POOL TO UHS MCQS BOOK

Lipid Metabolism MCQs

Past UHS MCQs
(Annual Wise 2012 to 2022)
1. The rate limiting step in cholestrol biosynthesis is
(UHS ANNUAL 2012)
A- Squalene synthetase
B- Mevalonate kinase
C- HMG Co.A synthetase
D- HMG Co A reductase
E- Thiolase
Correct Answer: D
2. Carnitine is synthesised from (UHS ANNUAL 2012)
A- Lysine
B- Choline
C- Serine
D- Arginine
E- Threonine
Correct Answer: A
3. Triacyl glycerol present in VLDL is hydrolysed by (UHS ANNUAL 2012)
A- lipoprotein lipase
B- Intestinal lipase
C- Pancreatic lipase
D- Hormone sensitive lipase
E- None of the above
Correct Answer: A
4. The free fatty acids in blood are (UHS ANNUAL 2012)
A- Stored in fat deposits
B- Mainly bound to beta lipoproteins
C- Mainly bound to serum lipoprotiens
D- Mainly bound to serum albumin
E- Mainly bound to.serum globulin
Correct Answer: D
5. Respiratory distress syndrome in premature newborns is caused by
defeciency in the lungs of a (UHS ANNUAL 2012)
A- Sphingomyelin
B- Ganglioside
C- Triacylgycerol
D- Phosphatidylcholine
E-Prostaglandin
Correct Answer: D
6. A woman was told by her physician to go on a low -fat diet .She
decided to continue to.consume the same number of calories by
increasing her carbohydrate intake ,while decreasing her fat
intake .Which of the following blood lipoproteins would be decreaed as
a consequence of this diet?(UHS ANNUAL 2013)
A- VLDL
B- IDL
C- LDL
D- Chylomicrons
E- All of the above
Correct Answer: D
7. A person with Type I diabates mellitus failed to take insulin regularly
and was found to hav high VLDL levels.As a consequence ,which of the
following compounds in the blood would be elevated? (UHS ANNUAL
2013)

