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  • Potassium-Sparing Diuretics: Drug Name Clinical Use Phacmacodynamics Toxicity Mineralocorticoid Receptor Antagonist

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    Potassium-sparing diuretics work by reducing sodium absorption in the collecting tubules and ducts of the kidney, thereby reducing loss of potassium in the urine. The two main types are mineralocorticoid receptor antagonists like spironolactone and eplerenone, which bind to receptors to blunt aldosterone activity, and ENAC channel blockers like amiloride and triamterene, which directly interfere with sodium entry through epithelial sodium channels. Toxicities can include hyperkalemia, hyperchloremic metabolic acidosis, and kidney stones.

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    POTASSIUM

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    Potassium-sparing diuretics work by reducing sodium absorption in the collecting tubules and ducts of the kidney, thereby reducing loss of potassium in the urine. The two main types are mineralocorticoid receptor antagonists like spironolactone and eplerenone, which bind to receptors to blunt aldosterone activity, and ENAC channel blockers like amiloride and triamterene, which directly interfere with sodium entry through epithelial sodium channels. Toxicities can include hyperkalemia, hyperchloremic metabolic acidosis, and kidney stones.

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    Potassium-Sparing Diuretics: Drug Name Clinical Use Phacmacodynamics Toxicity Mineralocorticoid Receptor Antagonist

    Uploaded by

    SalomeSibashvili
    Potassium-sparing diuretics work by reducing sodium absorption in the collecting tubules and ducts of the kidney, thereby reducing loss of potassium in the urine. The two main types are mineralocorticoid receptor antagonists like spironolactone and eplerenone, which bind to receptors to blunt aldosterone activity, and ENAC channel blockers like amiloride and triamterene, which directly interfere with sodium entry through epithelial sodium channels. Toxicities can include hyperkalemia, hyperchloremic metabolic acidosis, and kidney stones.

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    © All Rights Reserved
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    POTASSIUM-SPARING DIURETICS

    Drug Name Clinical Use Phacmacodynamics Toxicity


    Mineralocorticoid
    receptor antagonist
    Spironolactone --Primary aldosteronism (Conn’s -reduce Na + absorption in the collecting  Hyperkalemia
    syndrome, tubules and ducts.  Hyperchloremic Metabolic Acidosis
    ectopic adrenocorticotropic -Potassium absorption (and K + secretion)  Gynecomastia
    hormone production) at this site is regulated by aldosterone  Acute Renal Failure
    Eplerenone --secondary hyperaldosteronism -Spironolactone and eplerenone bind to  Kidney Stones
    (evoked by heart failure, hepatic mineralocorticoid receptors and blunt Contraindications:
    cirrhosis, nephrotic syndrome, or aldosterone activity.  Hyperkalemia
    other conditions associated with  Chronic renal insufficiency
    diminished effective intravascular  Liver diseases—impaired metabolism of
    volume). triamterene/spironolactone
     Strong CYP3A4 inhibitors
    (Erythromycin, fluconazole, diltiazem
    and grapefruit juice) can markedly
    increase blood level of eplerenone but
    not spironolactone

    ENAC Channel blockers

    Amiloride -Amiloride and triamterene do not block


    aldosterone, but instead directly interfere
    with Na + entry through the epithelial Na +
    Triamterene
    channels (ENaC) in the apical membrane
    of the collecting tubule.
    -reduce Na + absorption in the collecting
    tubules and ducts
    -Potassium absorption (and K + secretion)
    at this site is regulated by aldosterone

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