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  • Craniopharyngioma: Intracranial Pressure

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    Gabriela Grace Sinaga
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    This document discusses craniopharyngioma, a type of brain tumor. It first notes that remnants of the craniopharyngeal duct can be found in the suprasellar region. It then explains that mutations in the CTNNB1 gene, which encodes beta-catenin, can lead to abnormal accumulation of beta-catenin and overactivation of the Wnt signaling pathway. This dysregulation of transcription can result in cell hyperplasia and the formation of craniopharyngioma. Symptoms include necrosis and cyst formation that increase intracranial pressure, as well as calcium deposition that can cause blurred vision or multiple pituitary hormone deficiencies.

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    This document discusses craniopharyngioma, a type of brain tumor. It first notes that remnants of the craniopharyngeal duct can be found in the suprasellar region. It then explains that mutations in the CTNNB1 gene, which encodes beta-catenin, can lead to abnormal accumulation of beta-catenin and overactivation of the Wnt signaling pathway. This dysregulation of transcription can result in cell hyperplasia and the formation of craniopharyngioma. Symptoms include necrosis and cyst formation that increase intracranial pressure, as well as calcium deposition that can cause blurred vision or multiple pituitary hormone deficiencies.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    11 views1 page

    Craniopharyngioma: Intracranial Pressure

    Uploaded by

    Gabriela Grace Sinaga
    This document discusses craniopharyngioma, a type of brain tumor. It first notes that remnants of the craniopharyngeal duct can be found in the suprasellar region. It then explains that mutations in the CTNNB1 gene, which encodes beta-catenin, can lead to abnormal accumulation of beta-catenin and overactivation of the Wnt signaling pathway. This dysregulation of transcription can result in cell hyperplasia and the formation of craniopharyngioma. Symptoms include necrosis and cyst formation that increase intracranial pressure, as well as calcium deposition that can cause blurred vision or multiple pituitary hormone deficiencies.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    Remnants of Craniopharyngeal Duct occuying

    suprasellar region

    Mutation in CTNNB1 that encode Beta-Catenin

    Abnormal cytoplastic and nuclear


    accumulation of Beta-Catenin

    Overactivation of Wnt signalling pathway

    Abnormal transcription of DNA

    Cell hyperplasia

    Craniopharyngioma

    Necrotic of debris in cyst ⬆ ️ Intracranial Pressure

    ⬆ ️ Calcium deposition Optic Chiasma Anterior Pituitay

    Calcification
    Blurred Vision Multiple Pituitary Hormone Deficiency (MPHD)

    GH ⬇ ️ GnRH ⬇ ️

    FSH ⬇ ️ LH ⬇ ️
    Protein synthesis⬇ ️ IGF1⬇ ️ Decreased fat utilization

    Abdominal fat accumulation Spermatogenesis ⬇ ️ Testosterone ⬇ ️


    Keratin protein cell⬇ ️ ⬇ ️ Chondrocytic cells

    Trunkal obesiy Testicular Volume ⬇ ️ Low Secondary Sexual


    Poor nail growth ⬇ ️ Bone formation Weight ⬆ ️
    Characteristic

    Short stature Delayed Bone age Axillary hair ❎ Small Phallus Pubic Hair ❎

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