PHARMACEUTICAL CHEMISTRY I

1. General discussion on the following inorganic compounds including important physical and chemical properties, medicinal and pharmaceutical uses storage condition and chemical incompatibility Unit :- I (A). Acids, bases and buffers:- Boric acid, cal. hydroxide, HCL acid, strong ammonium hydroxide, sod. Hydroxide, official buffers. (B). Gastro intestinal agent :1. Acidifying agents :- Dil. HCL. 2. Antacids :- Sod. bicarbonate, Aluminum hydroxide gel, Aluminum phosphate, cal.carbonate, mag. Carbonate, mag. Trisilicate, mag. Oxide, combination of antacids preparation 3. Protective and adsorbents :- Bismuth sub carbonate and Kaolin 4. SalineCathertics :- Sod. Potasium tartarate and magnesium sulphate. . Unit :- II (C). Antioxidants :- Hypophosphorus acids, sulphur dioxide sodium bi sulphite, sodium meta bi sulphite, sodium thio sulphate, nitrogen and sodium nitrite. (D). Topical Agents:1. Protective :- Talc, zinc oxide, Calamine, Zinc stearate, titanium di oxide, silicone polymers. 2. Antimicrobials and astringents :- Hydrogen peroxide, pot. Permanganate, Chlorinated Lime, Iodine, Solution of iodine, Boric acid, borax, silver nitrate, mild silver protein, mercury, yellow mercuric oxide, ammoniated mercury. 3. Sulphur and its compounds :- Sublimed sulphur, PPTsulphur, selenium Sulphide 4. Astringents :- Alum and Zinc sulphate Unit :- III (E). Dental Products :- sodium fluoride, Stannous fluoride calcium carbonate,sodium meta phosphate, di calciumphosphate, strontium chloride, zinc chloride. (F).Inhalants:- O2, CO2, N2O. (G).Respiratory stimulants:- ammonium carbonate. (H).Expectorants and emetics:- NH4Cl, KI, antimony potassium tartrate. (I). Antidotes:- sodium nitrite 2. Major intra and extra cellular electrolytes:(A). electrolytes used for replacement therapy:- Nacl and its preparations, KCl and its preparations.

(B). physiological acid-base balance and electrolytes used :- sodium acetate, potassium acetate, sodium bi carbonate injection, sodium citrate , potassium citrate, sodium lactate injection and NH4Cl and its preparations. (C) combination of oral electrolyte powders and solutions. Unit :- IV 3. Inorganic official compounds of iron, iodide and calcium ; ferrous sulfate, calcium gluconate 4. Radio pharmaceuticals and contrast media-radio activity:- , , radiations , biological effects of radiations, measurement of radio activity, G.M counter; radio isotopes:- their uses, storage and precautions with special reference to the official preparation. Radio opaque contrast media- barium sulfate 5. Identification tests for cations and anions as per I.P. Unit :- V 6. Quality control of drugs and pharmaceuticals:- importance of Quality control, significant errors, methods used for Quality control, source of impurities in pharmaceuticals, limit tests for arsenic, chlorides, sulfates, iron and heavy metals.