Professional Documents
Culture Documents
Contraception and
Sterilization
Contraception 192
BARRIER METHODS 194
HORMONAL AGENTS 196
INTRAUTERINE DEVICE 200
POSTCOITAL/EMERGENCY CONTRACEPTION 201
Sterilization 201
VASECTOMY 201
BILATERAL TUBAL OCCLUSION 202
OTHER METHODS OF STERILIZATION 204
Abstinence 204
CONTINUOUS ABSTINENCE 204
NATURAL FAMILY PLANNING 204
191
CO N T R AC E PT I O N
DISADVANTAGES AND
CATEGORY AGENTS MECHANISM BEST SUITED FOR CONTRAINDICATIONS
Allergies to materials
Diaphragm may be
associated with more UTIs
Combined Combined oral Inhibits ovulation Iron deficiency anemia Known thrombogenic
hormonal contraceptives Thickens cervical Dysmenorrhea mutations
(estrogen and Contraception mucus to Ovarian cysts Prior thromboembolic
progestin) patch inhibit sperm Endometriosis event
Vaginal ring penetration OCP—take pill every Cerebrovascular or
Alters motility day coronary artery disease
of uterus and Patch—less to Cigarette smoker over age
Contraception and Sterilization
192
T A B L E 1 3 - 1 . Comparison of Contraceptive Agents (continued)
DISADVANTAGES AND
CATEGORY AGENTS MECHANISM BEST SUITED FOR CONTRAINDICATIONS
H IG H-YI E LD FACTS
(subdermal in (progestin) Thins Desires long-term of thrombosis or
arm) endometrium contraception (lasts thromboembolic disorders
Thickens cervical 3 yr) Hepatic tumors (benign
mucous to Iron deficiency anemia or malignant), active liver
inhibit sperm Dysmenorrhea disease
penetration Ovarian cysts Undiagnosed abnormal
Endometriosis vaginal bleeding
Known or suspected
carcinoma of the breast or
personal history of breast
cancer
IUD Levonorgestrel Thickens cervical Desires long-term Current STI or recent PID
IUD mucous reversible contraception Unexplained vaginal
Thins (5 yr) bleeding
endometrium Stable, mutually Malignant gestational
monogamous trophoblastic disease
relationship Untreated cervical or
Menorrhagia endometrial cancer
Dysmenorrhea Current breast cancer
Anatomical abnormalities
distorting the uterine
cavity
Uterine fibroids distorting
endometrial cavity
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T A B L E 1 3 - 1 . Comparison of Contraceptive Agents (continued)
DISADVANTAGES AND
CATEGORY AGENTS MECHANISM BEST SUITED FOR CONTRAINDICATIONS
future
IUD, intrauterine device; PID, pelvic inflammatory disease; STI, sexually transmitted infection; UTI, urinary tract infection.
(Reprinted, with permission, from Toy EC, et al. Case Files: Obstetrics and Gynecology, 3rd ed. New York: McGraw-Hill, 2009: 283.)
Barrier Methods
FEMALE CONDOM
Rarely used because of expense and inconvenience (it must not be re-
moved for 6–8 hr after intercourse).
It offers labial protection, unlike the male condom.
Efficacy: 79%.
MALE CONDOM
TYPES
Latex (most common, inexpensive).
Polyurethane (newest, sensitive, expensive).
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Animal skins (sensitive, least protection against sexually transmitted in-
fections [STIs]).
DIAPHRAGM
A flexible ring with a rubber dome that must be fitted by a gynecologist. It cre-
ates a barrier between the cervix and the lower portion of the vagina. It must
be inserted with spermicide and left in place after intercourse for 6–8 hr. Inconsistent condom use
accounts for most failures.
EFFICACY
H IG H-YI E LD FACTS
80–94%.
COMPLICATIONS
If left in for too long, may result in Staphylococcus aureus infection
(which may cause toxic shock syndrome).
May ↑ risk of urinary tract infection (UTI).
CERVICAL CAP
A smaller version of a diaphragm that fits directly over the cervix. It is more Efficacy rates for
popular in Europe than in the United States.
spermicides are much
SPERMICIDE
Foams, gels, creams placed in vagina up to 30 min before intercourse. Do not
reduce the risk of STIs.
