1.

2.



;
1.
2.
3.


;
1.
2.
3.
4.
5.

6.
7.

1+2+3
1+2+4

 (1)

(NFKb, AP-1)
Zykova SN Diabetes 2000



(Foss-Freitas MC, et al. Diabetes Res Clin Pract 2008; 82: 329
Geerlings SE, et al. Eur J Clin Invest 2000; 30: 995)
6000

IL -8, IL-6, NF ()

1000 pg/ml

1000

30 pg/ml

2000

1000 pg/ml

3000

1000 pg/ml LPS

4000

30 pg/ml LPS

TNF (pg/ml)

5000

 (2)

 (1)

IL-10 (
)
MCH I

Price CL J Cell Mol Med 2010

Ashwell JD et al Anu Rev Immunol 2000

 (2)

()

Cupps TR et al J Clin Invest 1985

Jabara HH et al J Immunol 1991



;
1.

2.
3.
4.
5.

6.
7.

8.

1+3+5
1+2+4


()

Staphylococcus aureus
MRSA

Graham PL Ann Inter Med 2006

Candida
albicans

()
Rhizopus spp (mucormycosis)
Hostetter MK Diabetes 1990
Ferguson BJ Otolaryngol Clin North Am 2000

TammHorsfall

Meiland R . Drugs 2002

75 , ,

/ Klebsiella
spp ,
.

, ,

.

1.

2.

3.

Diagnosis, Prevention, and Treatment of CatheterAssociated Urinary Tract Infection in Adults:

2009 International Clinical Practice Guidelines
from the Infectious Diseases Society of America
Thomas M. Hooton,1 Suzanne F. Bradley,3 Diana D. Cardenas,2 Richard
Colgan,4 Suzanne E. Geerlings,7
James C. Rice,5,a Sanjay Saint,3 Anthony J. Schaeffer,6 Paul A. Tambayh,8
Peter Tenke,9 and Lindsay E. Nicolle10,

Clinical Infectious Diseases 2010; 50:625663

105 cfu/ml
105 cfu/ml
( )
10 cfu/ml

CID IDSA Guidelines

>105 cfu/mL
()
>104 cfu /mL
()
()


(>100 cfu/ mL)
European Association of Urology Guidelines 2012



;
1.
2.
3.
4.

5.
6.

1+2
1+3



80%
50%
70%
>60

Huang JJ et al Arch Inter Med 2000

( )
, 80%
(
) 7-10%
(50%)

Grupper M et al Medicine (Baltimore) 2007


;
1.
2.
3.
4.

Class 1 ( )
Class 2 ( )
Class 3A ( )
Class 3B ( )
Class 4 ()

;
1.
2.
3.
4.
5.


(Gram - ,
, Enterococcus)

( )

Somani BK et al J Urol 2008

( )
Candida spp
Candida albicans, Candida glabrata, Candida
tropicalis

(fungus ball)
:

:
Sobel JD, Kaye D UTIs in Mandell, Douglas and Bennetts
Principles and Practice of Infectious Diseases 7th Edition