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Chapter 2 (Part 1)
Diagrams of Neuron
Neurons
Their Basic Structure and Function
• Neurons: Nerve Cells specialized for communicating information, the basic
building blocks of the nervous system.
• They vary in appearance but always have 3 Basic Parts: Cell Body, an
Axon, and
one or more Dendrite.
• Dendrites: The parts of a Neuron that conduct action potentials
(information/
signals) toward the cell body.
• Soma: The cell body of a neuron contains the nucleus and other structures
common to living cells. These structures support the chemical processing of
the
neuron: the most important off which is the production of neurotransmitters.
Neuron: Their Basic Structure and Function
Continued…
• Axon: The part of the Neuron that conducts the action potential
(information/
signals) away from the cell body
• FUN FACT: There are more than 85 billion neurons in the human brain!
• Myelin Sheath: a sleeve that wrapped around each neuron. Its a protective
layer of
fat (lipids) and protein that coats the main body section of a neuron called the
Axon.
• Function of a Myelin Sheath: Insulates Axons allowing for rapid action
potential
conduction. Separates axons from surrounding extracellular components.
• Damage to the myelin sheath surrounding axons can seriously affect
synaptic
transmission. An Example: MS ( Multiple Sclerosis) Jack Osborne, Selma
Blair.
Neurons: Their Basic Structure and Function
Continued…
• Glial Cells: Cells in the nervous system that surround, support, and protect
neurons
• They outnumber neurons 10 to 1.
• Functions or Glial Cells: They form the myelin sheath around axons and
perform
chores such as cleaning up cellular debris, form a barrier that prevents certain
substances in the blood stream from reaching the brain.
• Axon Terminals: Structures at the end of axons that contain transmitter
substance.
• Function of Axon Terminals: The terminals release transmitter substances
into gaps
called the synaptic cleft between the terminals and the dendrites of the next
neuron.
Neurons: Their Basic Structure And Function
Continued…
• Axon Hillock: a specialized part of the soma of a neuron that connects to
the axon.
• Synapse: A region where the axon of one neuron closely approaches
other neurons or the cell membrane of other types of cells such as muscle
cells.
• Synaptic Transmission: The biological process by which a neuron
communicates with a target neuron across a synapse.
Video: communication within a Neuron
• https://www.youtube.com/watch?v=6qS83wD29PY
Neurons: Their Basic Structure And Function
Continued…
• Nodes of Ranvier: Periodic Gap in the myelin sheath on the axon of certain
neurons that serves to help the rapid conduction of nerve impulses
• Graded Potential: signals which happen along dendrites and basically
travel a small distance
• Synaptic Vesicles: Structures in the axon terminals that contain various
neurotransmitters.
• Neurotransmitters: Chemicals released by neurons that carry information
across synapses.
Neurons: Their Basic Structure And Function
Continued…
• Excitatory Neurons: they release neurotransmitters to make the post
synaptic neuron generate an action potential.
• Inhibitory Neurons: they release neurotransmitters to make post synaptic
neuron less likely to generate an action potential.
• Reuptake: the reabsorption by a neuron of a neurotransmitter following
the transmission of a nerve impulse across a synapse.
• Diffusion: The neurotransmitter drifts away, out of the synaptic cleft where
it can no longer act on a receptor.
Video: Communication between Neurons:
Synaptic Transmission
• https://www.youtube.com/watch?v=WhowH0kb7n0
Neurotransmitters
Chemical Keys to the Nervous System
• There are many different types of Neurotransmitters other than Excitatory
and Inhibitory
• There are chemical substances such as certain drugs that can mimic the
effects of neurotransmitters
• There are special receptor sites for drugs such as morphine and other
opiates because they closely resemble the function of endorphins.
• Agonist: A chemical substance that mimics the action of neurotransmitter
at a receptor site.
Neurotransmitters
Chemical Keys to the Nervous System (Continued…)
• Antagonist: A chemical substance that inhibits the effect normally
produced by a neurotransmitter at a receptor site.
• Many Painkillers (also called analgesic) occupy receptor sites normally
stimulated by endorphins hence blocking pain and producing a
temporary high.
• Opium, heroin, and crack cocaine also occupy these sites and produce
more intensely pleasurable sensations than endorphins… the reason why
we get addicted to them.
Neurotransmitters
Amino Acids
• Glutamate: This is the most common excitatory neurotransmitter of your
nervous
system. It’s the most abundant neurotransmitter in your brain. It plays a key
role in
cognitive functions like thinking, learning, and memory. Imbalances in this
are
associated with Alzheimers, dementia, Parkinson’s disease, and seizures.
• GABA (gamma-amino-butyric acid): the most common inhibitory
neurotransmitter
of your nervous system, particularly the brain. It regulates brain activity to
prevent
problems in the areas of anxiety, irritability, concentration, sleep, seizures,
and
depression.