P450 inducers will decrease
TYPES the efficacy of oral
contraceptives (OCPs) (eg,
Nonoxynol-9 and octoxynol-3 are active ingredients of spermicide, which dis-
phenytoin, rifampin,
rupt the sperm cell membrane; effective for only about 1 hr.
griseofulvin,
EFFICACY carbamazepine, alcohol,
barbiturates) due to
74–94%.
increased clearance.
SPONGE
A polyurethane sponge containing nonoxynol-9 that is placed over the cervix.
It can be inserted up to 24 hr before intercourse. Production has been discon-
tinued in the United States.
Hormonal patch may be
EFFICACY
less effective in obese (≥
84%. 200 lbs) women.
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RISK
Toxic shock syndrome.
Hormonal Agents
Types of estrogens:
Estradiol: Reproductive life
A 37-year-old G2P2 woman desires a reversible form of contraception.
Estriol: Pregnancy
Her history reveals that she smokes cigarettes, suffers from migraines with
Estrone: Menopause
auras, has uncontrolled hypertension (HTN), and has a first-degree rela-
tive with a history of breast cancer. She requests combination oral contraceptive
pills (COCs). How do you counsel this patient?
Answer: The patient should not be placed on COCs due to her risk factors for
developing venous thromboembolism and strokes. Contraindications for OCP use
Tension headaches are not include: female smokers > 35 years old, uncontrolled HTN, diabetes with vascular
a contraindication for oral disease, migraines with aura, and benign or malignant liver tumors, liver disease,
contraceptive agents.
H IG H-YI E LD FACTS
MECHANISM OF ACTION
The inactive pills in the COC Estrogen suppresses follicle-stimulating hormone (FSH) and therefore
simulate hormone prevents follicular emergence. Maintains stability of endometrium.
withdrawal of the normal Progesterone prevents luteinizing hormone (LH) surge and therefore
menstrual cycle, which inhibits ovulation.
results in menses. Thickens cervical mucus to pose as a barrier for sperm.
Alters motility of fallopian tube and uterus.
Causes endometrial atrophy.
SIDE EFFECTS
Nausea.
Headache.
COC: Estrogen and Bloating.
progesterone combined.
Main mechanisms: BENEFITS
Prevents ovulation
↓ risk of ovarian cancer by 75%.
Alters uterine and
↓ risk of endometrial cancer by 50%.
fallopian tube motility ↓ bleeding and dysmenorrhea.
Thickens cervical mucus Regulates menses.
to prevent sperm Reduces the risk of pelvic inflammatory disease (PID) (thicker mucus),
penetration fibrocystic breast change, ovarian cysts, ectopic pregnancy, osteoporosis,
Causes endometrial acne, and hirsutism.
atrophy ↓ risk of anemia.
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RISKS
↑ risk of venous thromboembolism/stroke (3/10,000).
↑ risk of myocardial infarction (in smokers > 35 years old).
Depression in some.
Migraines. Always check a β-hCG to
rule out pregnancy before
CONTRAINDICATIONS prescribing the acne
Known thrombogenic mutations. medicine isotretinin (very
Prior thromboembolic events. teratogenic!).
Cerebrovascular or coronary artery disease (current or remote).
Cigarette smoking over age 35.
Uncontrolled HTN.
Diabetic retinopathy, nephropathy, peripheral vascular disease.
Known or suspected breast or endometrial cancer.
Undiagnosed vaginal bleeding.
Migraines with aura. What is the treatment for
Benign or malignant liver tumors, active liver disease, liver failure. idiopathic hirsutism? OCP
H IG H-YI E LD FACTS
Known or suspected pregnancy.
197
INJECTABLE HORMONAL AGENTS
EFFICACY
Side effects of estrogen: 99.7%.
H IG H-YI E LD FACTS
Breast tenderness
Nausea MECHANISM OF ACTION
Headache Sustained high progesterone level to block LH surge (and hence ovulation).
Thicker mucus and endometrial atrophy also contribute. There is no FSH
suppression.
INDICATIONS
Side effects of progestin: Especially suitable for women who either cannot tolerate COCs or who
Depression are unable to take COCs as prescribed.
Acne DMPA can provide noncontraceptive benefits in:
Seizure disorder: ↓ the number of seizure episodes.
Weight gain
Contraception and Sterilization
SIDE EFFECTS
Bleeding irregularity/spotting.
Unknown when menstruation/fertility will resume after treatment cessa-
tion (can remain infertile for up to 9 months).
