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1. Erica is an 18-year-old in her first year of university. One day while she was watching a video in class, Erica started to hear what
she thought was music playing. Suddenly, she began shaking in her seat and fell to the floor. After the incident ended, one of her
classmates helped her to the campus medical center, where she was later diagnosed as having:
a. Huntington
disease.
b. Parkinson
disease.
c. epilepsy.
d. myasthenia
gravis.
ANSW c
ER:
4. René Descartes believed that _____ carried signals through the nervous system.
a. neurons
b. phlegm
c. the pineal
gland
d. cerebrospinal
fluid
ANSW d
ER:
6. Nineteenth-century scientists Fritsch and Hitzig discovered that electrical stimulation of the neocortex leads to:
a. hearing
sounds.
b. movements.
c. seizures.
d. seeing
patterns.
ANSW b
ER:
7. Electricity is a flow of electrons from a body that contains a higher charge (more electrons) to a body that has a lower charge (fewer
electrons). The body containing the higher electrical charge is called a:
a. positive
pole.
b. negative
pole.
c. dipole.
d. ground
pole.
ANSW b
ER:
9. In 1874, the physician Roberts Bartholow directly stimulated a _____ brain with electricity.
a. dog
b. rabbi
t
c. huma
n
d. cat
ANSW c
ER:
10. When Richard Caton first measured fluctuations on a voltmeter from electrodes placed on the scalp of a human subject, he was
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13. Because the giant axons of the squid are nearly _____ in diameter, they were used to record electrical activity in neurons for the
first time.
a. 1
centimeter
b. 1
millimeter
c. 5
millimeter
s
d. 0.1
millimeter
ANSW b
ER:
15. Neurons in most animals, including humans, are approximately _____ micrometers in diameter.
a. 1 to 20
b. 0.01 to
0.2
c. 100 to
200
d. up to 1
ANSW a
ER:
16. _____ won the Nobel Prize in 1963 for being the first to describe the electrical activity of neurons.
a. Young
b. von Helmholtz
c. Hodgkin and
Huxley
d. Watson and
Crick
ANSW c
ER:
17. Recording from single neurons was made possible by the invention of:
a. the electroencephalogram and the
voltmeter.
b. the oscilloscope and the voltmeter.
c. the EEG and the microelectrode.
d. the oscilloscope and the
microelectrode.
ANSW d
ER:
18. Microelectrodes can:
a. be made from glass.
b. be made from wire.
c. have a tip as small as 0.001
millimeter.
d. All of the answers are correct.
ANSW d
ER:
20. To measure the voltage across the cell membrane, you would normally:
a. insert two electrodes into the axon and measure the voltage difference.
b. place one electrode on the outer surface of an axon's membrane and another inside the axon and measure
the voltage difference.
c. place two electrodes on the outer surface of the axon's membrane and measure the voltage difference.
d. All of the answers are correct.
ANSW b
ER:
21. When a substance moves from an area of high concentration to an area of low concentration, it is an example of a(n):
a. concentration gradient.
b. voltage gradient.
c. ionic translocation.
d. None of the answers is
correct.
ANSW a
ER:
22. The movement of ions from an area of high concentration to an area of low concentration through random motion is called:
a. a concentration
gradient.
b. a voltage gradient.
c. diffusion.
d. ionic translocation.
ANSW c
ER:
26. Positively charged ions are called _____, while negatively charged ions are called _____.
a. proteins;
anions
b. anions;
cations
c. cations;
anions
d. axons;
neurons
ANSW c
ER:
30. At rest, the concentrations of _____ are higher inside of a neuron, whereas the concentrations of _____ are higher outside of a
neuron.
a. potassium (K+);
sodium (Na+)
b. sodium (Na+);
potassium (K+)
c. potassium (K+);
chloride (Cl–)
d. potassium (K+); anions
(A–)
ANSW a
ER:
33. The negative charge inside the cell membrane is largely a product of the presence of negatively charged:
a. potassium ions.
b. sodium ions.
c. protein anions.
d. All of the answers are
correct.
ANSW c
ER:
34. The sodium–potassium pump _____ exchanges three _____ for two _____.
a. continuously; intracellular Na+;
extracellular K+.
b. continuously; intracellular K+;
extracellular Na+.
c. continuously; extracellular Na+;
intracellular K+.
d. intermittently; intracellular K+;
extracellular Na+.
