(SSUET/QR/111)

BIOMEDICAL ENGINEERING DEPARTMENT

SIR SYED UNIVERSITY OF ENGINEERING & TECHNOLOGY

COURSE INFORMATION SHEET

Session: Fall 2021
Course Title: Modeling and Simulation
Course Code: BM-331
Credit Hours: 2+1
Semester: 6th
Pre-Requisites: Physiology-I, Biomechanics
Instructor Name: Engr. Zohra Jabeen
Email and Contact Information: zohraj@ssuet.edu.pk
WhatsApp Group
Office Hours: 9:00-5:00

Mode of Teaching: Synchronous/Asynchronous/ Hybrid/  Blended

COURSE OBJECTIVE:
Fundamentals and advantages of Modeling and Simulation, types of models and Simulation , model
translation, Modeling complex systems, simulation languages, steps in simulation, model building
techniques, role of models in a study, simulation methodologies. Introduction to queuing systems,
queuing model of multi programming systems and network system.

COURSE OUTLINE:
Introduction to Modeling and Simulation. Fundamental and advantages of Modeling and Simulation.
Definition of terminologies used in modeling and simulation. Classification of models (Hybrid models,
Multi-scale modeling, and Conceptual modeling). Introduction to variety of Mathematical Models.
Mathematical model of Mechanical, electrical and biological system. Model of cardio-respiratory
system (model requirements, conceptual model), Model of circulatory system (model requirements,
conceptual and mathematical model), Model of respiratory system (model requirements,
multiple/conceptual/mathematical models), Physiological control modeling (model
requirements/conceptual/ mathematical models). Model building techniques, role of models in a study
such as electrical model of biological tissue (skin, muscles) and its implementation in electrical
impedance plethysomography. Simulation methodologies to study the effect of temperature on
implanted deep brain stimulation electrodes. Introduction to state space variable. Example of State
space equation and its relation with transfer function. Representation of fluid and biomedical system in
electrical component diagram using state space. Introduction to the software implementation of model.
Introduction to queuing systems.

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BIOMEDICAL ENGINEERING DEPARTMENT
SIR SYED UNIVERSITY OF ENGINEERING & TECHNOLOGY

COURSE LEARNING OUTCOMES (CLOs) and its mapping with Program Learning
Outcomes (PLOs):

CLO Bloom’s
Course Learning Outcomes (CLOs) PLOs
No. Taxonomy
Explain the concepts of basic Mathematical, PLO_1
Electrical, Fluidic Models, its analogous system. (Engineering C2
1
/knowledge) (Understanding)
Analyze the research problems by simulating the PLO_2 C4
2
physiological models (Problem Analysis) (Analyzing)
Demonstrate the modeling of cardiovascular
system, blood flow, heat transfer, and renal PLO_5 P3
3
clearance using simulation software tools (Modern Tool Usage) (Guided
Response)
PLO_5 A3
4 Formulate a physiological model.
(Modern Tool Usage) (Organization)
COMPLEX ENGINEERING PROBLEM/ACTIVITY:

Complex Engineering Problem Included: Yes

Details Nature and details of Complex Engineering Problem
(CEP): It will be given in Assignment # 02.

CEP will be based on CLO2 "Students have to develop

learning about one block model and implement their
knowledge to design a model on Comsol.

Attributes could be: WP1, WP3, WK5

WP1: Depth of knowledge required
WP3: Depth of analysis required
WK5: Engineering specialist knowledge
Assessment in: Assignment # 02

Complex Engineering Activity Included: Yes

Details Nature and details of Complex Engineering Problem
(CEP): It will be given in Project.

CEA will be based on CLO4 "Students have to develop

learning about physiological modeling and simulation and
implementation by obtaining a theoretical understanding of
simulation , and gaining practical experience in designing
the physiological models on comsol.

Attributes could be: EA3, EA4, WK5,

EA1: Range of resources
EA2: Level of interaction
WK5: Engineering specialist knowledge
Assessment in: Project # 1

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BIOMEDICAL ENGINEERING DEPARTMENT
SIR SYED UNIVERSITY OF ENGINEERING & TECHNOLOGY

RELATIONSHIP BETWEEN ASSESSMENT TOOLS AND CLOS:

Assessment tools CLO-1(40) CLO-2(40) CLO-3(15) CLO-4(5)

Quizzes 5%(2) 5%(2)

Assignments 7.5%(3) 7.5%(3)

Midterm Exam 37.5%(15) 12.5%(05)

Final Exam 50%(20) 75%(30)

