Scribd Logo
Upload

Welcome to Scribd!

  • Intravena: Lestiariani AMRAN NUR S.Farm., Apt 15020120365

    Uploaded by

    Lesty Ariani
    8 views4 pages

    Original Title

    LESTI HADIS IV.docx

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    8 views4 pages

    Intravena: Lestiariani AMRAN NUR S.Farm., Apt 15020120365

    Uploaded by

    Lesty Ariani

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 4

    INTRAVENA

    Parameter Intravena
    1.
    2.
    3.
    4.

    Tetapan eliminasi
    Waktu paruh
    Volume distribusi
    AUC (Area under curve)
    Contoh :
    T (jam)

    Cp

    Log Cp

    0,5

    5,94

    0,773

    1,0

    5,30

    0,724

    1,5

    4,72

    0,673

    2,0

    4,21

    0,624

    3,0

    3,34

    0,523

    4,0

    2,66

    0,424

    6,0

    1,68

    0,225

    8,0

    1,06

    0,025

    10,0

    0,67

    -0,173

    12,0
    0,42
    -0,376
    Ket : Untuk intravena penentuan orde reaksi semua data
    diregresikan
    Orde 0
    a = 5,275
    b = -0,474
    r = -0,952
    Orde 1
    a = 0,823
    b = -0,999
    r = -0,999
    Termasuk Orde 1 karena nilai r = -0,999 mendekati -1
    1. Tetapan eliminasi (k)
    k = -b x 2,3
    = - (-0,099) x 2,3
    = 0,227 jam-1
    2. Waktu paruh (t)
    0,693
    t =
    k
    t =

    0,693
    0,227

    = 3,052 jam
    LESTIARIANI
    AMRAN NUR S.Farm., Apt
    15020120365

    INTRAVENA
    3. Volume distribusi (Vd)
    Vd =

    F x Do
    Cp 0

    1 x 10000
    anti log a

    10000
    anti log 0,823

    10000
    6,652

    = 1503,307 mL
    4. AUC (Area Under Curve)
    Cp n+Cp n1
    tn
    x(t n t n1 )
    a. [ AUC ]tn1 =
    2

    [ AUC ]1,0
    0,5
    =

    5,30+5,94
    x (1,00,5)
    2

    5,30+5,94
    x 0,5
    2

    = 2,81 g jam/mL

    [ AUC ] 1,5
    1,0
    =
    =

    4,72+5,30
    x (1,51,0 )
    2

    4,72+5,30
    x 0,5
    2

    = 2,505 g jam/mL
    4,21+4,72
    x (2,01,5)
    [ AUC ]
    =
    2
    2,0
    1,5

    4,21+4,72
    x 0,5
    2

    = 2,232 g jam/mL
    LESTIARIANI
    AMRAN NUR S.Farm., Apt
    15020120365

    INTRAVENA

    3,0

    [ AUC ]2,0
    =

    1,06+ 1,68
    x 2,0
    2

    = 2,74 g jam/mL
    0,67+1,06
    x (10,08,0)
    [ AUC ]
    =
    2
    10,0
    8,0

    1,68+ 2,66
    x 2,0
    2

    = 4,34 g jam/mL
    1,06+ 1,68
    x (8,06,0)
    [ AUC ]8,0
    6,0
    =
    2
    =

    2,66 +3,34
    x 1,0
    2

    = 3 g jam/mL
    1,68+ 2,66
    x (6,04,0)
    [ AUC ]6,0
    4,0
    =
    2
    =

    3,34 +4,21
    x 1,0
    2

    = 3,775 g jam/mL
    2,66 +3,34
    x ( 4,03,0)
    [ AUC ]4,0
    3,0
    =
    2
    =

    3,34 +4,21
    x (3,02,0)
    2

    0,67+1,06
    x 2,0
    2

    = 1,73 g jam/mL
    0,42+ 0,67
    x (12,010,0)
    [ AUC ]12,0
    10,0
    =
    2
    =

    0,42+ 0,67
    x 2,0
    2

    = 1,09 g jam/mL
    [AUC] = 2,81 + 2,505 + 2,232 + 3,775 + 3 + 4,34 +2,74 + 1,73 +

    b.

    1,09
    = 24,222 g jam/mL
    Cpn
    t
    [ AUC ]tn =
    k

    LESTIARIANI
    AMRAN NUR S.Farm., Apt
    15020120365

    INTRAVENA
    =

    c.

    0,42
    0,227

    = 1,850 g/mL
    F x Do
    [ AUC ] t = k x Vd
    =

    1 x 10000
    0,227 x 1503,307

    10000
    341,250

    = 29,304 g jam/mL
    [ AUC ]ttn
    x 100
    d. % [AUC] ekstrapolasi =
    AUC
    =

    1,850
    x 100
    24,222

    = 7,637 %

    LESTIARIANI
    AMRAN NUR S.Farm., Apt
    15020120365

    You might also like