I FA S

S T U D Y M AT E R I A L

M O D E L PA P E R I
PARTAandB

CSIRNETLIFESCIENCES

DEC2010

INSTITUTEFORADVANCEDSTUDIES
B7SARASWATINAGAR,JODHPUR(RAJ.)
02912721056
email:ifasnet@gmail.com

 MODELPAPERICSIRNETLIFESCIENCES:DEC2010

12. For hydrogen atom nth states energy level is

1.Thederivativeof
is
proportionalto
1. 2. 1.1/n2 2.1/n

3.n 4.n2
3.tan2 4.0
13.Whichisfaster,RAMorROM
12.Theproductofrootsof5x2+28x+15=0is 1.RAMisfaster
1.3 2.15 2.ROMisfaster
3.15 4.5 3.Bothhavethesamespeed
4.Bothofthemareveryslow
3.Theperiodictableisbasedon
1.Thenumberofelectron 14. ABC is a triangle of sides 15, 20 and 25. Let P, Q
2.Thenumberofnucleons and R be the mid points of the sides. Then the
3.Coreelectronicconfigurations perimeterofPQRis.
4.Valanceelectronicconfigurations 1.10 2.15
3.20 4.30
4. A group of 425 people are registered serially
startingfrom1086.Ifwemakepairsofoneevenand 15. Which of the following is not an input output
one odd numbered candidates based on their device?
registrationnumbers 1.CDROM 2.Harddisc
1.Atleast3peoplewillbeleftout 3.Floppydrive 4.DATdrive
2.Atoddnumberedpersonwillbeleftout
3.Anevennumberedpersonwillbeleftout 16. What is the major difference between a 386 PC
4.Noneofthemwillbeleftout and286PC.
1. 386 PC has a Math CoProcessor built in, 286 PC
5. If the mass of an object on the moon is 60 Kg, its doesnot
massontheearthwillbe 2.286PCneedsonly286cyclestocompleteitsworks
1.60Kg 2.Morethan60Kg whilea386PCrequiresa386scycles
3.Lessthan60Kg 4.93Kg 3.386 PCis32bitprocessor,whilea286isa16bit
processor
6.Thethirdlargestconstituentofouratmosphereis 4.386PCisbiggerinsizethana286PC
1.Watervapors 2.Argon
3.Carbonmonoxide 4.Methane 17.Thedeepesttrenchesintheoceansarefound
1.Nexttomidoceanridges
7. Moons surface shows far more craters than the 2.AlongTransformfaults
earthssurfacebecause 3.behindpassiveplatemargins
1.ofanopticalillusion 4.alongsubductionzones
2.Moonwasbombardedmoreheavily
3.ofdifferentvolcanicmechanisms 18. The clock speed of Intel Pentium Chip is
4.ofabsenceofweatheringanderosiononthemoon approximately
1.10Hz 2.103Hz
8.Whenwewalkonaslopewetendtobend 3.106Hz 4.109Hz
1.Toraiseourcentreofgravity
2.Tolowerourcentreofgravity 19.Whichofthefollowingisanoperatingsystem
3.Toreducethefrictionalforce 1.UNIX 2.LOTUS
4.Toincreaseourfrictionalforce 3.FORTRAN 4.PASCAL

9.Theworkdonebyaradialforceof10Nactingona 20.Onacementfloor,theportionbeneathapatchof
particle of mass 2 Kg moving in a circular orbit of water appears darker than the dry part of the floor
radius1meteris becauselightundergoes.
1.10joule 2.20joule 1.Totalinternalreflection 2.Interference
3.5joule 4.Zero 3.Diffraction 4.Polarization

10.Whenaparticleofchargeqisatrest,itsproduces 21. A stone dropped vertically from the top of a hill
1.Onlyelectricfield takes10secondstohittheground.Ifthesamestone
2.Onlymagneticfield is thrown out horizontally from the top of the hill
3.Bothelectricandmagneticfield withaspeedof25m/sec,thetimeittakestohitthe
4. A magnetic field depending upon the sign of the groundwillbe.
charge 1.98sec 2.49sec
3.25sec 4.10sec
11.Apersonstandingonthetopofahillfiresagun.
Theechooftheguncomesbackfromanearbyhillin 22. A brick shaped metal block has sides of length 2
3 seconds. What is the distance between the hills cm,3cmand4cmrespectively.Theblockis heated.
(Velocityofsoundinairis340m/s) Due to thermal expansion, each edge increases in
1.1020m 2.510m lengthby1%.Thepercentageincreaseinthevolume
3.205m 4.430m ofthemetalblock
1.1% 2.3%
3.9% 4.24%

