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DISORDER FSH/LH ESTROGEN WITHDRAWAL

BLEEDING
Hypothalamic-pituitary
X
Ovarian
X
End-organ defect

Constitutional defect

AMENORRHOEA

Breakdown of premenstrual epitelium

Excessive amount of PG and bradykinin

Excessive PG

Reduced
Incrased uterine contraction uterine blood Myometrial ischaemia
flow, esp
during intense
uterine
contraction

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