• Glycine: The most common inhibitory neurotransmitter in your spinal cord.
Glycine
is involved in controlling hearing processing, pain transmission, and
metabolism
Neurotransmitters
Monoamines
• Serotonin: an inhibitory neurotransmitter that helps regulate ,mood, sleep
patterns, sexuality, anxiety, appetite, and pain. Diseases associated with
serotonin imbalances include seasonal depression, anxiety, depression,
fibromyalgia, and chronic pain. Medications that regulate serotonin and
treat these disorders include selective serotonin reuptake inhibitors
(SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)
• Histamine: Regulates body functions including wakefulness, feeding,
behavior, and motivation. Histamine plays a role in asthma,
bronchospasm, mucosal edema and multiple sclerosis.
Neurotransmitters
Monoamines (Continued…)
• Dopamine: plays a role in your body’s “reward system”, which includes
feeling pleasure,
achieving heightened arousal, and learning. Dopamine also helps with focus,
concentration, memory, sleep, mood, and motivation. Diseases associated
with
dysfunctions of the dopamine system include, Parkinson’s disease,
schizophrenia,
bipolar diseases, restless leg syndrome, (ADHD). Drugs such as cocaine and
methamphetamines act directly on the dopamine system.
• Norepinephrine: increases blood pressure and heart rate. It is most widely
known for its
effects on alertness, arousal, decision making, attention, and focus. Many
medications
(stimulants and depression medications) aim to increase norepinephrine
levels to
improve focus and concentration to treat ADHD or to modulate
norepinephrine to
improve depression symptoms. It is a metabolite of dopamine that primarily
acts on the
adrenorecpetors in the blood vessels.
Neurotransmitters
Monoamines (Continued..)
• Epinephrine (Adrenaline): and norepinephrine are responsible for your
body’s flight or fight response to fear and stress. They stimulate your
body’s response by increasing your heart rate (Heart), breathing (Lungs),
blood pressure (Blood Vessels), blood sugar, and blood flow to your
muscles, as well as heighten attention and focus to allow you to act or
react to different stressors. Too much of this can lead to high blood
pressure, diabetes, heart diseases, and other health problems. As a drug,
it is used to treat anaphylaxis, asthma attacks , cardiac arrest and severe
infections.
Neurotranmitters
Peptide
• Peptides are polymers or chains of amino acids.
• Endorphins: The Body’s natural pain reliever. They play a role in our
perception of pain. Release of endorphins reduces pain, as well as causes
“ feel good” feelings. Low levels of endorphins may play a role in
fibromyalgia and some types of headaches.
Neurotransmitter
Acetylcholine
• This is an excitatory neurotransmitter that does a number of functions in
our Central Nervous Systems (CNS- brain and spine) and in our Peripheral
Nervous System ( nerves branching from the CNS). They are released by
most neurons in your autonomic nervous system regulating heart rate,
blood pressure, and gut mobility. They play a role in muscle contractions,
memory, motivation, sexual desire, sleep, and learning. Imbalances in
levels of this are linked to health issues such as Alzheimer’s disease,
seizures and muscle spasms.
The Nervous System
Basic Structure and Function
• It is the structure that neurons along with other types of cells combine to
erect.
• The complex network of neurons that regulates bodily processes and is
ultimately responsible for all aspects of conscious experience
• Components of the Nervous System: Central Nervous System and
Peripheral Nervous System.
Central Nervous System
(CNS)
• Consists of the Brain and Spine
• Functions of the spinal cord: 1) Carries sensory information via afferent
(sensory) nerve fibers from receptors throughout the body to the brain
and conducts information via efferent (motor) nerve fibers from the brain
to muscles and glands. 2) Plays a key role in various reflexes.
• Afferent Nerve Fibers: Nerve fibres in the spinal cord that carry
information from receptors through out the body toward the brain.
• Efferent Nerve Fibers: Nerve fibers in the spinal cord that carry
information from the brain to muscles and glands through out the body.
Peripheral Nervous System
(PNS)
• Consists primarily of nerves, bundles of axons from many neurons, which
connect the central nervous system with sense organs and with muscles
and glands throughout the body.
• Most of these nerves are attached to the spinal cord which serves the
body from neck down.
• Cranial nerves extend from the brain and carry information from receptors
from sensory organs such as the eyes and the ears and also carry
information from the CNS to muscles in the head and neck.
• It has two subdivisions: Somatic and Autonomic nervous system.
Peripheral Nervous System
(PNS Continued…)
• Somatic Nervous System: The portion of the peripheral nervous system
that connects the brain and spinal chord to voluntary muscles. Example:
when you are ordering a pizza or watching Netflix your Somatic Nervous
System is involved
• Autonomic Nervous System: The part of the peripheral nervous system
that connects internal organs, glands and involuntary muscles to the
CNS. Example: the muscles in our digestive system.