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23. On addition of a tablespoon of common salt to velocities are imparted to the blocks. The maximum
glassofwater,theelectricalconductancewill extensionofthespringwillbe:
1.Decreases 2.Increases
3.Remainconstant 4.Becomezero

24. To convert a galvanometer as a voltmeter we

connect which one of the following to the
galvanometer? (1)30cm (2)25cm
(1)Alowresistanceinseries (3)20cm (4)15cm
(2)Ahighresistanceinseries
(3)Ahighresistanceinparallel 35.Consider the followingprogramme andwritethe
(4)Alowresistanceinparallel resultthatwillprintatendofprogram
A=4
25. For a reaction to occur spontaneously at a given B=5
temperatureandpressure DoWhileA0
(1)H>0andS<0 (2)S<O If AB
(3)S>O (4)H<TS A=AB
Else
26.Thecoloursproducedwhenwhitelightisincident B=BA
onthethinfilmofasoapbubblearedueto EndIf
(1)scatteringoflight (2)interferenceoflight PRINTA,B
(3)dispersionoflight (4)refractionoflight
(1)0,0 (2)0,1
27. About howmuchofthenetprimaryproductivity (3)1,1 (4)1,0
of an aquatic ecosystem is eaten and digested by
herbivores? 36.FromanelevatedpointAofabuildingastoneis
(1)1% (2)10% projectedverticallyupwards.Whenthestonereaches
(3)40% (4)90% adistancehbelowA,itsVelocityisdoubleofwhatit
wasaheighthaboveA.Maximumheightachievedby
28. Thepartofamushroomthatis visibleabove the stoneaboveAis:
groundisa (1)3/5h (2)5/6h
(1)basidiocarp (2)zygospore (3)6/5h (4)5/3h
(3)ascarp (4)ascogonium
37. Two blocks of masses 2 kg and 1 kg
29.WhichofthefollowingcanadduptoNeconomy respectively are tied to the ends of a
ofsoils? string which passes over a light
(1)Aulosira (2)Oscillatoria frictionlesspulley.Themassesareheldat
(3)Spirulina (4)Spirogyra restatthesamehorizontallevelandthen
released. The distance traversed by
30. Which of the following processes releases a centre of mass in 2 seconds is: (g = 10
carbondioxidemolecule? m/s2)
(1)Glycolysis (1)1.42m (2)2.22m
(2)Lacticacidfermentation (3)3.12m (4)3.33m
(3)Alcoholfermentation
(4)Hydrolysisofglycogen 38. Antivirus, in computer terminology
means
31.Rootlikeandleaflikestructuresofamoss,andthe (1)Drugthatinhibitviralreplication
rootsandleavesofavascular,plantare (2)Drugthatkillsvirus
(1)analogousstructures (3)Organismthatfeedoncomputervirus
(2)homologousstructures (4)HighlevelProgramwhichcrackviralcodes
(3)embryonicstructures
(4)vestigialstructures 39. A cheetah can sprint with a maximum speed of
120km/h,buthastostopafterevery20seconds.The
32. The microspore of a conifer, on release from the maximumspeedofagazellecanachieveis75km/h,
sporangiumdividesbymitosistoproducea butitcanmaintainitforseveralminutes.Whatisthe
(1)multicellularembryo (2)femalegametophyte maximum distance between the cheetah and gazelle
(3)pollengrain (4)needle at which the cheetah could still catch the gazelle by
sprintingatthemaximumspeed?
33.Inspermatogenesis,theacrosomeofthespermis (1)250meters (2)175meters
formedby (3)240meters (4)225meters
(1)mitochondria (2)nucleus
(3)Golgicomplex (4)lysosome 40. Two solutions A and 8 differ in pH by 4 units.
Theirhydrogenionconcentrationdiffersby
34.Twoblocksofmass3kgand6kgrespectivelyare (1)4 (2)40000
placed on a smooth horizontal surface. They are (3)4000 (4)10,000
connectedbyalightspringofforceconstantk=200
N/m.Initiallythespringisunstretched.Theindicated

