9 views6 pages

    Deksel 4 DR

    Uploaded by

    meiyappan.r
    This document describes a nano carrier technology called Deksel that entraps vitamin D molecules in a lipid nano carrier to improve absorption. The nano carrier has a stearic protective layer, pH resistant electrostatic layer, and hydrophilic layer to protect the vitamin D from enzymes and acids during digestion. The Deksel nanoparticles are less than 150nm in size, have over 95% entrapment of vitamin D, and a zeta potential of -28mV for stability. The small size and surface charge of Deksel nanoparticles allow for rapid absorption through the intestinal mucus layer and cell membranes via several pathways for enhanced oral bioavailability compared to free vitamin D.

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    © All Rights Reserved
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    of 6

    AQUEOL Nano Technology

    Enzyme Protective
    Vitamin D Molecules
    Stearic Layer
    are entrapped in
    Protects from
    Lipid Nano Carrier
    Lipase Enzyme

    pH Resistant Hydrophilic layer


    Electrostatic Layer Helps easy passage
    protects from Gastric through unstirred
    Acid water layer

    Negative Zeta Potential


    prevents agglomeration
    and increases shelf life

    Functionalized Nano Carrier Technology


    Deksel Functionalized Nano Particle

    Deksel Nano Size < 150nm


    Particle D D
    D3 3 D3 3
    D D
    D3D3 3 D 3
    D 3 Zeta potential -28 mV
    D3 D3 3 D3
    D3
    D3 D D3
    3
    Entrapment of D3 >
    95%
    Improved Absorption of Deksel Nanoparticles
    • Deksel doesn't depend upon lipid digestion process for its absorption.
    • Deksel shows rapid gastric emptying thereby increasing rate of absorption
    • Deksel Nanoparticles are unaffected by varying GIT pH conditions (Stomach:1-3,
    Deodenum:4-5, Intestine: 6 - 6.8)
    • Deksel Nanoparticles absorption is unaffected by fed-fast variation hence predictable oral
    bioavailability.
    • Because of small size and surface charge Deksel Nano particles rapidly accumulate in mucus
    layer and from there enter unstirred water layer due to hydrophilic surface.
    • Deksel Nanoparticle as such are transported across enterocytic membrane via several
    mechanisms thereby enhancing the absorption.
    DEKSEL ABSORPTION PATHWAYS
    THROUGH INTESTINAL LUMEN (A des Rieux et al 2006)

    Stearically stabilized Digestion by Mixed Micelle Formation


    D3 Nanoparticles pancreatic lipase?

    < 150nm Bile salts + PL


    < 50nm

    Mucoadhesion Paracellular transport


    Transcellular Pathway Passive Diffusion

    Unstirred water layer

    M CELL

    A des Rieux et al , Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanist approach, J Cont.. Rel. 116 (2006) 1-27
    Advantages of DEKSEL
     Nano-entrapment of D3 in Deksel :
    • Improves stability of Vitamin D3.
    • Rapid absorption and enhanced oral bioavailability
    • Minimal fed-fast and inter-individual variations
    • Ensures absorption even in disorders in which lipid digestion is
    compromised (liver & pancreatic disorders)
     Nitrogen Purging Technology – prevents oxidation / degradation

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