• Autonomic System has two parts, Sympathetic Nervous System and
Parasympathetic Nervous System.
Peripheral Nervous System
PNS ( Continued…)
• Sympathetic Nervous System: The portion of autonomic nervous system
that readies the body from expenditure of energy. Example: working out,
Fight or flight
• Parasympathetic Nervous System: The Portion of the autonomic nervous
system that readies the body from restoration of energy: Example:
Digestion.
The Endocrine System Diagram
glands that secrete hormones directly into the blood stream. These hormones
exert profound effects on a wide range of processes related to basic bodily
functions.
influencing neural activity. They are released into the circulatory system
rather
than the synapses hence they exert their effects more slowly, at a greater
(Continued…)
(Continued…)
• Adrenal Glands: Glands that release hormones to help the body handle
emergencies. For example: increasing the heart rate, blood pressure, and
The Brain
A Marvelous Organ
motivation and emotion, and 3) portions concerned with our higher mental
processes
The Brain
The Brain Stem: Survival Basics
The Brain
The Brain Stem and Cerebellum
• The Brain Stem holds structures responsible for regulating bodily processes
we share
with many life forms on earth ( Survival Basics).
• Medulla: The bottom part of the brainstem concerned with the regulation of
vital
bodily functions such as breathing, heart rhythms, blood pressure and
swallowing
• Pons: The middle portion of the brainstem which coordinates facial
movements,
hearing, and balance.
• Midbrain: the top part of the brainstem which is crucial for regulating eye
movements.
• Reticular Activating System (RAS): a network of neurons which controls
sleep and
wake cycles and helps you stay alert and attentive to your surroundings.
• Cerebellum: It is primarily concerned with the regulation of motor
activities, serving to
orchestrate muscular activities so they occur in a synchronized fashion. It can
also play
a role in certain cognitive processes, such as learning.
Motivation and Emotion
Limbic System
• Hypothalamus: Acts as your body’s smart control coordinating center. The
main function of the hypothalamus is to keep your body in a stable state or
internal balance (homeostasis). It also manages your body temperature,
blood pressure, hunger and thirst, sense of fullness when eating, mood,
sex drive, and sleep. It serves as the main link between the endocrine
system and the nervous system.
• Thalamus: It is your body’s information relay station. All information from
your body’s senses (Except Smell) and movements must go through a
preliminary analysis by the thalamus before being sent to other parts of
the brain for further interpretation.
Motivation and Emotion
Limbic System
• Amygdala: Plays a key role in how we assess and
respond to environmental threats and challenges by
evaluating the emotional importance of sensory
information and prompting an appropriate
response. Main function is to regulate emotions
such as fear and aggression. It closely works with
the hippocampus by tying emotion and memory
together.
• Hippocampus: It processes and retrieves
memories. It is also where short term memory is
turned into longterm memory and then stored
elsewhere in the brain. This is also one of the few
places in the brain where new nerve cells are
generated.
The Core Complex of Thought
Cerebral Cortex
• Cerebral Cortex: the part of the brain that is responsible for our ability to
reason, plan,
remember, and imagine.
• The Cortex contains many cell bodies that gives it this brownish-gray color
and it is
referred to as Gray Matter.
• Beneath the cortex are myelin sheathed axons that connect neurons of the
axon to the
other parts of the brain. The large concentration of myelin sheaths gives this
tissue an
opaque appearance which we refer to as White Matter.
• Cortex is divided into two halves called the Cerebral Hemispheres where
each
hemisphere is specialized in the functions they perform.
• Each hemisphere is divided into 4 regions or lobes: Frontal, Parietal,
Occipital, and
Temporal lobes.
Four Lobes
Location and Function
• Frontal Lobe: The portion of the brain
that is concerned with thinking, speaking,
memory, and movement.
• Parietal Lobe: The portion of the brain
that is concerned with language and
touch,
• Occipital Lobe: The portion of the brain
concerned with vision and color
perception.
• Temporal Lobe: The portion of the brain
that is concerned with hearing, learning,
and feelings.
Food for Thought
• Suppose that research clearly identified certain parts of the brain that,
when they malfunction, cause people to engage in violence. Would it be
ethical to perform operations on these persons to repair these
malfunctioning areas?
Divided Brains
Two minds in One body
• The right and left hemispheres of the brain show a considerable degree of
Lateralization of Function meaning each hemisphere specializes in
performing different tasks. The left is the Verbal hemisphere and the right
specializes in Motor movements and in comprehension and
communicating in movements.
• Corpus Callosum: A band of nerve fibers connecting the two
hemispsheres of the brain.