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41. How many different types of gametes could be
produced by an individual with the arbitrary
genotypeofAAbbCCDdEe?
(1)Two (2)Four
(3)Six (4)Eight
42.Duringcytokinesisinananimalcell,aconstricting
ring pinches the dividing cell into the two daughter
cells.Thiscontractileringisformedbywhichofthe
followingstructures?
(1)Centrioles (2)Microtubules
(3)Microfilaments (4)Thespindleapparatus
43. An Xlinked recessive gene produces redgreen
color blindness in humans. A woman with normal
color vision whose father was colorblind marries a
colorblindman.Whatistheprobabilitythattheirson
willbecolorblind?
(1)0 (2)1/4
(3) (4)3/4
44.WhichofthefollowingisNOTacorrectstatement
abouttheprocessofmeiosis?
(1) Meiosis I separates chromosomes; meiosis II
separateschromatids.
(2)SynapsisandcrossingoveroccurduringmeiosisI.
(3) Kinetochores are responsible for aligning
chromatidsduringmeiosisI.
(4)Karyokinesisoccursbeforecytokinesis.
45.Endoplasmicreticulum(ER)isthesiteofallofthe
followingEXCEPT
(1) drug detoxification by means of mixedfunction
oxidases
(2) synthesis of proteins that are secreted from the
cell
(3) Nlinked glycosylation of newly formed
polypeptides
(4)hydrolyticactivitiescarriedbyacidhydrolases
46.Exonsofagenearedefinedas
(1) the untranslated regions of the corresponding
mRNA
(2) regions in the corresponding mRNA that are
involvedininitiationoftranscription
(3) regions that are not transcribed by RNA
polymerase
(4) regionsthatremain inthecorrespondingmRNA
aftersplicing
47. In Drosophila, regions of polytene chromosomes
showpuffsatdifferenttimesindevelopment.Studies
with labeled compounds have indicated that the
localizationtothepuffsoftritiated
(1)thymidineindicatesthatRNAisbeingsynthesized
(2) leucine indicates that new proteins are being
synthesized
(3)uridineindicatesthatDNAisbeingsynthesized
(4)uridineindicatesthatRNAisbeingsynthesized
48. In Drosophila, a homeotic mutation would be the
mostlikelyexplanationforwhichofthefollowing?
(1)Adecreaseinthenumberofparasegments
(2) A leg developing where an antenna would
normallybelocated
(3)Forkedanddensebodybristlesinsteadofstraight
andsparseones
(4)Asignificantlyshorterlifespan
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49. Humoral immunity is characterized by all of the
followingEXCEPT
(1)amemoryresponse
(2)antigenantibodyinteraction
(3)thesynthesisofimmunoglobulins
(4)theproductionofcytotoxicTcells
50. In adult mammals, the primary site for the final
stageofdifferentiationofTlymphocytesisthe
(1)bonemarrow (2)bursaofFabricius
(3)thymus (4)liver
51.IntheDNAsequence5CGATCGGCT3,whichof
the following is considered a transition type
mutation?
(1)5CGACCGGCT3 (2)5CGATGGCT3
(3)5CGATCGCCT3 (4)5CGAUCGGCU3
52.Thereceptivesurfaceforpollenonanangiosperm
floweristhe
(1)anther (2)ovary
(2)style (4)stigma
53.Immediatelyafterfertilizationinanimals,thefirst
structuralandbiochemicalchangesintheeggare
initiatedby
(1)newgenetranscription
(2)thereleaseofCa2+frominternalreservoirs
(3)theinitiationofDNAsynthesis
(4)aloweringofcytosolicpH
54. It is possible for a cell to make proteins that last
for months; hemoglobin in red blood cells is a good
example. However, many proteins are not this long
lasting.Theymaybedegradedindaysorevenhours.
Whydocellsmakeproteinswithsuchshortlifetimes
ifitispossibletomakethemlastlonger?
(1)Mostproteinsareusedonlyonce.
(2)Mostcellsinthebodyliveonlyafewdays.
(3) Cells lack the raw materials to make most of the
proteinstheyneed.
(4)Thisenablescellstocontroltheamountofprotein
present.
55.Whichofthefollowingistrueofhomeoticgenes?
(1)thehomeodomainfunctionsinbindingtoDNA
(2)theyserveasanexampleofgenomicgenecontrol
(3) all homeotic genes contain a promoter called a
homeobox
(4)alloftheabovearecorrect
56. Dioxin, produced as a byproduct of various
industrialchemicalprocesses,issuspectedofcausing
cancer and birth defects in animals and humans. It
apparently acts by entering cells and binding to
proteins,alteringthepatternofgeneexpression.The
proteinsaffectedbydioxinareprobably
(1)watersolubleproteins. (2)DNApolymerase.
(3)transcriptionfactors. (4)enhancers.
57.QTLanalysisisusedto:
(1)identifyRNApolymerasebindingsites
(2)mapgenesinbacterialviruses
(3) determine which genes are expressed at a
developmentalstage
(4) identify chromosome regions associated with a
complextraitinageneticcross
 MODELPAPERICSIRNETLIFESCIENCES:DEC2010

