all An ounce of prevention is worth a pound of cure, so they say.

Scientists have now

demonstrated a new potential cancer vaccine that involves injections of dormant tumor
cells to stimulate the immune system and help prevent the onset of cancer.
A cancer vaccine woThe film has been produced by Morgan Neville, Meghan Walsh, Chris
Shellen and is helmed by Jeff Malmberg. Neville and Malmberg previously teamed up for
the Academy Award-winning documentary Won't You Be My Neighbour? Featured in the
documentary are a number of important figures at Disney, including animation artist Floyd
Norman and director of the Walt Disney Archives, Rebecca Cline. The new Walt Disney
Animation Studios hand-drawn animated short Mickey in a Minute is a part of the feature,
which will also documents its animation process by Disney animators Eric Goldberg, Mark
Henn and Randy Haycock.
“Ninety-four years ago, Walt Disney created a mouse that would become one of the world’s
most beloved characters,” said Marjon Javadi, vice president of Disney Original
Documentary and Docuseries for Disney Branded Television/Disney Original Documentary.
“We are excited for the world to see Mickey Mouse in a way they’ve never seen him before.
Our award-winning team of filmmakers captures Mickey’s journey through the years and
reminds us why he has had such an impact on us.”
You can see the full trailer for Mickey: The Story of a Mouse , as well as the synopsis
below. The documentary premieres on Disney+ on November 18. Oh boy!
“One of the world’s most beloved icons, Mickey Mouse is recognized as a symbol of joy
and childhood innocence in virtually every corner of the globe. It has been a remarkable
journey for a character dreamed up at a low point in the career of Walt Disney, an
ambitious young artist who moved to Hollywood from Kansas City, Missouri. Disney’s
groundbreaking short “Steamboat Willie,” the first synchronous-sound animated film, turned
Mickey into an overnight sensation and made shorts featuring the plucky mouse a staple of
moviegoing during the height of the medium’s popularity. In the decades that followed,
Mickey was transformed into strikingly different versions of himself, reflecting both the
trajectory of his creator’s stunning rags-to-riches care
uld be something of a Holy Grail to modern medicine, and unsurprisingly much work is
directed towards this goal. Some techniques would be therapeutic, fighting cancer that’s
already present in a patient, while others could be preventative, designed to reduce the risk
of cancer forming in the first place. Either way, these vaccines would work by stimulating
the immune system to recognize cancer.
Now, scientists at the Institute for Research in Biomedicine (IRB) Barcelona have
developed a new type of cancer vaccine. Previous versions have been designed to
stimulate the immune response by administering dead tumor cells, but in the new study the
team found more success using cancer cells in a dormant state known as senescence.
As cells age and accumulate DNA damage, they eventually reach a point where they stop
dividing, but instead of dying off they lie dormant. These so-called senescent (or "zombie")
cells are implicated in many of the symptoms of aging, but they appear to be a protective
mechanism against cancer, which is essentially uncontrolled cell division.
So for the new study, the IRB team investigated whether senescent tumor cells could be
used instead of dead ones to stimulate an immune response. After all, they still have the
same markers that immune cells are on the lookout for, but without the risk of them growing
and dividing.
The researchers vaccinated healthy mice with senescent tumor cells, then one week later
injected them with live melanoma or pancreatic cancer cells. And sure enough, the number
of mice that went on to develop tumors was significantly reduced in the group that received
senescent tumor cells, compared to controls inoculated with cancer cells in the process of
dying.
The team also administered the senescent cell vaccines to mice that already had
developed tumors, and found some improvements there too, albeit not to the same extent
as the prophylactic treatment.
Closer examination revealed that the senescent cells were highly efficient in stimulating
important immune cells – dendritic cells and CD8 T cells – against the cancer.
“Our study concludes that the induction of senescence in tumor cells improves the
recognition of these