COVID-19

COVID.gov NIH Research information | Español NIH staff guidance (NIH Only)

NIH RESEARCH MATTERS

December 13, 2016

Recalling temporary memories

At a Glance
Researchers restored recently “set aside” memories by magnetically stimulating the unique patterns of brain activity that
were originally provoked.
The study provides insight into how the brain may temporarily store information.
Working memory lets you temporarily hold information in your mind so you can quickly act on it. m-imagephotography/iStock/Thinkstock

Sometimes you need to remember information for only a short period of time―like when dialing a phone number. This type of memory is
called working memory. It lets your brain hold onto information as you’re using it, then discard it if it’s no longer needed or store it in your
long-term memory.
To investigate the underlying neural mechanisms for working memory, a team led by Dr. Bradley Postle at the University of Wisconsin-
Madison carried out a series of brain imaging and stimulation studies in student volunteers. The research was funded in part by NIH’s
National Institute of Mental Health (NIMH). Results were published in Science on December 2, 2016.

The researchers measured the brain activity of the young adults by using fMRI or electroencephalography (EEG) while they performed
working memory tasks. The volunteers were shown 2 items that they might need to recall later on. These included either a face, a word, or
the direction that dots moved on a screen. The scientists determined the pattern of the volunteers’ brain activity as they focused on each
item. Using this information, the scientists could “see” when the subjects had the image in their minds.

The participants were then asked to mentally focus on only one of the images to compare and match it with new images. As the subjects
focused on the one image, its unique pattern of activity continued to exist in the brain scans. The brain activity patterns representing the
other, temporarily unneeded, item disappeared―similar to what's observed when people are asked to forget information.

Using a technique called transcranial magnetic stimulation, or TMS, the researchers attempted to stimulate the memory of the temporarily
unneeded item. They delivered magnetic stimulation to the brain regions that the item had uniquely activated when subjects had been
thinking of it. This stimulation brought the subjects’ attention back to the unneeded item and interfered with their performance on the
recognition test for the item they were asked to focus on.

Most models of the brain assume that brain activity patterns need to continue in order to hold something in your working memory, Postle
explains. “But we’re watching people remember things almost perfectly without showing any of the [continuous] activity that would come
with [brain cells] firing. The fact that you’re able to bring it back at all in this example proves it’s not gone. It’s just that we can't see evidence
for its active retention in the brain,” he says.

More research is needed to investigate how memories can be stored and retrieved in the absence of sustained brain activity patterns and
how the brain determines what to discard.

—by Tianna Hicklin, Ph.D.

Related Links

Storing Memories of Recent Events (https://www.nih.gov/news-events/nih-research-matters/storing-memories-recent-events)

Brain Wave Synchronization Key to Working Visual Memory (https://www.nih.gov/news-events/nih-research-matters/brain-wave-

synchronization-key-working-visual-memory)

Mental Replay in Learning and Memory (https://www.nih.gov/news-events/nih-research-matters/mental-replay-learning-memory)

Monitoring the Brain’s Memory-Making Cells (https://www.nih.gov/news-events/nih-research-matters/monitoring-brains-memory-

making-cells)

Sleep On It: How Snoozing Strengthens Memories (https://newsinhealth.nih.gov/issue/apr2013/feature2)

Brain Basics (http://www.nimh.nih.gov/health/educational-resources/brain-basics/brain-basics.shtml)

References: Reactivation of latent working memories with transcranial magnetic stimulation. Rose NS, LaRocque JJ, Riggall AC, Gosseries O, Starrett MJ,
Meyering EE, Postle BR. Science. 2016 Dec 2;354(6316):1136-1139. PMID: 27934762.

Funding: NIH’s National Institute of Mental Health (NIMH)

In this Edition
Recalling temporary memories
Social status alters immune response in monkeys

Novel insecticide blocks mosquitoes’ ability to urinate

Search NIH Research Matters

Connect with Us
Subscribe to get NIH Research Matters by email

RSS Feed

Facebook

Email us

Mailing Address:

NIH Research Matters

Bldg. 31, Rm. 5B52, MSC 2094

Bethesda, MD 20892-2094

Popular Stories
Alzheimer’s tied to cholesterol, abnormal nerve insulation

COVID-19 disrupts gut microbiome

Long COVID symptoms linked to inflammation

Immune cells control waste clearance in the brain

How timing of eating affects metabolism and weight gain

About NIH Research Matters

Editor: Harrison Wein, Ph.D.

Assistant Editor: Vicki Contie

NIH Research Matters is a weekly update of NIH research highlights reviewed by NIH’s experts. It's published by the Office of
Communications and Public Liaison in the NIH Office of the Director.

ISSN 2375-9593
NIH…Turning Discovery Into Health®

National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892

U.S. Department of Health and Human Services