58. When dominant epistasis is operative between 67.Microbialfermentationinthegutofacow

twogeneloci,theclassical9:3:3:1ratiobecomes (1) produces fatty acids as a major nutrient for the
modifiedinto cow.
(1)9:3:4ratio (2)9:6:4ratio (2) occurs in specialized regions of the small
(3)12:3:1ratio (4)15:1ratio intestine.
(3) occurs in the cecum, from which food is
59. Phytochromes are bluish chromoproteins. The regurgitated, chewed again, and swallowed into the
phytochromechromophoresarecalledas truestomach.
(1)Phycobillins (2)Caretenoids (4)producesmethaneasamajornutrient.
(3)Xanthophylls (4)Porphyrins
68. Which of the following is stimulated by
60. What are the sexual phenotypes of the following cholecystokinin?
genotypesinDrosophilaXXY,XO? (1)Stomachmotility
(1)Male,female (2)Male,male (2)Releaseofbile
(3)Intersex,female (4)Female,male (3)Secretionofhydrochloricacid
(4)Secretionofbicarbonateions
61. The most likely explanation for the observation
that humans from entirely different societies smile 69.ThenucleotidesequenceofaDNAcodonisACT.A
whentheygreetafriendisthat messenger RNA molecule with a complementary
(1)theyshareacommonculture. codonistranscribedfromtheDNA.Intheprocessof
(2) they have imprinted on smiling faces when they protein synthesis, a transfer RNA pairs with the
wereinfants. mRNAcodon.Whatisthenucleotidesequenceofthe
(3)theyhavelearnedthatsmilingdoesnotstimulate tRNAanticodon?
aggression. (1)TGA (2)UGA
(4)smilingisaninheritedbehaviorpattern. (3)TGU (4)ACU

62.Tobeabletopilot,ananimalmust 70.Whichofthefollowingarearrangedinthecorrect
(1)haveatimecompensatedsolarcompass. orderbysize,fromlargesttosmallest?
(2)orienttoafixedpointinthenightsky. (1)chromosomegenecodonnucleotide
(3)knowthedistancebetweentwopoints. (2)nucleotidechromosomegenecodon
(4)knowlandmarks. (3)codonchromosomegenenucleotide
(4)genechromosomecodonnucleotide
63. Which ofthe following is true about the building
ofawebbyaspider? 71.Oneoftheparentsofacrosshasamutationinits
(1) Spiders use a different design depending on the mitochondria. In that cross, that parent is taken as a
environment. male. During segregation of F2 progenies that
(2) A young spider learns to build a web by copying mutationisfoundin
thewebofitsmother. (1)onethirdoftheprogenies
(3)Ayoungspiderimprintsonitsmothersweb,and (2)noneoftheprogenies
whenitissexuallymature,itreplicatesthatdesign. (3)alltheprogenies
(4) The motor patterns for web building are largely (4)fiftypercentoftheprogenies
inherited.
72. When a freshwater protozoan possessing a
64.Thedigestiveenzymesofthesmallintestine contractile vacuole, is placed in a glass containing
(1)donotfunctionbestatalowpH. marinewater,thevacuolewill
(2) are produced and released in response to (1)Increaseinnumber (2)Disappear
circulatingsecretin. (3)Increaseinsize (4)Decreaseinsize
(3) are produced and released under neuronal
control. 73.Oneofthefollowingisaveryuniquefeatureofthe
(4)areallsecretedbythepancreas. mammalianbody:
(1)Homeothermy
65.Whichstatementaboutnutrientabsorptionbythe (2)Presenceofdiaphragm
intestinalmucosalcellsistrue? (3)Fourchamberedheart
(1)Carbohydratesareabsorbedasdisaccharides. (4)Ribcage
(2) Fats are absorbed as fatty acids and
monoglycerides. 74.Chemicallyhormonesare
(3) Amino acids move across the plasma membrane (1)Biogenicaminesonly
onlybydiffusion. (2)Proteins,steroidsandbiogenicamines
(4)Biletransportsfatsacrosstheplasmamembrane. (3)Proteinsonly
(4)Steroidsonly
66.Chylomicronsarelikethetinymicellesofdietary
fatinthelumenofthesmallintestineinthatboth 75. Which one of the following pairs is not correctly
(1)arecoatedwithbile. matched?
(2)arelipidsoluble. (1)VitaminB12Perniciousanaemia
(3)travelthroughthelymphaticsystem. (2)VitaminB6Lossofappetite
(4)arecoatedwithlipoproteins. (3)VitaminB1Beriberi
(4)VitaminB2Pellagra

