Drawing

Generic Name Magnesium Oxide

Brand Name Trimag
Classification Clinical: Antacid, anticonvulsant, electrolyte, laxative
Systemic (dietary supplement replacement): Found primarily in
intracellular fluids.
Therapeutic Effect: Essential for enzyme activity, nerve
conduction, muscle contraction. Maintains and restores
Action magnesium levels.

Anticonvulsant: Blocks neuromuscular transmission, amount of

acetylcholine released at motor end plate.
Therapeutic Effect: Produces seizure control.
Dosage 500mg TID PO
Indication Magnesium replacement
Contraindication Systemic: Heart block, myocardial damage, renal failure.
Occasional
Systemic (dietary supplement, electrolyte replacement): Reduced
Side Effects
respiratory rate, decreased reflexes, flushing, hypotension,
decreased heart rate.
Systemic use may produce prolonged PR interval, widening of
QRS interval. Magnesium toxicity may cause loss of deep tendon
Adverse Effects reflexes, heart block, respiratory paralysis, cardiac arrest.
Antidote: 1020 ml 10% calcium gluconate (510 mEq of
calcium).
Drug
May decrease absorption of quinolones, tetracycline,
Drug Interaction bisphosphonates. May increase effects of antihypertensives.
Lab values
Systemic: None significant.
1. Assess if patient is sensitive to magnesium.
2. Assess renal function, serum magnesium.