ANSW a
ER:
35. When the neuron is at rest, _____ channels are normally closed, whereas _____ is free to enter and leave the cell.
a. K+;
Na+
b. Cl–;
Na+
c. Na+;
K+
d. K+;
Cl–
ANSW c
ER:
36. There are approximately _____ as many K+ ions inside a cell as outside it.
a. 20
times
b. 2 times
c. one-
tenth
d. half
ANSW a
ER:
41. Small voltage fluctuations in the cell membrane that occur in the vicinity of the axon are called:
a. action
potentials.
b. graded
potentials.
c. ion
fluctuations.
d. nerve
impulses.
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42. Depolarization is primarily linked with _____, whereas hyperpolarization is mainly linked with _____.
a. sodium;
calcium
b. potassium;
sodium
c. sodium;
chloride
d. chloride;
potassium
ANSW c
ER:
43. A change in the resting potential from –70 mV to –50 mV typically results in:
a. an excitatory postsynaptic
potential.
b. repolarization.
c. an action potential.
d. hyperpolarization.
ANSW c
ER:
45. Tetraethylammonium (TEA):
a. blocks potassium channels.
b. blocks sodium channels.
c. blocks chlorine channels.
d. neutralizes large protein
molecules.
ANSW a
ER:
47. The voltage of a neural membrane that is sufficient to cause an action potential is approximately _____; it is called a _____.
a. –70 mV; resting
potential
b. –50 mV; graded
potential
c. –65 mV; threshold
potential
d. –50 mV; threshold
potential
ANSW d
ER:
48. The action potential normally consists of the summed current changes caused by the _____ and the _____.
a. inflow of sodium; outflow of
potassium
b. outflow of sodium; inflow of
potassium
c. inflow of calcium; outflow of
potassium
d. inflow of sodium; outflow of
chloride
ANSW a
ER:
53. _____ channels are less sensitive than _____ channels, so during an action potential, they open more slowly but remain open
longer.
a. Calcium;
sodium
b. Sodium;
potassium
c. Chloride;
sodium
d. Potassium;
sodium
ANSW d
ER:
54. _____ channels are more sensitive than _____ channels, so they open first during the action potential.
a. Calcium; potassium
b. Potassium; calcium
c. Sodium; potassium
d. All channels are equally
sensitive.
ANSW c
ER:
60. The magnitude of an action potential (AP) is measured near the axon hillock using an electrode and then measured again 2 mm
farther down the axon. Compared to the AP measured near the axon hillock, the AP 2 mm farther down the axon is:
a. larger.
b. smaller.
c. of the same
magnitude.
d. completely
nullified.
ANSW c
ER:
64. Because of refractory periods, the maximum firing rate of a neuron is approximately _____ impulses per second.
a. 500
b. 100
0
c. 100
d. 200
ANSW d
ER:
65. An action potential usually goes only in one direction in an axon because:
a. the ions can flow only in one direction.
b. the refractory periods force the impulse to go in
one direction.
c. the ion flow is attracted to chemicals in the
synaptic knob.
d. autoreceptors inhibit backward flow of ions.
ANSW b
ER:
66. Which of the following is NOT one of the important reasons for refractory periods in neurons?
a. They limit the firing rate of the neuron.
b. They force nerve impulses to travel in one direction.
c. They increase the sensitivity of the neuron.
d. They allow time for the neuron to reset prior to another
action potential.
ANSW c
ER:
67. _____ produce(s) myelin in the peripheral nervous system, whereas _____ produce(s) myelin in the central nervous system.
a. Ependymal cells;
Schwann cells
b. Astroglia; oligodendroglia
c. Oligodendroglia;
Schwann cells
d. Schwann cells,
oligodendroglia
ANSW d
ER:
68. Myelination of axons in humans makes up for the _____ in our nervous system.
a. small axons
b. large axons
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72. On larger myelinated axons, nerve impulses can reach speeds of up to _____ meters per second.
a. 10
0
b. 50
c. 12
0
d. 30
ANSW c
ER:
74. Melissa, a 23-year-old woman, has been having tingling sensations in her right arm and leg for a few weeks. Today, when she
woke up, she realized that she could barely move her right arm. She had a similar set of symptoms a couple of years ago, but they
went away, so she thought everything was fine. Your advice to Melissa is to go to the doctor because she may have:
a. the flu.
b. a brain tumor.
c. multiple
sclerosis.
d. Huntington
disease.