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76. Duodenum has characteristic Brunners glands (1)Testtubecontainingcalciumbicarbonate

whichsecretetwohormonescalled (2)Chilledtesttube
(1)Kinase,estrogen (3)Testtubecontainingheparin
(2)Secretin,cholecystokinin (4)Testtubecontainingsodiumoxalate
(3)Prolactin,parathormone
(4)Estradiol,progesterone 87.Whatisakeystonespecies?
(1)Aspecieswhichmakesuponlyasmallproportion
77.Mastcellsofconnectivetissuecontain of the total biomass of a community, yet has a huge
(1)Vasopressinandrelaxin impactonthecommunitysorganisationandsurvival
(2)Heparinandhistamine (2)Acommonspeciesthathasplentyofbiomass,yet
(3)Heparinandcalcitonin has a fairly low impact on the communitys
(4)Serotoninandmelanin organization
(3) A rare species that has minimal impact on the
78.Cancercellsaremoreeasilydamagedbyradiation biomassandonotherspeciesinthecommunity
thannormalcellsbecausetheyare (4) A dominant species that constitutes a large
(1)starvedofmutation proportion of the biomass and which affects many
(2)undergoingrapiddivision otherspecies
(3)differentinstructure
(4)nondividing 88.DNAfingerprintingrefersto
(1)MolecularanalysisofprofilesofDNAsamples
79. ATPaseenzymeneeded for musclecontraction is (2)AnalysisofDNAsamplesusingimprintingdevices
locatedin (3) Techniques used for molecular analysis of
(1)Actinin (2)Troponin differentspecimensofDNA
(3)Myosin (4)Actin (4)Techniquesusedforidentification offingerprints
ofindividuals
80. Which one of the following pairs is not correctly
matched? 89.Flagellaofprokaryoticandeukaryoticcellsdiffer
(1)StreptomycesAntibiotic in
(2)SerratiaDrugaddiction (1)Typeofmovementandplacementincell
(3)SpirulinaSinglecellprotein (2)Locationincellandmodeoffunctioning
(4)RhizobiumBiofertilizer (3)Microtubularorganizationandtypeofmovement
(4)Microtubularorganizationandfunction
81. A free living nitrogenfixing cyanobacterium
which can also form symbiotic association with the 90. The animals with bilateral symmetry in young
waterfernAzollais stage,andradialpentameroussymmetryintheadult
(1)Tolypothrix (2)Chlorella stage,belongtothephylum
(3)Nostoc (4)Anabaena (1)Annelida (2)Mollusca
(3)Cnidaria (4)Echinodermata
82. In the ABO system of blood groups, if both
antigensarepresentbutnoantibody,thebloodgroup 91.WhichofthefollowingisLEASTlikelytocausea
oftheindividualwouldbe protooncogenetobecomeanoncogene?
(1)B (2)O (1)Ageneisincorporatedintoaretroviralgenome.
(3)AB (4)A (2) A gene is moved close to an enhancer, causing
excessproducttobemade.
83. Which one of the following pairs correctly (3) A gene is truncated, yielding a protein with
matches ahormonewitha disease resulting fromits modifiedactivity.
deficiency? (4) A gene is moved into centromeric
(1)LuteinizinghormoneFailureofovulation heterochromatin,silencingitstranscription.
(2)InsulinDiabetesinsipidus
(3)ThyroxineTetany 92. The physiological role of restriction
(4)ParathyroidhormoneDiabetesmellitus endonucleasesisto
(1) allow the in vitro construction of recombinant
84. In a mutational event, when adenine is replaced DNAmolecules
byguanine,itisacaseof (2)methylatehostDNA
(1)Frameshiftmutation (2)Transcription (3)removeRNAprimerduringDNAsynthesis
(3)Transition (4)Transversion (4)cleaveforeignDNAmoleculesthatenterthecell

85. Which of the following hormones is not a 93. During the evolution of life on Earth, the
secretionproductofhumanplacenta? photosynthetic organisms initially responsible for
(1)Humanchorionicgonadotropin raising atmospheric oxygen concentrationsfrom less
(2)Prolactin than1percenttoabout20percentwere
(3)Estrogen (4)Progesterone (1)cyanobacteria (2)archaea
(3)diatoms (4)floweringplants
86.Youarerequiredtodrawbloodfromapatientand
to keep it in a test tube for analysis of blood 94.PlantspeciesAhasadiploidnumberof12,while
corpuscles and plasma. You are also provided with species B has a diploid number of 16. Which of the
thefollowingfourtypesoftesttubes.Whichofthem following would be the diploid number of an
willyounotuseforthepurpose?

