GoChi Notes

Immuno-Allergy Part VII Mild proteinuria, Hemoglobinuria, microscopic

Lecturer: Dra. Eva Dizon hematuria
Skin lesions reveal deposits of levels of IgA,
IgG, and IgE
Anaphylaxis
Treatment
serious allergic reaction that is rapid on onset
Dea Histamine
Under-diagnosed Steroids
sudden release of potent biologically active
mediators from mast cells and basophils Prevention

Cutaneous Seek alternative therapies

Urticaria, Angioedema, Flushing Non-equine derived formulations that may be
Respiratory in limited supply
Bronchospasm, Laryngeal edema For patients who have anaphylactic sensitivity
to horse serum
Cardiovascular A risk to benefit to assessment must be made
Myocardial ischemia, Dysrthymias, to determine the need to proceed with
Hypotension treatment
Gastrointestinal If needed, the serum can usually be
Nausea, Vomiting, Colicky, successfully administered by the process of
Abdominal Pain, Diarrhea rapid desensitization

Causes in Children

Food
Vaccination
Latex
Drugs

Penicillin
Cephalosporin
Vancomycin
NSAIDs

Serum Sickness

Hypersensitivity reactions (immune-complex

mediated)
Vaccine, Black widow bites, Venom
7-12 days to 3 weeks
Edema , erythema in the site of injection
Fever, Malaise, Rashes, Myalgia
GN, GBS, Carditis

Diagnosis

Circulating immune complexes are usually

detectable,with peak levels at 10-12 days
Serum complement Level (C3 and C4) -
decreased
ESR - elevated By: KTRC
Thrombocytopenia Special thanks to: TripleMed

GoChi Notes Page 1