The Innate Immune Response

With Prof. Peter J. Delves

S2031231 STUDENT, s2031231@siswa.um.edu.my

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 Learning Objectives

• Describe how cells of the innate immune response

detect and respond to a threat.

• Outline the acute phase response.

• Contrast acute and chronic inflammation.

• Discuss the role of the cellular and molecular

components of innate immunity.

S2031231 STUDENT, s2031231@siswa.um.edu.my

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 Events Occurring During the Innate Response

• Recognition of a threat infection, toxins, tissue damage

• Activation of innate immune cells and the complement system

• Production of cytokines, chemokines, acute phase proteins and defensins

• Upregulation of cell adhesion molecules

• Recruitment of cells to the site of infection or tissue damage

• Elimination of the stimulus

• Resolution of the response

• Tissue repair

S2031231 STUDENT, s2031231@siswa.um.edu.my

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 List of References

Cellular and Molecular

Immunology, 8th Edition
Abbas

S2031231 STUDENT, s2031231@siswa.um.edu.my

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S2031231 STUDENT, s2031231@siswa.um.edu.my

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