Why is estrogen a ↑ hair shedding.
procoagulant? Estrogen ↑ Mood changes.
factors VII and X and ↓ ↓ high-density lipoprotein (HDL).
antithrombin III. ↓ libido.
Weight gain.
Osteopenia/osteoporosis. Reverse when stop using DMPA.
CONTRAINDICATIONS
Known/suspected pregnancy.
Undiagnosed vaginal bleeding.
Breast cancer.
Progestin-only pill requires Liver disease.
strict compliance and Osteoporosis/osteopenia.
requires taking the pill at
the same time every day. IMPLANTABLE HORMONAL AGENTS
Etonorgestrel (progestin) containing rod inserted in the subcutaneous tissue
of the arm. It should be replaced every 3 years.
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EFFICACY
99.8%.
MECHANISM OF ACTION
Suppression of LH surge and inhibition of ovulation.
Thickened mucus.
Endometrial atrophy.
INDICATIONS
Contraindication/intolerance to oral contraceptives.
Smokers > 35 years old.
Women with diabetes mellitus, HTN, coronary artery disease (CAD).
SIDE EFFECTS
Irregular bleeding
Acne
H IG H-YI E LD FACTS
↓ libido
Adnexal enlargement
Possible difficult removal
CONTRAINDICATIONS
Thrombophlebitis/embolism
Known/suspected pregnancy
Liver disease/cancer
Breast cancer
Concomitant anticonvulsant therapy
199
Intrauterine Device
Insertion of a T-shaped device into the endometrial cavity with a nylon fila-
ment protruding through the cervix into the vagina to facilitate removal.
H IG H-YI E LD FACTS
EFFICACY
The IUD filament provides 97–99.1%.
access for bacteria to the
upper genital tract, so there MECHANISM OF ACTION
is an ↑ risk for infection. Copper T:
Copper causes a sterile inflammatory reaction, creating a hostile en-
vironment.
Inhibits sperm migration and viability.
Damages ovum, changes ovum transport speed.
Used for 10 yr.
Contraception and Sterilization
COMPLICATIONS
PID.
Uterine perforation.
200
Ectopic pregnancy.
Menorrhagia with Copper T.
IUD expulsion.
Actinomyces infection.
Ectopic pregnancy is a
Postcoital/Emergency Contraception dangerous complication of
IUD use.
A 19-year-old G0P0 woman presents to the office concerned that she may
have an undesired pregnancy after engaging in unprotected sex with her
boyfriend 2 days ago. The patient does not remember the date of her last
menstrual period. What therapy can you offer this patient?
Answer: Emergency contraception is effective when initiated within 72 hr of
intercourse. It consists of high-dose progestin, high-dose OCPs, or insertion of a
Copper T IUD.
Copper and levonorgestrel
H IG H-YI E LD FACTS
IUD reduce the risk of
UP TO 3 DAYS AFTER INTERCOURSE ectopic pregnancy
compared to no
Levonorgestrel (Plan B): One 0.75-mg tablet taken within 72 hr of coitus. A contraceptives, but not as
second 0.75-mg tablet is taken 12 hr after the first dose. Efficacy: 89%.
much as OCPs.
UP TO 5 DAYS AFTER INTERCOURSE
Copper T IUD: Can be left in the uterine cavity and provide contraception
for up to 10 yr. Efficacy: Nearly 100%. What are the two methods
of emergency postcoital
contraception? Up to 3 days
Vasectomy
Excision of a small section of both vas deferens, followed by sealing of
the proximal and distal cut ends (office procedure done under local an-
esthesia). Ejaculation still occurs.
Sperm can still be found proximal to the surgical site, so to ensure ste- Tubal occlusion is twice as
rility one must use contraception for 12 weeks or 20 ejaculations and common as vasectomy.
then have two consecutive negative sperm counts.
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Bilateral Tubal Occlusion
Procedures can be performed (Figure 13-1) either postpartum (during cesar-
ean section or immediately after vaginal delivery) or interval (remote from a
pregnancy). An interval tubal occlusion should be performed in the follicular
Tubal ligation is the most phase of the menstrual cycle in order to avoid the time of ovulation and possi-
frequent indication for ble pregnancy.
laparoscopy in the United
States. LAPAROSCOPIC TUBAL OCCLUSION
Eighty to ninety percent of tubal occlusions are done laparoscopically. All
methods occlude the fallopian tubes bilaterally.