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 MODELPAPERICSIRNETLIFESCIENCES:DEC2010
allotetraploid derived from a hybrid between these
twospecies?
(1)14 (2)28
(3)40 (4)44
95. If two parents that are heterozygous (Aa) at a
singlelocusgiverisetooffspringthatare25percent
AA,50 percent Aa,and 25percent aa,thenallof the
followingaretrueEXCEPT:
(1)Theparentsarediploidorganisms.
(2)Theaalleleisrecessivelethal.
(3)Theallelesassortindependently.
(4)Thegametescombineatrandom.
96. The mating system in which a female defends a
large, multipurpose territory within which several
males defend smaller, exclusive territories is known
as
(1)polygynandry
(2)resourcedefensepolygyny
(3)resourcedefensepolyandry
(4)haremdefensepolygyny
97. One theory of the evolution of cooperation in
animals statesthat under conditions of low resource
availability, some members of a population are
willing to sacrifice their own efforts to reproduce to
ensurethatthepopulationasawholewillnotexhaust
all its resources and go extinct. Which level of
selectionisdescribedinthismodel?
(1)Directionalselection (2)Individualselection
(3)Disruptiveselection (4)Groupselection
98. Charles Darwin discussed all of the following
EXCEPT:
(1) Natural selection tends to remove those
organisms that are poorly adapted to their
environments.
(2) Individuals in a population compete with one
anotherforlimitedresources.
(3) Gene mutations are the source of variation for
evolution.
(4) Organisms tend to produce more offspring than
cansurviveineachgeneration.
99. When numbers of organisms and amounts of
living material in successively higher trophic levels
are compared, the values usually take the form of a
pyramid, with the largest numbers and greatest
biomass in the producer trophic level. However, in
somemarineecosystems,theconsumertrophiclevels
contain significantly greater amounts of living
material than does the primaryproducer trophic
level. The best explanation for this is which of the
following?
(1) The main primary producers in marine
ecosystems are microscopic algae with extremely
highratesofpopulationturnover.
(2) Most consumers in marine ecosystems are filter
feeders that must maintain large basket like
structuresforextractingfoodfromthewater.
(3) The increased availability of solar radiation in
marine ecosystems means that fewer primary
producers are required to support marine food
chains.
(4) Marine zooplankton often produce large
extensions of their bodies in order to increase
buoyancy.
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100.Thefitnessofagenotypeishigherwhenitisrare
inapopulationthanwhenitiscommon.Whichofthe
followingtypesofselectionismostlikelyoperating?
(1)Densityindependentselection
(2)Frequencydependentselection
(3)Directionalselection
(4)Stabilizingselection
101. Which of the following represents the most
reducedformofcarbon?
(1)RCH3 (2)RCOOH
(3)RCHO (4)RCH2OH
102.TheKm(Michaelisconstant)ofanenzymefora
substrateisdefinedoperationallyas
(1) half the substrate concentration at which the
reactionrateismaximal
(2)thesubstrateconcentrationatwhichthereaction
rateishalfmaximal
(3)thedissociationconstantoftheenzymesubstrate
complex
(4) the dissociation constant of the enzyme product
complex
103. The reversible reaction in which
dihydroxyacetone phosphate and glyceraldehyde 3
phosphate combine to form fructose 1,6
bisphosphateisbestcharacterizedas
(1)analdolcondensation (2)aGrignardreaction
(3)afreeradicalreaction (4)ahydrolyticreaction
104. Dinitrophenol (DNP) uncouples mitochondrial
electrontransportfromoxidativephosphorylationby
(1)dissipatingtheprotongradient
(2)inhibitingcytochromeoxidase
(3) dissociating the F0 and F1 units of the ATP
synthasecomplex
(4)bindingirreversiblytoubiquinone
105. Most of the dry mass in the trunk of a tree was
originallyderivedfrom
(1)thesoil (2)lightenergy
(3)aminoacids (4)CO2
106. Which of the following cell compartments is
associated with a protein skeleton composed of
lamins?
(1)Chloroplast (2)Basementmembrane
(3)Mitochondrion (4)Nucleus
107. Initiation of mitogenesis by epidermal growth
factor and depolarization of the membrane of a
skeletal muscle cell by acetylcholine are similar in
thateach
(1) involves, as an essential early step, an ion flux
across the plasmamembrane receptor of the
respondingcell
(2) requires a ligandmediated conformational
change in a plasmamembrane receptor of the
