Name of Drug Mechanism of Action Indication Contraindications Side Effects Nursing Responsibilities

Generic Name: Bind to bacterial cell wall Treatment of It is effective Hypersensitivity to GI: Before:
Cefuroxime membrane, causing cell for the treatment of cephalosporins and related Diarrhea,
death penicillinase-producing antibiotics; pregnancy nausea, antibiotic- • Determine history of hypersensitivity reactions
Brand Name: Neisseria gonorrhoea. (category B), lactation. associated colitis. to cephalosporins, penicillins, and history of
Ceftin Therapeutic Effects: Effectively treats bone and allergies, particularly to drugs, before therapy
Bactericidal action joint infections, bronchitis, Skin: is initiated.
Classification of Drug: meningitis, gonorrhea, otitis Rash, pruritus, • Lab tests: Perform culture and sensitivity tests
media, pharyngitis/tonsillitis, urticaria. before initiation of therapy and periodically
Therapeutic: sinusitis, lower respiratory during therapy if indicated. Therapy may be
Anti-infectives tract infections, skin and soft Urogenital: instituted pending test results. Monitor
tissue infections, urinary tract Increased serum periodically BUN and creatinine clearance.
Pharmacologic: infections, and creatinine and
Second generation is used for surgical BUN, decreased
Cephalosporins prophylaxis, reducing or creatinine During:
eliminating infection. clearance.
Pregnancy Catergory B • Inspect IM and IV injection sites frequently for
Hema: signs of phlebitis.
Tablets: 125mg, 250mg, Hemolytic anemia • Monitor for manifestations of hypersensitivity.
500mg Discontinue drug and report their appearance
Powder for injection: MISC: promptly.
750mg, 1.5g, 7.5g Anaphylaxis • Monitor I&O rates and pattern: Especially
Premixed containers: 750 important in severely ill patients receiving high
mg/50ml, 1.5g/50ml doses.
• Report any significant changes.
• Report onset of loose stools or diarrhea.
Although pseudomembranous colitis rarely
occurs, this potentially life-threatening
complication should be ruled out as the cause
of diarrhea during and after antibiotic therapy.

After:

• Instruct patient to take medication around the

clock at evenly spaced times and to finish the
medication completely, even if feeling better
• Advise patient to report signs of superinfection
and allergy
• Instruct patient to notify health professional if
fever and diarrhea develop