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4 - Embryology Lecture 4 (Week 2 of Development A)

This document provides an overview of embryological development during the second week, specifically days 8 and 9. On day 8, the blastocyst is partially embedded in the endometrium and the trophoblast differentiates into the inner cyto and outer syncytiotrophoblast layers. The embryoblast also differentiates into the hypoblast and epiblast layers to form the bilaminar embryonic disc. On day 9, the blastocyst is more deeply embedded, vacuoles appear in the syncytiotrophoblast forming lacunae, and the hypoblast forms the exocoelomic membrane at the abembryonic pole.

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279 views31 pages

4 - Embryology Lecture 4 (Week 2 of Development A)

This document provides an overview of embryological development during the second week, specifically days 8 and 9. On day 8, the blastocyst is partially embedded in the endometrium and the trophoblast differentiates into the inner cyto and outer syncytiotrophoblast layers. The embryoblast also differentiates into the hypoblast and epiblast layers to form the bilaminar embryonic disc. On day 9, the blastocyst is more deeply embedded, vacuoles appear in the syncytiotrophoblast forming lacunae, and the hypoblast forms the exocoelomic membrane at the abembryonic pole.

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Mostafa Mostafa
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Dr.

Eman El Sawaf
Anatomy & Embryology Department
Faculty Of Medicine, Helwan University
Basic Medical Science I
Module

Anatomy

General
Embryology
General Embryology
Objectives
By the end of this lecture student should be able to:
Study the 2nd week of development
(Bilaminar germ disc)
(Day 8 & 9)
Contents

-Day 8 blastocyst
-Day 9 blastocyst
The blastocyst is partially
embedded in the Day 8
endometrial stroma.
2-Endometrial
1- Surface epithelium stroma
(Epithelial cells)

1
2
Day 8

-The blastocyst is
partially embedded in
the endometrial stroma.
Day 8
Trophoblast
Day 8
- In the area over
the embryoblast,
the trophoblast
differentiate into
two layers.
Trophoblast Day 8
Inner layer Outer layer
Cyto Syncytio
trophoblast trophoblast
Mononucleated Multinucleated Syncytio
cells zone without trophoblast
clear cell
boundaries

Cyto
trophoblast
Day 8

Syncytio
trophoblast

Cytotrophoblast
Day 8
Trophoblast Day 8
- The cells in the cytotrophoblast divide and migrate
into the syncytiotrophoblast.

Syncytiotrophoblast

Cytotrophoblast
Embryoblast
Day 8
- Cells of the inner cell
mass or embryoblast
differentiate into two
layers.
Embryoblast Day 8
Hypoblast Epiblast
layer layer
Small High
cuboidal cells columnar
near to the cells near to
blastocyst the amniotic
cavity cavity
The 2 layers form a flat disc.

Epiblast

Hypoblast
Blastocyst cavity
Day 8

Epiblast Hypoblast Blastocyst cavity


Day 8 Epiblast

Hypoblast

Bilaminar embryonic disc


Embryoblast Day 8
-Small cavity appears
within the epiblast.
-This cavity enlarges
to become the amniotic
cavity.
-The epiblast cells near
to the cytotrophoblast
are called amnioblasts.
Amnioblast

Amniotic cavity

Blastocyst cavity
Epiblast Hypoblast
Day 8

Amnioblast

Amniotic
cavity

Epiblast Hypoblast Blastocyst cavity


Day 9

The penetration
defect in the
Blastocyst is surface epithelium
deeply embedded is closed by a fibrin
in the endometrium. coagulum.
Blastocyst is
deeply embedded Day 9
in the endometrium. Endometrium
Endometrium

The penetration
defect in the surface
epithelium is closed
by a fibrin coagulum.
Day 9
Trophoblast Day 9

Vacuoles
appear in the
syncytiotrophoblas
(Syncytium)
Trophoblast Day 9
When the vacuoles
fuse they form

Large lacunae

Lacunar stage
Day 9
At the abembryonic pole Day 9

The hypoblast form


a thin membrane,
the exocoelomic
(Heuser) membrane
(flattened cells)

Hypoblast

Abembryonic pole
At the abembryonic pole Day 9
The hypoblast form
a thin membrane,
the exocoelomic
(Heuser) membrane
(flattened cells)

Exocoelomic
membrane

Exocoelomic cavity
(primitive yolk sac)
Hypoblast
Day 9

Exocoelomic
membrane

Exocoelomic cavity Hypoblast


(primitive yolk sac)
Reference
-Langman’s Medical Embryology
13th Edition, T.W. Sadler.
Images:
- Langman’s Medical Embryology
- [Link]
- 8 weeks pregnant: fetal development Approved by the BabyCentre Medical
Advisory Board
-[Link]
-File:Early development stages with [Link]
- From Wikimedia Commons, the free media repository
-BGDA Practical 3 - Early Cell Division
-File:Human embryo day 5 [Link]
-3RD WEEK OF PREGNANCY
-C [Link]
- ANIMATION: MANUEL HERNANDO
-General Embryology - Detailed Animation On Second Week Of Development
Thank You

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