Food Grade Products SODIUM HYALURONATE

Product Name Molecular Weight Applications

200 kDa ~ 600 kDa

HAPLEX® Sodium Hyaluronate
Customized molecular weight for your application

Used as ingredient
200 kDa ~ 600 kDa
HAPLEX®Plus Sodium Hyaluronate in food or health food
1,000 kDa ~1,500 kDa

GabarelaxTM Gamma Aminobutyric Acid --

Pharmaceutical Grade Products

Product Name Product Code Intrinsic Viscosity m³/kg Applications

HA-EP2 Measured Value

For parenteral preparations, including
Injection Grade intra-articular and intra-ocular
HA-EP1.8 preparations, such as OVD，
(DMF & CEP & KDMF) 1.6~2.2
Sodium Hyaluronate intra-articular injections, intradermal
injections for aesthetic correction,
HA-EP3.0 anti-adhesive products, etc.
2.7~3.6
(DMF & CEP & KDMF)
Hyatrue TM

HA-EP1 Measured Value For parenteral preparations or oral

preparations not including intra-articular
Medical Grade HA-E2.0 (DMF) 1.2~2.8 and intra-ocular preparations.
It can be used in eye drops,
Sodium Hyaluronate HA-E3.0 (DMF) 2.7~3.6 contact lens solutions, topical
preparations for wound or burn healing,
HA-P-0.5 (DMF) 0.5~1.0 medical lubricants, etc.

Global Distribution
Subsidiary Company in USA
Bloomage Freda Biopharm USA Inc.
181 New Road, Suite 308, Parsippany NJ 07054
TEL: +1-862-485-8343
FAX: +1-973-428-4925

Bloomage Freda Biopharm Japan

R. 521 Banchoheim, 1-2 Nibancho, Chiyoda-ku,
Tokyo 102-0084
TEL: +81-3-6256-9688
FAX: +81-3-6256-9687

Shanghai Office
TEL: +86-21-64480654
FAX: +86-21-64480654

Guangzhou Office Add : No.678 Tianchen St., High - Tech Development Zone,Jinan,China 250101
TEL: +86-20-36261514 Tel：+86 531 82685998 Fax：+86 531 82685988
FAX: +86-20-86253859 www.bloomagefreda.com
E-mail:customer@bloomagefreda.com
Copyright C Jun. 2018, Bloomage Freda Biopharm
Bloomage Freda Biopharm Co.,Ltd. was established in 1998 by Bloomage International Investment Group Inc.
and it’s national high-tech enterprises.For the past 20 years, the company has focused its efforts on Product List
R&D,production and sales of Sodium Hyaluronate (HA)， and has become one of the world's leading Certification Cosmetic Grade Products
manufacturers. The applications and specifications of HA vary by product and are divided into Pharmaceutical,
Cosmetic, and Food grades. 1 HA
Product Name Molecular Weight Benefits Applications

High Molecular Weight

HA-THM Sodium Hyaluronate ≥1,800kDa
Skin care products:
HA-T Sodium Hyaluronate 1,000kDa ~ 1,800kDa cream, emulsion, essence,
Pharmaceutical Grade Sodium Hyaluronate 应用
lotion, gel, facial mask, etc.
Low Molecular Weight
HA-TLM 10kDa ~ 1,000kDa

COMPANY
Sodium Hyaluronate Moisturizing Makeup products:
Low Molecular Weight Lubricity and film-forming effects lipstick, eye shadow,
HA-TLM 200kDa ~ 400kDa Increase emulsion stability
HybloomTM Sodium Hyaluronate foundation, etc.

