Transmitted via contaminated

saliva of infected animal through

bites, scratches, mucosal
exposure, wounds, transplanted
neurologic tissue

Deep muscle inoculation

Endogenous muscle micro RNA

bind to viral transcripts

Limits viral replication and

protein production

Virus evades detection by

antigen presenting cells such as
macrophages

Prolonged incubation period

Virus reaches neuromuscular

junction

Taken up by motor neuron and

propagates along the axons towards the
spinal cord (retrograde transport)

Virus elicits inflammation in

motor neuron

Progression of Reaches the spinal cord and

Prodromal Period
Encephalitis travel towards brain tissue

Pathognomonic for Rabies:

Anisocoria
Travels to Salivary gland and Pain and Paresthesia
Fixed Pupillary Dilation
Nonspecific S/S:
Optic Neuritis other visceral organs
Fever & Flu-like illness
Facial Palsy (Anterograde transport)
Other Symptoms
Mydriasis
Malaise Anorexia
Excessive Salivation and
Headaches Fever
Lacrimation
Chills Pharyngitis
Nausea Emesis
Diarrhea Anxiety
Agitation Insomnia
Depression

Progression of Delirium, Acute Neurologic Phase

Stupor, and Coma

Furious Rabies:
Agitation Hyperactivity
Death occurs from global Restlessness Thrashing
neurologic and organ Biting Confusion
dysfunction Hallucination Seizures
Pathognomonic for Rabies:
Hydrophobia and Aerophobia
Autonomic instability:
Fever Tachycardia
Hypertension Hyperventilation