1

Homeostasis is brought about by Negative feedback mechanism (correction)

Example: Blood glucose Regulation (DSE 2012 , 2015 , 2018)

More Insulin / Pancreas

Less glucagon Secretes Detected by

Stimulates
Blood glucose level 

1. the uptake of glucose (*)

2. the conversion of glucose to After a meal
glycogen in liver cells Normal blood
3. the respiration of glucose glucose Level
Fasting
in body cells (consume glucose)

Blood glucose level 

1. the conversion of glycogen to
glucose
2. less oxidation of glucose

Promotes

Secretes Detected by
Less Insulin /
**Pancreas
More Glucagon

rises to a higher / later peak

longer time back to

basal level
sharper rise
With sufficient amount of
insulin, the body cells can … (*)

A: Healthy person

B: Type 1 insulin dependent diabetes (Plasma glucose  but no/ very low insulin level, despite an increase in plasma glucose level)
The patient fails to produce normal amount of insulin

C: Type 2 non-insulin dependent diabetes (Plasma glucose   a shaper increase in the plasma insulin level, yet his plasma
glucose level remains higher than normal.) The patient is insensitive to insulin
 2

Two patterns of response shown by the human body towards stimuli of different nature
are outlined below:

Pattern A
central
stimulus receptor nervous effector response
system

e.g. stepping e.g. withdrawal

on a sharp nail of foot

Pattern B

stimulus hormone response

e.g. increase in e.g. decrease in

blood glucose blood glucose
level level

Homeostasis

https://www.youtube.com/watch?v=Iz0Q9nTZCw4