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  • Autonomic Nervous System

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    Uzair Ahmad
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    The document discusses the effects of cholinergic agonists on the autonomic nervous system, noting that they decrease heart rate and blood pressure while increasing motility and secretions in the gastrointestinal tract and urination. Cholinergic agonists are classified as either direct-acting muscarinic agonists or indirect-acting nicotinic agonists, and several direct-acting muscarinic agonists are listed along with their kinetic properties, sites of action, uses, and toxicities.

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    AUTONOMIC NERVOUS SYSTEM

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    The document discusses the effects of cholinergic agonists on the autonomic nervous system, noting that they decrease heart rate and blood pressure while increasing motility and secretions in the gastrointestinal tract and urination. Cholinergic agonists are classified as either direct-acting muscarinic agonists or indirect-acting nicotinic agonists, and several direct-acting muscarinic agonists are listed along with their kinetic properties, sites of action, uses, and toxicities.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    14 views4 pages

    Autonomic Nervous System

    Uploaded by

    Uzair Ahmad
    The document discusses the effects of cholinergic agonists on the autonomic nervous system, noting that they decrease heart rate and blood pressure while increasing motility and secretions in the gastrointestinal tract and urination. Cholinergic agonists are classified as either direct-acting muscarinic agonists or indirect-acting nicotinic agonists, and several direct-acting muscarinic agonists are listed along with their kinetic properties, sites of action, uses, and toxicities.

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    © All Rights Reserved
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    of 4

    AUTONOMIC NERVOUS

    SYSTEM
    [Document subtitle]
    EFFECTS OF CHOLINERGIC AGONIST

    CVS

     Dec HR

     Dec CO

     Vasodil

     Dec BP

    GIT: Inc motility and secretions

    GENITOURINARY: Inc urination

    PULMONARY: Inc sec of bronchioles

    EYE: Miosis

    GLANDS: Inc secretions


    CLASSIFICATION
    DIRECT ACTING INDIRECT ACTING

    MUSCURANIC AGONIST NICOTINIC AGONIST


    MUSCURANIC AGONISTS

    DIRECT ACTING
    NAME KINETIC ACTION USES TOXICITY
    ACETYLCHOLIN Prodrug All
    E Acts on both
    Met by acy
    esterase

    BETHANECHOL Poor lipid sol On bladder Atonic bladder All eff opp
    Oral and git Neurogenic
    X BBB blad
    Dur of act: 1h Megacolon
    CARBACHOL Inc dur of On CVS ( rel Dec IOP
    action of epi) Glaucoma
    On Eye and
    GIT
    PILOCARPINE Ter amine On eye Sjogren
    Cross CNS syndrome
    Treats
    glaucoma

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