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Lectures 1-9 Cell Biology
Geoff McFadden, Rm 211 Botany
gim@unimelb.edu.au
8344 4272
Textbook
Required for both:
BIOL10002 &
BIOL10003
3. Prokaryotes
Lecture 1 - Introduction to Biology
1. Why study biomedical biology?
Human genome 2002
Cloning animals,
plants, humans - stem
cells
Is there life on mars?
Genetically Modified Organisms (GMO’s)
Who owns genes?
H1N1 flu
Should Indonesia get a royalty
from the vaccine?
Bioweapons
1st FOUNDATION OF BIOLOGY
Haeckel 1874
Webbing between fingers
degenerates by programmed cell
death to free digits
Homology - derived from a common ancestral feature
Biogeography also supports evolution - Unique
Australian flora & fauna due to protracted
evolution on isolated continent
Darwin’s three observations
• Individuals in a population vary → fitness
• Pass on traits (fitness) to offspring → heredity
• Never enough resources → competition for survival & reproduction
EVOLUTION IS A TWO STEP PROCESS
1. VARIABILITY
2. Ordering that variability by
NATURAL SELECTION
2nd FOUNDATION OF BIOLOGY
MJ Schleiden T. Schwann
Robert Hooke - invented first microscopes. Observed cells in cork but did not
recognise them as cells
Evolution is the fixation
Pauling & Zuckerkandl of
recognised
mutations
that DNAby natural
contains selection
the history of
evolution
Human & gorilla DNA >99%
identical
Studying the evolution
(relatedness) of all life
• All organisms have genes (DNA)
• DNA contains a history of evolution
• Compare genes to define relationships
Study of cell morphology gave a
paradigm where we recognised
to main types of cells
Prokaryotes vs Eukaryotes
(no nucleus) (with nucleus)
Three Domains of life
• Until recently we recognised two main
types of living things: prokaryotes &
eukaryotes
• DNA data revealed two very
different groups of prokaryotes
• Carl Woese called these domains
(Bacteria, Archaea, Eukarya)
• Archaea are related to us
THE MAJOR GROUPS OF ORGANISMS