Schematic Diagram

Precipitating


Environmental conditions (open spaces with water




Predisposing

pots, and plants)

Geographical area tropical islands in the Immunocompromise

Pacific (Philippines) and Asia Mosquito carrying dengue virus

Soldier



Sweaty skin




Aedes aegypti (dengue virus carrier):
8-12 days of viral replication on
mosquitos salivary glands
Bite from mosquito (Portal of Entry in
the Skin)
Allowing dengue virus to be inoculated
towards the circulation/blood
(Incubation Period: 3-14 days
Virus disseminated rapidly into the blood
and stimulates WBCs including B
lymphocytes that produces and secretes
immunoglobulins (antibodies), and
monocytes/macrophges, neutrophils








































Antibodies attach to the viral antigens,
and then monocytes/macrophages will
perform phagocytosis through Fc receptor
(FcR) within the cells and dengue virus
replicates in the cells

Entry to the
spleen
Entry to the
bone marrow

Recognition of dengue viral antigen on
infected monocyte
Release of cytokines which consist of vasoactive
agents such as interleukins, tumor necrosis factor,
urokinase and platelet activating factors which
stimulates WBCs and pyrogen release
Dengue







































Virus ultimately targets liver
and spleen parenchymal cells
where infection produces
apoptosis/cell death
Cellular direct destruction and
infection of red bone marrow
precursor cells as well as
immunological shortened platelet

Hepatosplenomegaly Thrombocytopenia
Dengue Hemorrhagic


Increase number and size of the pores in the
capillaries which leads to a leakage of
fluid from the blood to the interstitial fluid
(capillary leakage) of the different























Pleural effusion
Ascite
Complications:
Intense bleeding
Pulmonary Edema
Shock
Very low blood
pressure
Liver cirrhosis
Death
Recovery