Biof325 Exam 1answers

GENETICS – BIOf325
Summer 2010
Prof: Janice Fischer
EXAM #1
June 18, 2010
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Name Janice Fischer
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READ THE QUESTIONS CAREFULLY. You need to answer my question –
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not one that you make up that you like better.
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*IF THE INSTRUCTIONS SAY TO CIRCLE YOUR ANSWER AND NOTHING
IS CIRCLED or MORE THAN ONE OBJECT IS CIRCLED, YOU WILL GET
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ZERO POINTS – so don’t do that!

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* IF THE INSTRUCTIONS SAY TO ANSWER IN ONE WORD AND THERE

IS MORE THAN ONE WORD PRESENT – YOU WILL GET ZERO POINTS-
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so don’t do that!
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* You don’t have a calculator – so if there is an equation – leave it that

way.
sihs fi is
Th
In case the reason for these instructions is not obvious – it’s because
you cannot write down a variety of answers and expect me to choose the
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right one from among them. You need to choose a single answer. Do that
by circling it – especially if you have lots of stuff written on your
paper.
https://www.coursehero.com/file/5959477/BIOf325-EXAM-1-ANSWERS/
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1. A plant with the genotype AaBbCcDdEeFfGgHhIiJj self-fertilizes. Assume that
all of the alleles behave according to Mendel’s two laws.
A. How many genetically distinct gamete types are produced by each parent?
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(circle your answer) (6 pts.)
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210
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B. At what frequency are ABCDEFGHIJ gametes produced? (circle your answer)
(6 pts.)
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1/210
vioau
aC d s
vi haryere
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arle is stu
C. What is the frequency of AABBCCDDEEFFGGHHIIJJ plants among the progeny?

(circle your answer) (6 pts.)
sihs fi is
1/410
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2. A typical Mendelian monohybrid cross in pea plants is shown below. The
phenotype associated with allele “A” is three leaves per inch of stem, and the
phenotype associated with allele “a” is one leaf per inch of stem.
P AA X aa
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F1 Aa (self)
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F2
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er ans blu
A. What are the genotypes of the gametes produced by the F1? (3 pts.)
A and a
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B. At what frequency is each gamete type in the F1 produced? (3 pts.)
f(A) = f(a) = 1/2
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C. If A is completely dominant to a:
• What phenotypes are present in the F2? (2 pts.) three per inch, one per
vioau
inch
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• Label each phenotype with a frequency. (2 pts.) 3/4 three, 1/4 one
vi haryere
• Label each phenotype with a genotype. (2 pts.) AA or Aa = three,

aa = one
D. If A and a are incompletely dominant:
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• What phenotypes are present in the F2? (2 pts.)

arle is stu
three per inch, two per inch, one per inch

• Label each phenotype with a frequency. (2 pts.)
1/4 three per inch, 1/2 two per inch, 1/4 one per inch
sihs fi is
• Label each phenotype with a genotype. (2 pts.)

Th
three per inch = AA, two per inch = Aa, one per inch = aa
E. If A and a are co-dominant:

• What phenotypes are present in the F2? (2 pts.)
Th
three per inch, patches of three per inch and one per inch, one per inch
• Label each phenotype with a frequency. (2 pts.)
1/4 three, 1/2 patches, 1/4 one
• Label each phenotype with a genotype. (2 pts.)
three per inch = AA, patches = Aa, one per inch = aa
3. In the dihybrid cross shown below, genes A and B are linked with 3 map units
between them. Allele A is completely dominant to a, allele B is completely dominant
to b, and the A and B genes affect different traits.
P AABB x aabb
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F1 AaBb (self)
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F2
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A. What are the gamete genotypes produced by the F1? (3 pts.)
AB, Ab, aB, ab
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B. At what frequency is each gamete type above produced? (3 pts.)
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(RF=3%)
f(AB) = 48.5% f(ab) = 48.5%
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f(Ab) = 1.5% f(aB) = 1.5%
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C. How many phenotypic classes are there in the F2? (3 pts.) 4
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D. What is the genotype corresponding to each class in C? (3 pts.)

A_B _ A _ bb aa B_ aabb
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E. What is the phenotypic ratio of the F2? (6 pts.)

vi haryere
ed S d
arle is stu
sihs fi is
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4. In a hypothetical diploid organism, squareness of cells is due to a threshold
effect: more than 50 units of “square factor” per cell will produce a square
phenotype, and less than 50 units will produce a round phenotype.
Allele sf+ is a wild-type allele that encodes the square factor. Each sf+ allele
contributes 40 units of square factor; thus sf+/sf+ homozygotes have 80 units and
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are phenotypically square. A mutant allele sf- arises; it is an amorph, contributing
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no square factor at all.
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A. Which allele is dominant, sf+ or sf- ? (6 pts.)
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sf-
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B. What is the word used to describe a gene that behaves genetically in the way
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that the “sf gene” behaves. (6 pts.)
(the answer MUST be a single word)
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haploinsufficiency
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5. Muscular dystrophy is a disease carried by an X-linked recessive allele, called d,

that is 100% penetrant. The wild-type allele is D. D encodes a protein called
Dystrophin that is made in muscle cells, and does not travel between cells.
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Would a Dd individual display the disease phenotype?
A. Circle one answer: (6 pts.)

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MAYBE
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B. There is a single phenomenon that is more relevant to your answer to 5A than

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anything else. What is that phenomenon? (6 pts.)

(3 words maximum)
Barr body formation or X chromosome inactivation
6. The following pedigree shows the inheritance of blindness:
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A. The disease allele is 100% penetrant. Using the information from generations I
and II only, is the disease allele most likely dominant or recessive? (4 pts.)
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recessive
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B. Using the information from all three generations on the pedigree diagram, I
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think that the genotypes of individuals II-7 and II-8 are: (6 pts.)
vi haryere
AAbb (II-7) and aaBB (II-8)

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C. What one word describes the phenomenon illustrated by the production of all
unaffected individuals in generation III ? (6 pts.) complementation
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BONUS QUESTION
Do you know for certain that exactly one quarter of your genes come from each of
your four grandparents?
A. NO
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B. There are two different events that happen during meiosis that are relevant to
the answer to this question. What are these two events?
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1. recombination between non-sister chromatids, which leads to mixing of alleles on
maternal and paternal homologs
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2. random alignment of maternal and paternal homologous chromosomes with
respect to each other prior to meiosis I, which leads to random assortment of
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maternal and paternal homologs into gametes
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aC d s
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arle is stu
sihs fi is
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GENETICS – BIOf325

ZERO POINTS – so don’t do that!

* IF THE INSTRUCTIONS SAY TO ANSWER IN ONE WORD AND THERE

* You don’t have a calculator – so if there is an equation – leave it that

C. What is the frequency of AABBCCDDEEFFGGHHIIJJ plants among the progeny?

• Label each phenotype with a genotype. (2 pts.) AA or Aa = three,

• What phenotypes are present in the F2? (2 pts.)

three per inch, two per inch, one per inch

• Label each phenotype with a genotype. (2 pts.)

E. If A and a are co-dominant:

D. What is the genotype corresponding to each class in C? (3 pts.)

E. What is the phenotypic ratio of the F2? (6 pts.)

5. Muscular dystrophy is a disease carried by an X-linked recessive allele, called d,

Would a Dd individual display the disease phenotype?

A. Circle one answer: (6 pts.)

B. There is a single phenomenon that is more relevant to your answer to 5A than

anything else. What is that phenomenon? (6 pts.)

Barr body formation or X chromosome inactivation

AAbb (II-7) and aaBB (II-8)

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