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Preparation of Filled Hard Gelatin Capsules
Dry Powder
Milling
To achieve uniform drug distribution through out a powder
mix, it is advantageous that the density and particle size of
the drug and non-drug components are similar. This is
achieved
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Umar Farooq (milling). 7
Diluent
Generally, hard gelatin capsules are used to encapsulate
Glidant
The powder mixture or granules must be free-flowing to
properties.
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Wetting agent
Addition wetting agents, as sodium lauryl sulfate, in
This small tablet can be placed inside the capsule following the
addition of a small quantity of the powder and the filling
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completed.
Powders Granules Beads
1."Punch" Method
counterweight.
later use.
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Then the plates are adjusted again so that the capsule
bodies will "drop" into place so that the tops are flush
:Coni snap
Slightly tappered, attached with locking roofs
the capsules.
sieve where the "cleaning salt" will pass through the sieve.
Obtaining Obtaining
of gelatin solutions of gelatin solutions
with stage of without stage of
swelling swelling
HJ Series Gelatin Melting Tank
Obtaining of gelatin solutions
with stage of swelling
capsules.
portable.
formulation.
Preservatives
Preservatives are added to prevent mould growth in the
gelatin shell. Potassium sorbitate and methyl, ethyl and
propyl hydroxybenzoate (methyl-, ethyl- and
propylparaben) are common additives.
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Colours
A wide range of colours can be incorporated into soft
gelatin shells
Water-soluble dyes (synthetic and vegetable), insoluble
inorganic and organic pigments and lakes.
Opacifiers
Titanium dioxide is the most common. It is added in
concentrations of about 0.01-0.5%.
Enteric treatment
Enteric properties can be imparted to soft gelatin shells by
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coating with 4% cellulose Umar Farooq
acetate phthalate. 50
Formulation of the capsule contents
Water-immiscible oils:
Either volatile or non-volatile oils,
Fixed aromatic vegetable oils,
Aliphatic, aromatic and chlorinated hydrocarbons,
Liquid ethers and esters.
containers
capsules.