10/1/2020 Test: Particle size reduction 1 | Quizlet

NAME

7 Matching questions

1. What are the effects of particle size for flowability

0
INCORRECT
A. basic properties
No answer given (content unifromity, flow and mixing and dissolution rate)
THE ANSWER

G. Smaller particles with high surface B. soft, weak

area do not flow as well as larger hard brittle
particles. The greater the surface area, hard, strong
the more dominant are surface soft, tough
interactions (friction, hard, tough
cohesion/adhesion...) that interfere
with flow C. crushing, disintegration, dispersion, grinding
Irregular shapes do not flow as well as and pulverization have been used
very smooth shapes (soft particles) synonymously with comminution depending
on the product, the equipment and the
2. what are primary properties of powder properties (4) process
INCORRECT

No answer given D. Dusting powders

THE ANSWER
(external, antifungal), for nappy rash for instance
Oral powders/granules
A. basic properties
or sachets (lemsip and infant pain relief powder)
(content unifromity, flow and mixing and dissolution rate)
• Powders for reconstitution
3. What are the other ways similar to comminution (antibiotics, injectables) ( add water first)
• Inhalation products (DPI or MDI) (contain solid particles)
INCORRECT
• Bulk powders for tablet and
No answer given
capsule processing
THE ANSWER

C. crushing, disintegration, dispersion, grinding E. Unit of particle size used most frequently
and pulverization have been used is μm, and equal to 10-6 m, 10-4 cm or 10-3
synonymously with comminution depending mm
on the product, the equipment and the
process F. Material properties: Why some materials are
readily prone to size reduction than others?
• Brittle
• Plastic
• Surface hardness
• Melting point
• Glass transition temperature (he temperature region where
the polymer transitions from a hard, glassy material to a soft,
rubbery material)

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4. What are examples of powders used in the pharmaceutical G. Smaller particles with high surface
industry (5) area do not flow as well as larger
particles. The greater the surface area,
INCORRECT
the more dominant are surface
No answer given
interactions (friction,
THE ANSWER
cohesion/adhesion...) that interfere
D. Dusting powders
with flow
(external, antifungal), for nappy rash for instance
Irregular shapes do not flow as well as
Oral powders/granules
very smooth shapes (soft particles)
or sachets (lemsip and infant pain relief powder)
• Powders for reconstitution
(antibiotics, injectables) ( add water first)
• Inhalation products (DPI or MDI) (contain solid particles)
• Bulk powders for tablet and
capsule processing

5. What are the material property factors (5)

INCORRECT

No answer given
THE ANSWER

F. Material properties: Why some materials are

readily prone to size reduction than others?
• Brittle
• Plastic
• Surface hardness
• Melting point
• Glass transition temperature (he temperature region where the
polymer transitions from a hard, glassy material to a soft,
rubbery material)

6. What is the most used unit of particle size

INCORRECT

No answer given
THE ANSWER

E. Unit of particle size used most frequently

is μm, and equal to 10-6 m, 10-4 cm or 10-3
mm

7. What are the differtent compositions of materails

INCORRECT

No answer given
THE ANSWER

B. soft, weak
hard brittle
hard, strong
soft, tough
hard, tough

7 Multiple choice questions

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10/1/2020 Test: Particle size reduction 1 | Quizlet

1. powder technology

A. What is plastic deformation

B. What will happen under very high force

C. What is another term for particle size reduction

D. What is the origin of the word commiution

2. The study of particle dimensions is of central

importance in many areas of technology.
Virtually all of the solid materials which are in common
use are at some point in a powder or granular form.

A. What are the material property factors (5)

B. What is the importance of particle size

C. What in particle size relates to suspensions

D. What is the effect of the large insoluble particles in suspensions?

3. Good flowability is essential to ensuring

uniform feeding of formulations to highspeed
tablet machines and capsule filling
machines
determines uniformity of tablet and
capsule weights (and uniformity of
doses, assuming uniform mixing of drug
and excipients had been achieved)

(Smaller particles with high surface

area do not flow as well as larger
particles. The greater the surface area,
the more dominant are surface
interactions (friction,
cohesion/adhesion...) that interfere
with flow
Irregular shapes do not flow as well as
very smooth shapes (soft particles)

A. What in particle size relates to suspensions

B. How do reduction of particle size help uniformity

C. How is particle size important in high speed tableting

D. What partilce size are used in the inhalation route

4. surface area

A. Explain elasticity

B. Dissolution rate

C. particle table

D. What will happen under very high force

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5. Pharmaceuticals (drugs & excipients)

Foods (grain, flour, sugar) (are granules)
Materials technology (ceramics, abrasives) (fine partcile shiny ceramcs, thick rough)
Building materials (sand and cement). (cerment fine strong, but larger not as strong)

A. What are examples of particle size (4)

B. What in particle size relates to suspensions

C. What are examples of powders used in the pharmaceutical industry (5)

D. What does particle size reduction involve (3)

6. uniformity in tablets and capsules

A. What does particle size influence

B. What is elastic deformation

C. What does particle size reduction involve (3)

D. What is plastic deformation

7. Powders are a part of every formulation process and most of finished products

A. What are the differtent compositions of materails

B. How can you particle size reduction improve dissolution

C. Why are powders important in the pharmaceutical industry

D. what are primary properties of powder properties (4)

6 True/False questions

1. Colloidal dispersions particles are too

small to be seen in the ordinary
microscope → How are Colloidal dispersions seen

INCORRECT

False
THE ANSWER

True

2. physical stability and

bioavailability
(small particle better as will dissolve and bigger will not dissolve, less dose to the drug than liquid so toxic effect)
]
(small particles pateint can get more drug

better dissoltion in stomach → What in particle size relates to suspensions

INCORRECT

False
THE ANSWER

True

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3. Sedimentation rate is proportional

to the particle size → What is Stokes' law

INCORRECT

False
THE ANSWER

True

4. Pharmaceutical significance of particle size

Pharmaceutical significance of particle shape
Principles and methods of size reduction → What does particle size reduction involve (3)

INCORRECT

False
THE ANSWER

True

5. permanent deformation → What is elastic deformation

INCORRECT

True
THE ANSWER

False
It should be → What is plastic deformation

6. higher number of particle = lower %CV

(means increase particle lower CV)

(Lower CV means better uniformity) → What is the origin of the word commiution

INCORRECT

True
THE ANSWER

False
It should be → How does the number of particle impact CV%

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