ANSW c
ER:
76. Which technology is used to observe the plaque that forms at sites of myelin loss in patients suffering from multiple sclerosis?
a. ultrasound
b. optogenetics
c. magnetic resonance imaging
(MRI)
d. computer tomography (CT
scan)
ANSW c
ER:
77. The speed at which nerve impulses travel down an axon are greatly increased by:
a. myelin.
b. refractory periods.
c. the length of the
axon.
d. calcium channels.
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79. A brief depolarization of the neuronal membrane that makes it more likely that the neuron will fire an action potential is called:
a. saltatory conduction.
b. an inhibitory postsynaptic potential
(IPSP).
c. an excitatory postsynaptic potential
(EPSP).
d. spatial summation.
ANSW c
ER:
80. A brief hyperpolarization of the neuronal membrane that makes it less likely that the neuron will fire an action potential is called:
a. saltatory conduction.
b. an inhibitory postsynaptic potential
(IPSP).
c. an excitatory postsynaptic potential
(EPSP).
d. spatial summation.
ANSW b
ER:
81. The final pathway that the nervous system uses to produce behavior is the:
a. interneuron
.
b. motor
neuron.
c. glial
neuron.
d. Schwann
cell.
ANSW b
ER:
83. EPSPs are associated with _____, whereas IPSPs are associated with _____.
a. opening of sodium channels; opening of
potassium channels
b. opening of sodium channels; closing of
potassium channels
c. closing of sodium channels; opening of
potassium channels
d. opening of calcium channels; closing of
potassium channels
ANSW a
ER:
88. Two EPSPs occurring close together in time and location on the cell membrane is an example of:
a. spatial summation.
b. temporal summation.
c. both spatial and temporal
summation.
d. neither spatial nor temporal
summation.
ANSW a
ER:
91. For an EPSP to cause another action potential, the stimulation must reach the _____, which is (are) rich in voltage-sensitive ion
channels.
a. initial
segment
b. cell body
c. dendrites
d. terminal
buttons
ANSW a
ER:
93. The _____ acts in a way similar to a democracy in that it "counts votes" from incoming EPSPs and IPSPs, and if there is enough
excitation, an action potential will fire.
a. axon
hillock
b. dendrite
c. soma
d. ion
channel
ANSW a
ER:
94. _____ is the term used to denote reverse movement of the action potential into the dendrites.
a. EPSP reversal
b. Back propagation
c. Inverse IPSP
d. None of the answers is
correct.
ANSW b
ER:
95. _____ may play a role in the neural plasticity that is associated with learning.
a. Spatial summation
b. Back propagation
c. Temporal summation
d. The relative refractory
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96. _____ combines genetics and light to control targeted cells in living tissue.
a. Photogenetics
b. Optogenetics
c. Infragenetics
d. None of the answers is
correct.
ANSW b
ER:
97. Research on optogenetics and light-sensitive ion channels has revealed that channelrhodopsin-2 can be used to _____ neurons, and
halorhodopsin can be used to _____ neurons.
a. hyperpolarize;
depolarize
b. depolarize;
hyperpolarize
c. destroy; depolarize
d. depolarize; destroy
ANSW b
ER:
104. The neurotransmitter-activated ion channels on muscle end plates differ from other ion channels in that:
a. they have a different resting membrane
potential.
b. they allow only K+ to leave the neuronal
membrane.
c. they allow only Cl–? to leave the neuronal
membrane.
d. K+ and Na+ enter and leave through the same
channels.
ANSW d
ER:
107. _____ is a disease that has been linked with the death of _____.
a. Amyotrophic lateral sclerosis; sensory
neurons
b. Myasthenia gravis; sensory neurons
c. Amyotrophic lateral sclerosis; spinal
motor neurons
d. Myasthenia gravis; interneurons
ANSW c
ER:
108. Alex is 53 years old and has had weakness in his throat and chest for a few months. Now he is also starting to have general weakness in his arms
and legs. The weakness in his legs has gotten so bad that yesterday he fell down when walking across his living room. Alex appears to be showing
early signs of:
a. Parkinson disease.
b. amyotrophic lateral sclerosis (Lou Gehrig
disease).
c. Huntington disease.
d. Alzheimer disease.
ANSW b
ER:
110. _____ is often accompanied by drooping eyelids, difficulty swallowing, and general fatigue.
a. Huntington disease
b. Tay-Sachs disease
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