DRUG STUDY

Generic Name:
Mefenamic Acid
Brand Name:
Aciflam
Classification:
Central nervous system agent; analgesic;
NSAID; antipyretic

Dosage:
For mild to moderate pain
500mg, 1 tab PRN

Route:
Oral route
Indications:
Relief of mild to moderate pain in acute or chronic conditions including: muscular
origin, episiorrhaphy.
Contraindications:
Hypersensitivity to drug; GI inflammation, or ulceration
Mechanism of Action:
It inhibits the synthesis of prostaglandins. Mefenamic acid shows central and peripheral
action and it owes these properties to its capacity to inhibit cyclooxygenase.
Drug to Drug Interaction:
Mefenamic acid may prolong bleeding time with oral anticoagulants. Heparin may
increase lithium toxicity; increases pharmacologic and toxic activity of phenytoin.
Side Effects:
Mild heartburn, stomach pain, diarrhea, constipation, flatus, dry mouth, nervousness.
Adverse Effects:
Anemia, edema, pruritus, rash, tinnitus; cardiovascular thrombotic events,
hepatotoxicity, renal toxicity.
Nursing Responsibilities:
1. Assess for history of allergies to the drug
2. Administer with meals to prevent GI discomfort
3. Increase fiber in diet
4. Increase fluid intake
5. Provide oral care
6. Assess daily bowel pattern
7. Assess stool consistency via Bristol stool chart
8. Monitor blood hgb levels
9. Monitor and record severity of pain using pain scale
10. Educate the patient on the adverse effects