KUMPULAN RUMUS FARKIN

1. Data Darah
 Cp = Cpoe-kt (mg/L)
 Grafik = Cp vs t
𝐶𝑝
ln⁡( )
 𝐶𝑝𝑜
t= −𝑘

 lnCp = lnCpo-kt
 Cpo = elnCpo (mg)
Cpo⁡
 AUC0-inf = (mg.jam/L)
𝑘
F.Do⁡ 𝐷 ⁡
 VD = = 𝐶𝑝𝐵𝑜 (L)
𝐶𝑝𝑜
𝐷𝐵 ⁡
 Cpo = 𝑉𝐷
VD⁡(L)⁡
 VD (%BB) = 𝐵𝐵⁡(𝐾𝐺) 𝑋100% (%)

 VD (L) = VD (L/kg)*BB(kg)
0,693⁡
 t1/2 = (jam)
𝑘
0,693⁡
 k= (/jam)
t1/2

 ClT = k*VD (L/jam)

 DB (dosis obat sisa) = VD*CP (mg)
 Durasi = takhir – tawal (jam)

2. Data Urin
a. Metode kecepatan ekskresi obat lewat urin
𝑑𝐷𝑢
 = ke DO
B e
– ktmid
𝑑𝑡

 Du = Vu*Cu (mg)  volume urin*Konsentrasi urin

𝑑𝐷𝑢 𝐷𝑢
 ⁡= 𝑡𝑎𝑘ℎ𝑖𝑟−𝑡𝑎𝑤𝑎𝑙
𝑑𝑡
𝑡𝑎𝑘ℎ𝑖𝑟+𝑡𝑎𝑤𝑎𝑙
 tmid = 2
𝑑𝐷𝑢
 ln = lnke DO
B – ktmid
𝑑𝑡
 𝑒 lnke
 ke = (/jam)
DO
B⁡

 DO
B = Do (Dosis)
𝑘𝑒
 fe = 𝑘

 ClR = ke*VD (L/jam)

0,693⁡
 t1/2 = (jam)
𝑘

b. Metode ARE
 ln ARE = ln 𝐷𝑢∞ - ktakhir
 Dukum (Du kumulatif) = penjumlahan Du1+2, Du2+3, …
 Dutotal = Total Dukum
 ARE = Dutotal – Dukum perbagian
∞
 𝐷𝑢∞ = 𝑒 ln𝐷𝑢 (mg)
0,693
 t1/2 eliminasi = (jam)
𝑘
𝐷∞
 𝑢
fe = 𝐹𝐷𝑜

3. Oral
𝐹.𝐷𝑜 𝑘𝑎
 Cp = 𝑉 (𝑒 −𝑘𝑡 − 𝑒 −𝑘𝑎𝑡 )
𝐷 ⁡(𝑘𝑎−𝑘)

𝐹𝐷𝑜 𝑘𝑎
 =B=A
𝑉𝑑(𝑘𝑎−𝑘)

 Cp = Be-kt – Ae-kat

 t1 – t4 = fase absorpsi  menentukan ka (metode residual ka>>k)

 Cr = Ae-kat
 lnCr = lnA-kat
 A = elnA
 C’ = hasil ekstrapolasi LR1  diambil dari persamaan Cp = Be-kt
 Cr = C’ – Cp
 ka (/jam)
 𝑘𝑎
ln⁡( )
 𝑘
tmaks = (𝑘𝑎−𝑘) (jam)

 Cpmaks = Be-k tmaks – Ae-ka tmaks (mg/L)

B⁡ A⁡
 AUC0-inf = - 𝑘𝑎 (mg.jam/L)
𝑘
0,693⁡
 t1/2 abs = (jam)
𝑘𝑎

 Fase distribusi
FDo⁡ka FDo
 VD =⁡𝐵⁡(𝑘𝑎−𝑘) = 𝑘AUC0−inf⁡

 t9 – t12 = fase eliminasi  untuk menentukan k

 Cp = Be-kt
 lnCp = lnB-kt
 B = elnB (mg/L)
 k (/jam)
0,693⁡
 t1/2 el = (jam)
𝑘
FDo⁡
 ClT = k*VD = AUC0−inf⁡ (L/jam)