DRUG

CLASSIFIC ATION

INDICATIO N

ACTION AND PHARMACOKINE TICS Action: Anti-inflammatory, analgesic and antipyretic activities related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known. Pharmacokinetics: Route: Oral Onset: Varies Peak: 2-3 hours Duration: 6hours

CONTRAINDICATI ON

ADVERSE EFFECT

Drug name: Mefenamic Acid Dosage: 250mg, 1tablet Twice a day

NSAID

-Relief of moderate pain when therapy will not exceed 1week. -Treatment of primary dysmenorrhea

-Contraindicated with hypersensitivity to mefenamic acid, aspirin allergy, and as treatment of perioperative pain with coronary artery bypass -Use cautiously with asthma, renal or hepatic impairment, peptic disease, GI bleeding, hypertension, heart failure, pregnancy, lactation

-CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, tinnitus, ophthalmic effect -Dermatologic: Rash, pruritus, sweating, dry mucous membrane, stomatitis -GI: Nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence -GU: Dysuria, renal impairment -Hematologic: Bleeding, platelet inhibition with higher doses, neutropenia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, granulocytopenia, aplastic anemmia, decreasedHgb or Gct, bone marro depression, menorrhagia -Respiratory: Dyspnea, hemoptysis, pharyngitis, bronchospasm, rhinitis -Other: Peripheral edema, anaphylactoid reaction to anaphylactic shock