respondingcell
(3) requires activation of a G protein on the
cytoplasmic face of the plasma membrane in the
respondingcell
(4) is mediated by phosphorylation of the ligand
receptorintherespondingcell
 MODELPAPERICSIRNETLIFESCIENCES:DEC2010
108. The principal site of peptide neurohormone
biosynthesisisthe
(1)nucleus
(2)roughendoplasmicreticulum
(3)dendrite (4)synapticvesicle
109. A previously unknown organism that lacks a
nuclear membrane and mitochondria has just been
discovered. Which of the following would this
organismmostlikelypossess?
(1)Lysosomes (2)Cilia
(3)Ribosomes
(4)Endoplasmicreticulum
110. Drugs that either stabilize or depolymerize
microtubules can be used in cancer chemotherapy.
Which of the following is correct concerning such
drugs?
(1)Theystimulatetheimmunesystem.
(2)Theypreventchromatincondensation.
(3)Theypreventmovementoftumorcellsintoother
tissues.
(4)Theyinterferewithmitosis.
111. If the genetic code consisted of four bases per
codon rather than three, the maximum number of
uniqueaminoacidsthatcouldbeencodedwouldbe
(1)16 (2)64
(3)128 (4)256
112.Inhumans,theBarrbodyisan
(1)activeXchromosomeinfemales
(2)activeXchromosomeinmales
(3)inactiveYchromosomeinmales
(4)inactiveXchromosomeinfemales
113. Which of the following types of molecules is
alwaysfoundinvirions?
(1)Lipid (2)Protein
(3)DNA (4)RNA
114. An RNAdependent RNA polymerase is likely to
bepresentinthevirionofa
(1)DNAvirusthatmultipliesinthecytoplasm
(2)DNAvirusthatmultipliesinthenucleus
(3)minusstrandRNAvirus
(4)plusstrandRNAvirus
115.InE.coli,theinabilityofthelacrepressortobind
aninducerwouldresultin
(1)nosubstantialsynthesisofgalactosidase
(2)constitutivesynthesisofgalactosidase
(3)induciblesynthesisofgalactosidase
(4) synthesis of galactosidase only in the absence
oflactose
116.Ifsucroseandmonosodiumglutamate(MSG)are
addedtoavinegarandoilsaladdressingandshaken,
the mixture will eventually separate into two phases
of different density and polarity. Where will most of
the sucrose and the MSG be located following phase
separation?
(1)Bothwillconcentrateinthevinegar.
(2)Bothwillconcentrateintheoil.
(3)Bothwillconcentrateattheinterface.
(4) Sucrose will concentrate in the oil and MSG will
concentrateinthevinegar.
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117. A major advantage of monoclonal antibodies
comparedtopolyclonalantibodiesisthatmonoclonal
antibodies
(1) have identical binding sites that recognize a
specificepitope
(2)crosslinkmoleculesthatshareantigenicsites
(3) are more easily coupled with probes such as
fluorescentdyes
(4) can be produced against proteins that are
immunogenicinrabbits
118.TheinitialproductofphotosyntheticCO2fixation
inC3plantsis
(1)glyceraldehyde3phosphate
(2)dihydroxyacetonephosphate
(3)3phosphoglycerate
(4)phosphoenolpyruvate
119.Inwhichofthefollowingsystemsistheentropy
thegreatest?
(1)Watervapor
(2)LiquidwateratpH7.0,37C
(3)Waterwithsufficientacid addedtolowerthepH
to(2)0
(4)Supercooledwater(liquidwateratatemperature
lessthan0C)
120.Whichenzymeisactivatedbyphosphorylation?
(1)AcetylCoAcarboxylase
(2)Fructose1,6bisphosphatase
(3)Glycogensynthase
(4)Fructose2,6bisphosphatase
121.Allofthefollowingstatementsaboutmonomeric
GproteinsaretrueEXCEPT:
(1) They are regulated by GTPGDP exchange
proteins.
(2)TheyareregulatedbyGTPaseactivatingproteins.
(3)TheyregulateenzymesthatsynthesizecGMP.
(4)Theyregulatevesiclefusion.
122. All of the following are known to be part of a
signaltransductioncascadeEXCEPT
(1)phosphorylationoffibronectin
(2) dissociation of the components of a
heterotrimericGprotein
(3) enzymatic breakdown of phosphatidyl inositol
bisphosphate(PIP2)
(4)elevationofintracellular[Ca2+]
(5)activationofcGMPphosphodiesterase
123. Which of the following will result if the level of
potassium ions in a solution bathing a nerve cell is
raisedtenfoldwhilethecellisatitsrestingstate?
(1)ThedecreaseinthenormalK+gradientwillcause
partialdepolarization.
(2) The amplification of the normal K+ gradient will
causepartialhyperpolarization.
(3)TheaddedextracellularK+willaccelerateNa+/K+
pumpingandcausepartialdepolarization.
(4)TheaddedextracellularK+willcauseligandgated
ionchannelstoopen.
124. SNARE proteins are found in the membranes of
allofthefollowingcompartmentsEXCEPT
(1)Mitochondria (2)Golgicomplex
(3)Earlyendosome
(4)Endoplasmicreticulum
 MODELPAPERICSIRNETLIFESCIENCES:DEC2010

