What is difference?

Unlike MSCs obtained by original

REC
methods, REC does not contain any

Highly purified Human Mesenchymal Stem Cells

impurity cells and can be amplifiably
cultured for long term period. In
addition, differentiation/migration
-Rapidly Expanding Cell abilities are maintained even after
incubation for a certain time. It can be
Mesenchymal stem cells (MSCs) are the tissue stem cells with a variety of differentiation ability such as bone, also stored as frozen cells and can be
cartilage and fat. Because there are few ethical problems associated with cell collection, MSCs are expected used for research at any time. That is,
to be available for clinical application next to hematopoietic stem cells. Also MSCs can be isolated relatively MSCs with guaranteed cell quality can
be used as cells for a basic research or
easily, they are widely used as biomaterials such as for local transplantation after differentiation induction
as cells for a clinical research.
into cartilage and bone in vitro. Some doctor-led clinical researches have been conducted at Shimane
University.
Currently, MSCs are isolated based on adherence to plastic and it makes difficult to maintain cell quality
constant after cell culture. PuREC was established for the purpose of providing high-quality MSCs for basic
and clinical research use with its unique method of cell isolation without losing cell functions.
Rapidly Expanding Cell (REC) has following properties: A) homogeneous cell populations, B) does not indicate
cellular senescence, C) most of the cells in the proliferative phase, D) high differentiation ability (especially to
Comparison with other companies' products
fat) and E) high migration ability. It can be said that REC is a high quality and purity hMSC, which is different REC has a high ability to differentiate into fat, osteoblasts and cartilage, has a uniform
from conventional MSCs. (Mabuchi et al. Stem Cell Reports 2013) Proliferation cell shape and high migration.

Number of Cell ※ 1 Before

※1 Fat Osteoblast Cartilage
(4 days after culture) differetiation

REC has very high proliferative potential and it is

12

Differentiation possible to amplify from 1 to 1012 cells.

Compared to conventional MSCs, REC *

differentiates into bone and fat cells at a very ※2

high rate.

Bone Fat
Proliferation
12
*Conventional MSC

Differentiation Migration
Conventional MSC

※ 1: 5x105 of Frozen MSC seeded　※ 2: Not Differentiated

Pluripotent Cells
Other company Other company

Migration Bone marrow ※

Source Fat
Migration: REC’s cell morphology is small and uniform in size and also has high Others Decidua and pulp Decidua and others Skin
migratory. Even in an intravenous administration, it is not trapped in lung capillaries Single cell Centrifugal separation Single cell
like conventional MSCs. Separation (cell sorter) Adhesion culture
Adhesion culture (Limitting dilution method)

■ MSC Characters
Cell morphology Uniform Ununiform Ununiform Uniform
Proliferation: Self-renewal ability with
Bone
undifferentiating ability
Immunodeficient animals
Differen- Cartilage/Fat
Differentiation: Differentiation ability into various Cultured MSC tiation
cells Others Nerve/Muscle △ Nerve/Liver △ Myocardium
Migration: Ability to circulate throughout a
body to migrate and engraft to a
iPS cells establishment

proper location Proliferation

Use: Action that leads to curing

difficult-to-treat diseases: bone Migration
disease, immune disease, chronic
inflammatory disease etc.
Transplantation Not only local transfer but also Clinical application planed in 2018
method: intravenous transfer is available
※ Adipose tissue Derived Regenerative Cells: Adipose tissue-derived regenerative cell

※ REC meets all above requirements.

 Price
Source Catalog No. Description Number Price
PRC-010 5 x 105 / vial ￥110,000 -
Human Bone
PRC-020 REC(Rapidly Expanding Cell) 1 x 106 / vial ￥168,000 -
Marrow
PRC-015 5 x 105 / vial ｘ 5 units ￥440,000 -
Monoclonal antibody that specifically recognizes REC and medium for REC will be released sequentially.

REC Highly purified Human Mesenchymal Stem Cells

-Rapidly Expanding Cell

We deal with the products with “For Research Use Only” or “For laboratory Use Only. Please do not
use it as medicine or a diagnostic equipment. “For Research Use Only” is only used for a basic/clinical
research.

■ Manufacturer：PuREC Co., Ltd.

〒 693-8501
89-1 Enya-cho, IZUMO 693-8501 JAPAN
Faculty of Medicine, SHIMANE University
TEL: +81.50.3717.0961
http://www.purec.jp ■ Distributor

※ PuREC was establised as SHIMANE University venture company in January 2016.

Corporate philosophy
We aim to develop a safe and an effective stem cell therapy utilizing cell
functions, proliferation, differentiation, migration ability and cellular
senescence which MSC should originally have.

■ 輸入元・総販売元
■ Sole Agent：Bay bioscience Co., Ltd.
5-2-5 Minatojima Minamimachi
ベイ バイオサイエンス株式会社
Chuo-ku, KOBE 650-0047 JAPAN
テクニカルサポー ト　TEL：078-304-5881
TEL: +81. 78.304.5881
HomeEmail:
Page: info@baybio.co.jp　
http://www.baybio.co.jp 2016.08.16
http://www.baybio.co.jp