Barbiturates Hemin, Glucose hydroxymethylbilane

synthase aka
+ - LEAD PBG-DEAMINASE

Glycine + Succinyl-CoA
ALA-S 5-ALA ALA-D Porphobilinogen
(B6) Acute intermittent Acute Intermittent
Congintal Sideroblastic Anemia. porphyria
Porphyria:
ALA-S mutation -autosomal dominant

Rate limiting -paranoia

-abdominal pain
-port-wine urine

LEAD

FERROCHELATASE
Protoporphyrin IX HEME B
Fe 2+ 2H +

Acquired Sideroblastic Anemia.

Pb-Poisoning
Coproporphyrinogen III UPG III-DECARBOXYLASE Uroporphyrinogen III
UPG III-SYNTHASE
Hydroxymethylbilane
Porphyria cutanea tarda
-most common
-autos. dominant
-photosens. (blister, hyprpigm.)
- red- brown urine
-exacerbated by alcohol