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Answer: levigation
Answer:
I. Douche
II. Dusting powder
III. Insufflation
Answer: 12-16
Answer:
I. Gelatin is obtained by the partial hydrolysis of collagen obtained from the skin,
white connective tissue and bones of animals.
II. Although gelatin is insoluble in cold water, it does soften through the
absorption of up to ten times the weight of the water.
III. Gelatin is soluble in hot water and in warm gastric fluid; a gelatin capsule
rapidly dissolves and exposes its contents.
10. Prolonged exposure to high humidity can affect in vitro dissolution of capsules
containing:
Answer:
I. tetracycline
II. Chloramphenicol
III. Nitrofurantoin
12. The following statement/s is/are true for soft gelatin capsules (SGC):
Answer:
I. SGC is made of gelatin to which glycerin or a polyhydric alcohol has been
added.
II. Methyl parabens can be used as preservatives to retard microbial growth.
13. Types of liquids that may be encapsulated into soft gelatin capsules include the
following:
Answer:
I. Vegetable and aromatic oils
II. Propylene glycol
Answer:
I. Are harmless in the quantities used
II. Do not exceed the minimum amounts required to provide their intended effect
III. Do not impair the product’s bioavailability, therapeutic efficacy or safety
15. These are compressed tablets coated with substances that resist dissolution in
gastric fluid but integrate in the intestine.
Answer: Enteric-coated tablets
16. This type of coating imparts the same general characteristics as sugar coating with
the added advantage of greatly reduced time period required for the coating operation.
17. These tablets were originally used by physicians in the extemporaneous preparation
of parenteral solutions.
Answer:
I. Have delayed-release features
II. Are intended to pass through the stomach intact to disintegrate and release their
drug-content for absorption along the intestines
Answer:
I. Shellac
II. Cellulose acetate phthalate
III. Polyvinyl acetate phthalate
Answer:
I. Tablet diameters and shapes are determined by the die and punches used in the
compression of the tablet.
II. They are made from powdered, crystalline or granular materials, alone or in
combination with binders, disintegrants, controlled-release polymers, lubricants,
diluents and colorants.
21. This is a method of preparing tablets in which the powder mixture is compacted in
large pieces and subsequently broken down or sized into granules.
Answer:Direct compression
23. The problems most commonly encountered during direct compression include:
Answer:
I. Capping
II. Splitting
III. Lamination
24. For chemicals which do not possess cohesive and free-following properties, the
following excipients could be used to impart necessary qualities for the production of
tablets b direct compression.
Answer:
I. Spray-dried lactose
II. Magnesium stearate
III. Fume silicon dioxide
25. The following statement/s is/are true for wet granulation method:
Answer:
I. Liquid binder is added to the powder mixture to facilitate the adhesion of the
powder particles
II. Granules may be dried in thermostatically controlled ovens which constantly
record the time, temperature and humidity.
Answer:
I. Improving the flow of granulation in the hopper to die cavity
II. Preventing the adhesion of the tablet formulation to the punches and dies during
compression
III. Reducing friction between the tablet and die wall during the tablet’s ejection from
the tablet machine
Answer:
I. Preblends the formulation powder, including active ingredients, fillers,
disintegrants, in a bed by fluidized air.
II. Granulates the mixture by spraying onto the fluidized powder bed, suitable liquid
binder, as an aqueous solution of acacia, hydroxypropyl cellulose or povidone
III. Drying the granulated product to the desired moisture content
Answer:
I. Ingredients that is sensitive to moisture or unable to withstand elevated
temperature during drying
II. One of the constituents, either the active ingredient or the diluents, must
have cohesive properties
29. Aspirin, which is hydrolyzed on exposure to moisture, is prepared into tablet using
the dry granulation method. Other drugs which should be prepared using this process
include:
ANSWER:
I. Ascorbic acid
II. Thiamine HCl
30. This process is a form of pelletization, which refers to the formation of spherical
particles from wet granulations.
Answer: Spheronization
31. This method consists of bringing together a highly dispersed liquid and a sufficient
volume of hot air to produce evaporation and drying of the liquid droplets.
33. This the only carbohydrate used in the preparation of compressed tablet which
possesses high heat stability.
Answer: mannitol
34. The following statement/s is/are true used in the preparation of sugar-free chewable
tablets?
Answer:
I. Mannitol is used as the excipient in most chewable tablets.
II. These tablets are formulated to disintegrate smoothly in the mouth with or
without active chewing.
III. These tablets are particularly useful for children and adults who have difficulty
swallowing other solid dosage forms
Answer:
I. Protect the medicinal agent destructive exposure to air and/or humidity
II. Mask the unpleasant taste of the drug
III. Provide special characteristics of drug release
Answer:
I. Coating may be colored to make tablets attractive and distinctive
II. Film-coating solutions may be non-aqueous or aqueous
38. This substance provides water solubility or permeability to the film to ensure
penetration by body fluids and therapeutic availability of the drug.
39. Problems encountered on the use of aqueous based film coating solution include:
ANSWER:
I. Expensive as compared to volatile solvents
II. Increased likelihood of water interference with the tablet formulation
Answer:
I. A high solid content for greater coating activity
II. Low viscosity which allows less water to be used in the coating dispersion
III. Low viscosity which permits greater coat penetration into the crevices of
monogrammed or scored tablets
41. This is a problem often encountered in film coating process characterized by
roughness of the tablet surface due to failure of spray droplets to coalesce.
42. This problem corresponds to the filling-in of the score line or indented logo on the
tablet by the film.
Answer: bridging
43. This problem is characterized by the appearance of small amounts of film fragments
flaking from the tablet surface.
Answer: picking
Answer:
I. Are small, round, solid dosage form containing a medicinal agents and intended
to be administered orally
II. Have been replaced today by compressed tablets and capsules
III. Are placed in the mouth, where they dissolve slowly, liberating the active
ingredient
45. These are forms of oral medication which are discoid-shaped solids containing the
medicinal agent in a suitably flavored base.
Answer:
I. Troches
II. Pastilles
III. Lozenges
46. This type of dosage form allows a reduction in dosing frequency to that presented
by a conventional dosage form.
Answer: Extended-release
48. This type dosage form is designed to release the drug form at a time other than
promptly after administration.
Answer: Delayed-release
49. The following statement/s hold/s true for extended-release dosage forms:
Answer:
I. There is reduction in drug blood level fluctuations.
II. There is frequency reduction in dosing
III. There is reduction in terms of adverse side effects.
50. In general, the drugs best suited for incorporation into an extended-release product
have the following characteristic/s:
Answer: Microencapsulation
52. The following statement/s is/are true when embedding drug in inert plastic matrix:
Answer:
I. The drug is granulated with an inert plastic material such as polyethylene and the
granulation is compressed into tablets
II. The compression of the tablet creates the matrix or plastic form that retains its
shape during the leaching of the drug and through its passage through the
alimentary tract.
53. The effectiveness of the hydrophilic matrix systems is based on the successive
processes of:
Answer:
I. Hydration of the cellulose polymer
II. Gel formation on the polymer’s surface
III. Tablet erosion and subsequent and continuous release of the drug
54. Which of the following statement/s on drug release form the dosage form is correct:
Answer:
The release of the drug in a drug-resin complex is dependent upon the pH and the
electrolyte concentration in the GIT.
55. These tablets are prepared so that an initial dose of drug is released immediately
followed later by a second dose.