Lab Assessment - - 100%(15) 100%(5)

GRADING POLICY:
Assessment Tools Percentage
Quizzes 5%
Assignments 5%
Midterm Exam 20%
Final Exam 50%
Lab Assessment 20%
Total 100%
Recommended Book:

 Peter Wriggers and Thomas Lenarz, “Biomedical Technology Modeling, Experiments

and Simulation”, 2018, Springer, ISBN:978-3-319-59547-4

Reference Books:
 Willem V. Meurs, “Modeling and simulation in biomedical engineering”, 2011, McGraw-Hill
Companies, ISBN: 978-07-171446-4.
 Sarah J. Pitt and James M. Cunningham, “An introduction to Biomedical Science in
Professional and Clinical Practice”, 2009, John Wiely \& Sons, ISBN: 978-0-470-05714-8.

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BIOMEDICAL ENGINEERING DEPARTMENT
SIR SYED UNIVERSITY OF ENGINEERING & TECHNOLOGY

 COURSE BREAKDOWN WITH LAB SYNCHRONIZATION:

- Both sides same Colors: Lab is synchronized with the topic
- Red Color: Lab is not synchronized (conducted before theory)
- No Color: Lab is to introduce new hardware or software
skill / Open Ended Lab / Lab is relevant to a
topic taught in pre-requisite and required for
upcoming labs
Week
Topics Laboratory Synchronization
No.
What is modeling and simulation,
1 Determine the responses of electric lines
Application of Modeling and Simulation in
of forces in different mediums.
Biomedical Engineering
Determining the responses of electric
2 Types of Models e.g. graphical model, Quantitative lines of forces in a medium by
models, Multiscale Models changing the inter-distance between
the electrodes.

Determination of thermal effect in brain

Hybrid models and its application in Biomedical
3 Engineering
produced by electrical stimulation

4 Conceptual modeling, why, when, where to use the Trace the optimum voltage by deep
conceptual model. brain stimulation.

To determine the treatment of Epilepsy

Conceptual model of cardiorespiratory system by cooling mechanism through fluid flow
5

Trace the Heart rate in Atherosclerosis by

Subdivision of Physiology models and combining of
6 basic elements of Conceptual models.
using electrical impedance
Plethysmography via micro electrodes

Things necessary before building a model.

One block model and its examples e.g. Heart,
7 muscles, eye etc.
Open ended lab

8 Midtrem Exams

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BIOMEDICAL ENGINEERING DEPARTMENT
SIR SYED UNIVERSITY OF ENGINEERING & TECHNOLOGY

Trace the heart rate in the disease artery

by varying the size of the plaque, using
9 Hierarchical and integrated Model.
the electrical impedance
plethysmography via micro electrodes.

Mathematical Models and their importance in

Biomedical engineering, Trace the response treatment of Epilepsy
10
Mathematical models of Mechanical and Electrical by cooling mechanism through fluid
systems flow.

Electrical and fluidic modeling of the blood flow

through the artery.
11 Elementary Vascular Model and Its Electrical Tracing of cooling effect on skin.
Analog

Determining the response of optimum

12 Electrical modeling of physiological System.
Electrode electrolyte interface model
13 Modeling of physiological systems
voltage of micro electrode simulation in
brain.
Optimization of size and inter-distance of
electrodes to determine heart rate through
radial artery by using electrical impedance
plethysmography

14
Examples of Physiological models The 2D flow analysis of the rupture risk
of Cerebral Aneurysms

Skin model and its application in electrical

15 Open ended lab
impedance plethysmography

Importance of modeling and simulation according to

16 Final Viva
new trends and technique

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BIOMEDICAL ENGINEERING DEPARTMENT
SIR SYED UNIVERSITY OF ENGINEERING & TECHNOLOGY

