Pathophysiology:

Age, Sex,

Leptospire

Geographic,
Season

from infected
animals

Direct invasion of tissue

on susceptible host;
induced endotoxins,hemolysin & lipase

capillary vasculitis

endothelial edema,
necrosis, lymphocytic infiltration

loss of RBC & fluid

via enlarged conjunction & fenestrae

CBC

x-ray

urinalysis

ECG

PT
Petechiae,

Jaundice,

Alveolar

Tubular

Cardiac

Hemorrhage,

intraparenchy

vascular

capillary

necrosis,

lesions,

focal

mal bleeding,

congestion &

injury (focal/

epicardial

necrosis,

bleeding along

disorganizati

diffuse),

interstitial
nephritis

&

infiltration

serosa &

on of liver
cell plates

interstitial &

endocardial

within the

intra-

petechiae,

alveolar

myocardial

adrenal
gland

edema &

interstitial

bleeding,

edema,

frank
hemorrhage

coronary
arteritis

mucosa;
thrombocytope
nia