HISTORY
20-40 Nutrition delivery
Hydrolyzed Hyaluronic Acid Prevent and repair skin damage Cleansing products:
HA-TLM 3-5 37 kDa~56 kDa
Anti-aging
facial cleaner, body wash, etc.
HA-Oligo Oligo Hyaluronic Acid ＜10kDa
Hair care products:
Sodium Hyaluronate
-- shampoo, hair conditioner,
HA-TL 1% Solution
styling gel, hair restorer, etc.
Low Molecular Weight Sodium --
HA-TLLM Hyaluronate 1% Solution
1990s Chief Scientist Dr. Guo Xueping initiated the research 2012 Successfully passed the on-site inspection by US FDA Transdermal absorption Recommended usage:
on producing HA by bio-fermentation technology Company name changed into Bloomage Freda Biopharm Co., Ltd. Deep moisturizing 0.1%-0.5%
miniHATM HA-Oligo Degraded by Hyaluronidase ＜10kDa Repair damaged cells
Subsidiary company Bloomage Freda Biopharm USA Inc. was Scavenge free radicals
1998 The company Shandong Freda Biochem Co., Ltd. was established in New Jersey Anti-aging
established and launched the production of Cosmetic
Grade HA by fermentation China GMP DMF CEP
2013 Achieved the National approval license for Injection Grade HA
2 HA Derivatives
used as an API
2001 Bloomage International Investment Group invested in Obtained the KDMF registration certificate for Injection Grade HA
the company HyacolorTM(Oil-dispersed HA) was successfully launched Product Name Benefits Applications Recommended Usage
The company passsed ISO 9001 Quality Management Obtained the 2013 China Personal Care & Cosmetics
System Certification Excellent protective film with long-lasting
Innovation Award for miniHATM moisturizing effect
HyacrossTM Skin care products 1%-5%
Hyaluronic Acid Elastomer Smooth and not sticky feeling
2002 Dr. Guo received Wu Jieping Medical Research Award
2014 New anti-wrinkle ingredient Gabacare BL98T(Aminobutyric
TM Increase skin elasticity and reduces roughness
& Paul Janssen Pharmaceutical Research Award for Acid) was successfully launched High affinity & adsorption
his great contributions to the HA industry HymagicTM-AcHA Superb moisturization
Obtained the 2014 China Personal Care & Cosmetics Cosmetic Grade Food Grade Skin care products 0.01%-0.1%
Production line of HA for Pharmaceutical Excipient Sodium Acetylated Hyaluronate Repair skin barrier
Innovation Award for HyacolorTM Improve skin elasticity
use passed the inspection by China FDA Sodium Hyaluronate & Aminobutyric Acid Sodium Hyaluronate & Gamma Aminobutyric Acid
New factory was put into operation
Obtained the Japan MF registration certificate for Medical Accurately targeting different skin layers, skin care＆hair care product
HymagicTM-4D 1%~10%
2004 Achieved the National approval license for Eye Drop
Grade HA
synergistic moisturizing
Grade HA used as a Pharmaceutical Excipient
High content of HA
HyacolorTM Specially for lip care products &
2005 The company moved into the new location in the 2015 New food ingredient GabarelaxTM was successfully launched
Oil-dispersed Sodium Hyaluronate
Unique HA microsphere technology
Perfect transdermal absorption make-up products 0.1%-2%
development zone of Jinan City New cosmetic ingredients HyacrossTM(Hyaluronic Acid
Excellent lip-plumping, repairing, moisturizing
Elastomer) & cationHATM(Substantive Sodium Hyaluronate)
were successfully launched High substantivity
2008 HAPLEX was approved as a New Dietary Ingredient
cationHATM Reduce the irritation caused by SAA
in China Obtained the 2015 China Personal Care & Cosmetics Specially for rinse-off products 0.5%-1%
Substantive Sodium Hyaluronate Improve the barrier function of the skin & scalp
Became the first holder of the production license for Innovation Award for GabacareTMBL98T and cationHATM Good compatibility
HA as a New Dietary Supplement in China
2016 New cosmetic ingredients HyafactorTM-NAG(Acetyl
2009 Injection Grade HA new workshop was established Glucosamine) & HyafactorTM-PGA(Sodium Polyglutamate) 3 Other Fermentation Products
and trial production was successful were successfully launched
Obtained the Russian registration certificate for Product Name Benefits Applications Recommended Usage
2010 Company name changed into Shandong Freda Pharmaceutical Grade HA
Biopharm Co., Ltd. Obtained the CEP registration certificate for Medical Grade HA COSMOS ECOCERT HALAL KOSHER
Reduce wrinkles and smooth skin
GabacareTM BL98T Skin care & Hair care products
HAPLEX® Plus with clinical efficacy data was successfully Repair the damaged skin 0.05%-0.3%
Aminobutyric Acid Promote the synthesis of HA and collagen Make-up products
2011 Achieved the National approval license for Eye Drop launched
Grade HA used as an API Bloomage Freda Biopharm Japan was established in Tokyo Promote HA synthesis and scavenge free radicals
HyafactorTM-NAG Natural exfoliating regulator Skin care products
Obtained the China GMP certificate 0.5%-2%
Acetyl Glucosamine Whiten and moisturize effects
Obtained the CEP and DMF certification for Injection 2017 Obtained the COSMOS certification for Cosmetic Grade HA
Grade HA and GabacareTM BL98T Promote the accumulation of NMFs
HyafactorTM-PGA Reduce the degradation of HA
miniHATM - the world first Oligo HA by enzymatic HymagicTM(Sodium Acetylated Hyaluronate ) was successfully Enhance moisturizing capacity and elasticity of skin Skin care products 0.05%-1%
degradation was successfully launched Sodium Polyglutamate
launched Inhibition of melanin production

Repairing skin barrier

Bioyouth™-Brice 0.5%-4%
Anti-oxidant and delaying skin aging Skin care ＆ rinse-off product
Brown Rice Ferment Filtrate Significant whitening