LESSON PLAN
Course Title: Modeling and Simulation
Course Code: BM-331

Week Required
Week Dates Topics Key Dates
No. Reading
11-10-2021 Meurs Chap 01
1 to Signals and Systems Pgs: 3-7
What is modeling and simulation
16-10-2021 Pgs: 7-9
Application of Modeling and
Simulation in Biomedical Engineering Meurs Chap 01
18-10-2021 Types of Models e.g. graphical model, Pgs: 10-11
2 to Quantitative models,
23-10-2021 Types of Models e.g. Multiscale Models Meurs Chap 02
Hybrid models and its application in Pgs: 19-24
Biomedical Engineering
Conceptual modeling, why to use
25-10-2021 Meurs Chap 03
conceptual model.
3 to Pages: 33-34
Conceptual modeling, when to use
30-10-2021 Pages: 37-39
conceptual model.
Conceptual modeling, where to use
01-11-2021
conceptual model. Meurs Chap 03
4 to
Things necessary before building a Pages: 39-42
06-11-2021 Assignment # 1
model
08-11-2021 Conceptual model of cardiorespiratory Meurs Chap 03
5 to system Pages: 35-39
13-11-2021 Subdivision of Physiology models Pages: 36-37
Combining of basic elements of
15-11-2021
Conceptual models Meurs Chap 03
6 to
One block model and its examples e.g. Pages: 41-42
20-11-2021 Quiz # 1
Heart, muscles, eye etc.
22-11-2021 Hierarchical and integrated Model.
Meurs Chap 04
7 to Mathematical Models and their
27-11-2021 importance in Biomedical engineering.

8 Midterm Examination

Mathematical models of Mechanical

06-12-2021 Meurs Chap 04
system
9 to Pages: 47-48
Mathematical models of Electrical Pages: 49-51
11-12-2021
systems
State Space Modeling
13-12-2021 Meurs Chap 04
Electrical and fluidic modeling of the
10 to Pages: 51-56
blood flow through the artery Pages: 70-77
18-12-2021 Assignment # 2

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BIOMEDICAL ENGINEERING DEPARTMENT
SIR SYED UNIVERSITY OF ENGINEERING & TECHNOLOGY

Electrical and fluidic modeling of the

20-12-2021
blood flow through the artery Meurs Chap 04
11 to Pages: 70-77
Elementary Vascular Model and Its
25-12-2021
Electrical Analog
27-12-2021
to Electrical modeling of physiological Thomas Heldt,
12 Chap 02
01-01-2022 System Pages: 50-57
03-01-2022
to Electrode electrolyte interface model Thomas Heldt,
13 Chap 02 Quiz # 2
08-01-2022 Modeling of physiological systems Pages: 58-67
10-01-2022 Thomas Heldt,
14 to Examples of Physiological models Chap 02
15-01-2022 Pages: 67-80
Electrical
Skin model and its application in Impedance
17-01-2022 Plethysmograp
electrical impedance plethysmography
15 to hy
The Bio Heat equation in Biomedical Nyboer
22-01-2022
engineering Pages: {811--
821
24-01-2022
16 to Revision
29-01-2022

Final Examination

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BIOMEDICAL ENGINEERING DEPARTMENT
SIR SYED UNIVERSITY OF ENGINEERING & TECHNOLOGY

LAB PLAN
Course Title: Modeling and Simulation
Course Code: BM-331
Week Required
Lab Date Objective
No. Reading
11-10-2021
1 to Determination of electric lines of forces in
16-10-2021 medium

Determining the responses of electric

2 18-10-2021
lines of forces in a medium by
to
23-10-2021 changing the inter-distance between
the electrodes.
25-10-2021
3 Determination of thermal effect in brain
to
produced by electrical stimulation
30-10-2021
01-11-2021
4
Trace the optimum voltage by deep
to
06-11-2021 brain stimulation.
08-11-2021 To determine the treatment of Epilepsy by
5 to cooling mechanism through fluid flow
13-11-2021
15-11-2021 Trace the Heart rate in Atherosclerosis by
6 to using electrical impedance
20-11-2021 Plethysmography via micro electrodes
22-11-2021
7 to Open ended lab
27-11-2021
Mid Term Examination
8

Trace the heart rate in the disease artery

9 06-12-2021
by varying the size of the plaque, using
to
the electrical impedance plethysmography
11-12-2021
via micro electrodes.
13-12-2021
10 to Trace the response treatment of Epilepsy
18-12-2021 by cooling mechanism through fluid flow.
20-12-2021
11 to Tracing of cooling effect on skin.
25-12-2021
27-12-2021 Determining the response of optimum
12 to voltage of micro electrode simulation in
01-01-2022 brain.
03-01-2022 Optimization of size and inter-distance of
13 to electrodes to determine heart rate through
08-01-2022 radial artery by using electrical impedance
plethysmography

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BIOMEDICAL ENGINEERING DEPARTMENT
SIR SYED UNIVERSITY OF ENGINEERING & TECHNOLOGY

10-01-2022
14 to The 2D flow analysis of the rupture risk
15-01-2022 of Cerebral Aneurysms
17-01-2022
15 to Open ended lab
22-01-2022
24-01-2022
16 to Lab/Project Viva
29-01-2022

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