PSDB 12th Annual Convention

1st Speaker
2nd speaker

• Promiscuity of function
o Not necessarily exclusive
▪ Immune-suppressive
▪ Memory cells

• Regulatory B cells (Bregs)

o No specific marker
3rd Speaker

• Mimic hormone action by binding to hormone

receptors
• Block hormone receptors
• Binding with plasma proteins
• Affect rate of metabolism
 • Aquatic ecosystems are known to be the most
vulnerable in endocrine disruptions
o Fish are most commonly used as
models for endocrine disruption

• Yolk protein becomes deposited in unlikely

organs (e.g. kidneys)

Bisphenol A and E2 → focus on the seven lakes in San

Pablo
Methodology

• Estradiol was also tested in the fish

• Estradiol levels were also tested here

• DTA and E2 analysis

• Levels of caged carp were significantly higher
compared to the reference group
• Feral also had significantly higher levels in east
bay

• Indications that these fish have been exposed to

endocrine disruptors
• Pandin fish is the reference fish because it is the
best caught(?)
o Had significantly lower plasma VTG
vitellogeny ata
• More immature testes were created
o No presence of spermatozoa
o Composed of spermatogonia in
comparison to the other samples gotten
from other lakes

• Lakes are still being threatened by waste and

aquaculture

• E2 levels, in comparison to the reference site

(water from the deep well of UPLB something
station)

• Lowest value was obtained in Yambo