JORNADAL, MABELLENE G.

3DMT

AUTOIMMUNE DISEASES

SPECIFICITY DISEASE TARGET TISSUE

Hashimoto’s thyroiditis Thyroid

Graves’ disease ThyroiD
Pernicious anemia cells Gastric parietal
Addison’s disease Adrenal glands
Organ-Specific Type I diabetes mellitus Pancreas
MG Nerve-muscle synapses
↓ MS
Autoimmune hemolytic anemia
Myelin sheath of nerves
Red blood cells
Systemic Idiopathic thrombocytopenic purpura Platelets
Goodpasture’s syndrome Kidney, lungs
RA Joints, lungs, skin
Scleroderma Skin, gut, lungs, kidney
SLE Skin, joints, kidney, brain, heart, lungs

OTHER AUTOIMMUNE DISEASES

DISEASE ORGAN OR TISSUE IMMUNOLOGIC MANIFESTATIONS

Addison’s disease Adrenal glands Antibody to adrenal cells

Autoimmune hemolytic anemia Red blood cells Antibody to red blood cells
Autoimmune thrombocytopenic purpura Platelets Antiplatelet antibody
Crohn’s disease Intestines Inflammatory infiltrate of T and B cells:
mechanism unknown
Disseminated encephalomyelitis Central nervous system Sensitized T cells
Pernicious anemia Stomach Parietal cell antibody, intrinsic factor antibody
Poststreptococcal glomerulonephritis Kidney Streptococcal antibodies that cross-react with
kidney tissue
Rheumatic fever Heart Streptococcal antibodies that cross-react with
heart tissue
Scleroderma Connective tissue Antinuclear antibodies: anti-Scl-70,
anticentromere antibody
Sjögren’s syndrome Eyes, mouth Antinuclear antibodies, RA factor antisalivary
duct antibodies,
antilacrimal gland antibodies
Sarcoidosis Multisystem granulomas, Activation of T lymphocytes
pulmonary manifestations