125. Treatment of root tip meristem cells with the (3)protonationoftheactivesitehistidineresidueby

microtubule inhibitor colchicine results in all of the
followingEXCEPT
(1)inductionofpolyploidy
(2)preventionofcytokinesis
(3)inhibitionofmitoticspindleassembly
(4)cessationofDNAreplication
126. Genes a, b, and c are widely spaced in the
bacterial genome. Transducing phage from an a+ b+
c+bacteriumwereusedtoinfectacultureofabc (3)Electronmicroscopy
cells, and b+ transductants were selected. Which of
thefollowing best describesthe predictedgenotypes
ofthesetransductants?
(1)Mostlyab+c (2)Mostlyab+c+
(3)Mostlya+b+c+
(4)a+b+c+andab+cinequalfrequencies
127. If a cell has one chromosome in excess of the
normal number of chromosomes present in the
nucleus,itisreferredtoas
(1)aneuploid (2)polyploid
(3)tetraploid (4)haploid
128. Which of the following statements about
retrotransposonsiscorrect?
(1)TheytransposeviaanRNAintermediate.
(2)Theycontaingenesforribosomalproteins.
(3) They possess a gene for RNAdependent RNA
polymerase.
(4) They possess genes that encode proteins that
integrateRNAintochromosomes.
129. When bacteria produce mammalian proteins,
cDNAisusedratherthangenomicDNA.Whichofthe
followingisthebestexplanation?
(1) It is easier to clone cDNA than genomic DNA of
comparablesize.
(2)ItiseasiertocloneRNAthanDNA.
(3)Itisnotpossibletoclonetheentirecodingregion
ofthegene.
(4)Mosteukaryoticgeneshaveintronsthatcannotbe
removedinbacteria.
130. A mutation deleting an upstream activating
sequenceforasinglegenewouldbeexpectedtobe
(1)polar (2)transdominant
(3)cisdominant (4)silent
131.Thedifferencebetweenthemolecularweightof
sucroseandthatofthesumofthemolecularweights
ofitscomponents(glucoseandfructose)is
(1)0 (2)16
(3)18 (4)180
132. Proline disrupts helical structure in proteins
becauseitis
(1)anacidicaminoacid(2)aaromaticaminoacid (3) Addition of oligosaccharides to all three types of
(3)animinoacid (4)abasicaminoacid
133. Glycogen phosphorylase exists in two forms in
skeletal muscle. The active form, phosphorylase a, is
generatedfromphosphorylasebby
(1) reversible dimerization of phosphorylase b,
triggeredbycalciumion
(2)proteolyticcleavageofadecapeptidefromtheN
terminusofphosphorylaseb
adecreaseinintracellularpH
(4) ATPdependent phosphorylation of a specific
serineresidueoneachsubunit
134. An alphahelical conformation of a globular
proteininsolutionisbestdeterminedbywhichofthe
following?
(1)Ultravioletvisibleabsorbancespectroscopy
(2)Fluorescencespectroscopy
(4)Circulardichroism
135.Thenucleosideadenosineexistsinaprotonated
form with a pKa of 3.8. The percentage of the
protonatedformatpH4.8isclosestto
(1)1 (2)9
(3)50 (4)91
136. Membrane carrier proteins differ from
membranechannelproteinsbywhichofthefollowing
characteristics?
(1) Carrier proteins are glycoproteins, while channel
proteinsarelipoproteins.
(2) Carrier proteins transport molecules down their
electrochemical gradient, while channel proteins
transport molecules against their electrochemical
gradient.
(3) Carrier proteins can mediate active transport,
whilechannelproteinscannot.
(4) Carrier proteins do not bind to the material
transported,whilechannelproteinsdo.
137. Particular RNAs that are important for
development are located in distinct regions of the
Drosophila embryo. This is most directly
demonstratedbyusing
(1)westernblotting (2)northernblotting
(3)insituhybridization (4)invitrotranslation
138. Which of the following events can induce a
transient arrest in the translation of a secretory
protein?
(1)BindingofapolysometoanERreceptor
(2)BindingofSRPtoanNterminalsignalsequence
(3)BindingofsnRNPstothelargeribosomalsubunit
(4) Presence of a stoptransfer sequence in the
polypeptide
139. The common pathway of entry into the
endoplasmic reticulum (ER) of secretory, lysosomal,
and plasma membrane proteins is best explained by
whichofthefollowing?
(1) Binding of their mRNAs to a special class of
ribosomesattachedtotheER
(2)Additionofacommonsortingsignaltoeachtype
ofproteinaftercompletionofsynthesis
proteins
(4) Presence of a signal sequence that targets each
typeofproteintotheERduringsynthesis
140. Eukaryotic cells with DNA damage often cease
progressionthroughthecellcycleuntilthedamageis
repaired. This type of control over the cell cycle is
referredtoas
(1)proteosomecontrol (2)damagecontrol
(3)checkpointcontrol (4)anticyclincontrol

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