ELECTROCAUTERY
This involves the cauterization of a 3-cm zone of the isthmus. It is the most
Tubal occlusion facts: popular method (very effective but most difficult to reverse).
Electrocautery method is
most popular and most CLIPPING
H IG H-YI E LD FACTS
difficult to reverse.
The Hulka-Clemens clip (also Filshie clip), similar to a staple, is applied at a
Clipping method is most
90-degree angle on the isthmus. It is the most easily reversed method but also
easily reversed but also
has the highest failure rate.
the most likely to fail.
BANDING
A length of isthmus is drawn up into the end of the trocar, and a silicone
band, or Fallope ring, is placed around the base of the drawn-up portion of
fallopian tube.
Contraception and Sterilization
Madlener Kroener
(Reproduced, with permission, from Cunningham G, et al. Williams Obstetrics, 21st ed. New York: McGraw-Hill, 2001: 1556.)
202
HYSTEROSCOPIC OCCLUSION (Essure)
Small polyester/nickel/titanium/steel coil implant is placed in the proxi-
mal fallopian tube.
Minimally invasive.
Two-year data shows 99.8% efficacy. Essure is the most effective
Alternative contraception needed until tubal occlusion proved by hys- method of permanent
terosalpingogram 3 months after implant placed. sterilization available
Mechanism of action: Scarring forms around implant over 3 months
and prevents sperm to enter the fallopian tube.
H IG H-YI E LD FACTS
of isthmus is tied proximally and distally and then excised.
tubes.
Madlener method: Similar to the Pomeroy but without the excision, a
segment of isthmus is lifted and crushed and tied at the base.
Irving method: The isthmus is cut, with the proximal end buried in the
myometrium and the distal end buried in the mesosalpinx.
Kroener method: Resection of the distal ampulla and fimbriae follow-
ing ligation around the proximal ampulla.
Uchida method: Epinephrine is injected beneath the serosa of the isth- Selection of patient for
mus. The mesosalpinx is reflected off the tube, and the proximal end of tubal ligation is important:
the tube is ligated and excised. The distal end is not excised. The meso- Little to no history of
salpinx is reattached to the excised proximal stump, while the long dis- pelvic adhesions
tal end is left to “dangle” outside of the mesosalpinx. Little to no history of
LUTEAL-PHASE PREGNANCY
A luteal-phase pregnancy is a pregnancy diagnosed after tubal sterilization but
conceived before. Occurs around 2–3/1000 sterilizations. It is prevented by ei-
ther performing sensitive pregnancy tests prior to the procedure or performing
the procedure during the follicular phase.
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Other Methods of Sterilization
COLPOTOMY
Utilizes entry through the vaginal wall near the posterior cul-de-sac and oc-
cludes the fallopian tubes by employing methods similar to those performed
in laparoscopy and laparotomy.
HYSTERECTOMY
Removal of the uterus, either vaginally or abdominally; rarely performed for
sterilization purposes. Failure rate is < 1%. Pregnancy after hysterectomy =
ectopic pregnancy = emergency.
A B ST I N E N C E
Continuous Abstinence
H IG H-YI E LD FACTS
Abstaining from vaginal intercourse at any time. It is the only 100% effective
way to prevent pregnancy.
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SYMPTOTHERMAL METHOD
Combination of previous two methods. In addition to taking the temperature
and checking for mucus changes every day, the woman checks for other signs
of ovulation: abdominal pain or cramps, spotting, and changes in the position
and firmness of the cervix. This method requires that you abstain from sex
from the day you first notice signs of fertility until the third day after the eleva-
tion in temperature. This method can be more effective than either of the
other two methods because it uses a variety of signs.
LACTATIONAL AMENORRHEA
The use of breast-feeding to space pregnancies through exclusive breast-
feeding, which means no pacifiers, no bottles, and nursing on demand. This
may be difficult for working mothers, so it may not be as reliable for child
spacing.
ADVANTAGES OF NFP
H IG H-YI E LD FACTS
No side effects, allergies, breakthrough bleeding, bloating, or hormonal
impact on libido.
Low cost.
Reversible.
Improved knowledge and understanding of woman’s fertility and nor-
mal cycle.
Improve communication: The woman should communicate her fertil-
ity status to her partner.
No impact on breast-feeding—no risk to baby.
DISADVANTAGES OF NFP
Abstinence isn’t always easy.
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