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GASTRO-INTESTINAL
What are the drugs indicated here?
SLIDESMANIA

Stomach Small intestine Oral Cavity Pancreas

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GASTROINTESTINAL ALIMENTARY CANAL

TRACT
SLIDESMANIA
SLIDESMANIA
 EMOLLIENT: STOOL SOFTENERS
drug class
SLIDESMANIA
SLIDESMANIA
SLIDESMANIA
SLIDESMANIA
PEPTIC
ULCER
SLIDESMANIA.
 PEPTIC
ULCER
DISEASE
SLIDESMANIA.
 PREDISPOSING FACTORS FOR
PEPTIC ULCER DISEASE
 Mechanical disturbances

 Genetic influences

 Environmental influences

 Helicobacter pylori
SLIDESMANIA.

 Drugs
SLIDESMANIA.
1.
1. TRANQUILIZERS
TRANQUILIZERS
2. ANTICHOLINERGICS
3. ANTACIDS
4. H2 BLOCKERS

ANTIULCER
DRUGS
5. PROTON PUMP INHIBITORS

6. PEPSIN INHIBITOR SUCRALFATE

SLIDESMANIA.

7. PROSTAGLANDIN E1
 DRUG NAME LIBRAXON Chlordiazepoxide-
TRANQUILIZERS Clidinium

CLASS TRANQUILIZERS

Minimal effect in preventing and treating ulcers;

MECHANISM OF blocks the acid secretion of the gastrointestinal tract and inhibits the action of
however,
ACTION
they reduce vagal
nerves that stimulation
are very active in certain diseases.  and
decrease anxiety.
ADVERSE EFFECTS Edema, ataxia, confusion. And agranulocytosis
SLIDESMANIA.
 DRUG Propantheline
ANTICHOLINE DRUG
NAME
NAME
Glycopyrrolate  Cuvposa,
glycopyrronium, and

RGICS
Robinul
CLASS Anticholinergics
CLASS Anticholinergics
Decreases acetylcholine by
blocking the cholinergic receptors. MECHANIS .decreases the motion of muscles in the
MECHANIS
M OF stomach
inhibits and
the production
action ofof stomach acid.
acetylcholine on

M OF structures innervated by postganglionic

ACTION
cholinergic nerves and on smooth muscles that
ACTION
SIDE Headache, dizziness, butblurred
respond to acetylcholine vision,
lack cholinergic
EFFECTS weakness,
innervation. dry mouth, nausea and
AND
SIDE vomiting,
Headache,urinary retention
,dyspnea, sinusitis, dry mouth,
ADVERSE
SLIDESMANIA.

EFFECTS infection, nausea vomiting

REACTIONS
AND