A- Triacylglycerol
B- Cholestrol
C- Lipoprotein lipase
D- Both a and b
E- None of the above
Correct Answer: D
8. Approximately how many net moles of ATP are generated when one
mole of beta hydroxybutyrate is oxidized to carbondioxide and water in
skeletal muscle (UHS ANNUAL 2013)
A- 23
B- 24
C- 25
D- 26
E- 27
Correct Answer: D
9. All of the following tissues are capable of using ketone bodies,except
(UHS ANNUAL 2013)
A- Brain
B- Red blood cells
C- Renal cortex
D- Skeletal muscle
E- Cardiac muscle
Correct Answer: B
10.The major source of cholestrol in arterial smooth muscle cells is from
(UHS ANNUAL 2014)
A- IDL
B- HDL
C- LDL
D- Chylomicrons
E- All of the above
Correct Answer: C
11.Ketone bodies are synthesised from fatty acid oxidation products by
which of the following organs (UHS ANNUAL 2014)
A- Skeletal muscles
B- Kidney
C- Brain
D- Liver
E- Erythrocytes
Correct Answer: D
12.A pathway that requires NADPH as a cofactor is (UHS ANNUAL 2014)
A- Fatty acid oxidation
B- Glycogenesis
C- Gluconeogenesis
D- Extramitochondrial Denovo Fatty acid synthesis
E- Ketone body formation
Correct Answer: D
13.Which one of the following sequence places the lipoproteins in the
order of most dense to least dense (UHS ANNUAL 2014)
A- HDL/VLDL/Chylomicrons /LDL
B- HDL/LDL/VLDL/chylomicrons
C- LDL/chylomicrons /HDL/VLDL
D- VLDL/chylomicrons /LDL/HDL
E- LDL/Chylomicrons /VLDL /HDL
Correct Answer: B
14.The net yield of high -energy bonds from the complete oxidation of
acetoacetate in the brain is (UHS ANNUAL 2015)
A- 11
B- 12
C- 23
D- 24
E- 25
Correct Answer: C
15.In the uptake of fatty acids into mitochondria ,there is involvement of
(UHS ANNUAL 2015)
A- Carnitine
B- Lipoic acid
C- Acetyl.co A
D- Cholestrol
E- All of the above
Correct Answer: A
16.The key regulatory enzyme of fatty acid synthesis is(UHS ANNUAL
2015)
A- ATP citrate lyase
B- Acetyl co A carboxylase
C- Citrate cleavage enzyme
D- Malonyl transacylase
E- None of the above
Correct Answer: B
17.A teenager ,concerned about his weight,attempts to maintain a fat
free diet for a period of several weeks .If his ability to synthesize various
lipids were examined ,he would be found to be most deficient in his
ability to synthesize (UHS ANNUAL 2015)
A- Cholestrol
B- Glycolipids
C- Phospholipids
D- Prostaglandins
E- Triacylglycerol
Correct Answer: D
18. A 4 month old child is being evaluated for fasting
hypoglycemia .Laboratory tests at admission reveals low level of ketone
bodies ,free carnitine and acyl carnitine in the blood.Free fatty acid
levels in the blood were elevated.Defeciency of which of the following
would best explain these findings (UHS ANNUAL 2016)
A- Adipose triglyceride lipase
B- Carnitine transporter
C- Carnitine palmitoyltransferase
D- Long chain fatty acid dehydrogenase
E- All of the above
Correct Answer: B
19.Phospholipids that contain glycerol are called (UHS ANNUAL 2016)
A- Glycerophospholipids
B- Phosphoglycerides
C- Both a and b
D- Sphingophospholipids
E- Sphingomylin
Correct Answer: C
20.Component of phospholipid that is involved in syphilis caused by
treponema pallidum (UHS ANNUAL 2016)
A- Plasmogens
B- Cardiolipin
C- Sphingomyelin
D- Platelet activating factor
E- Cardiac Glycosidase
Correct Answer: B
21.Which type of pneumocytes are involved in lung surfactant (UHS
ANNUAL 2016)
A- Type 1
B- Type 2
C- Type 3
D- Type 4
E- All of above
Correct Answer: B
22.Ceramides play an important role in (UHS ANNUAL 2016)
A- Maintaing skin waters permeability barrier
B- Brain water permeability barrier
C- Electrolytes homeostasis
D- All of the above
E- None of above
Correct Answer: A
23.Sulfatides are found predominantly in (UHS ANNUAL 2016)
A- Liver
B- Kidney
C- Brain
D- Muscle
E- Both b and c
Correct Answer: E
24.Fabry s disease is a genetic disorder caused by (UHS ANNUAL 2017)
A- X linked
B- Y linked
C- Autosomal
D- X & Y Linked Both
E- None of above
Correct Answer: A
25. Most common lysosomal storage disease is (UHS ANNUAL 2017)
A- Tay sach disease
B- Gaucher s disease
C- Neiman pick disease
D- Fabry disease
E- Both C & D Both
Correct Answer: B
26.Which one of the following is NOT the feature of neimann -pick
disease (UHS ANNUAL 2017)
A- cherry red macula
B- Hepatomegaly
C- Splenomegaly
D- Osteoporosis
E- Purple Red
Correct Answer: D
27.How many ATPS are produced through beta oxidation of Palmitic
Acid (UHS ANNUAL 2017)
A- 126
B- 127
C- 128
D- 129
E- 130
Correct Answer: D
28. Cholestrol stone accounts for over (UHS ANNUAL 2018)
A- 60% cases of cholelithiasis
B- 75%'cases of cholelithiasis
C- 85%'cases of cholelithiasis
D- 95% cases of cholelithiasis
E- C & D Both
Correct Answer: C
29.Tangier s disease is very rare disease which is caused by (UHS
ANNUAL 2018)
A- Defeciency of ABCA1transport protein
B- Defeciency of HPETE ENZYME
C- Defeciency of ABCA 2 transport protein
D- A & C oth
E- None of the above
Correct Answer: A
30.During each cycle of Beta oxidation of FA,all the following
compounds are generated ,except (UHS ANNUAL 2018)
A- NADH
B- H2O
C- FADH2
D- Acyl co A
E- Succinyl CoA
Correct Answer: B
31.Beta oxidation of odd carbon.fatty acid chain produces (UHS
ANNUAL 2018)
A- Succinyl CoA
B- Propionyl Co A
C- Acetyl Co A
D- Malonyl.co A
E- NADPH
Correct Answer: B
32.The lipoprotein with the fastest electrophoretic mobility and the
lowest TG content are(UHS ANNUAL 2019)
A- VLDL
B- IDL
C- HDL
D- LDL
E- Chylomicrons
Correct Answer: C
33.LCAT activity is associated with which of the lipoprotein
complex(UHS ANNUAL 2019)
A- LDL
B- VLDL
C- IDL
D- HDL
E- Chylomicrons
Correct Answer: D
34.Biosynthesis of TG and lecithin both require an intermediate (UHS
ANNUAL 2019)
A- Phosphatidic acid
B- Phosphatidyl ethanolamine
C- Phosphatidyl adenylase
D- Phosphatidyl cytidylate
E- All of the above
Correct Answer: A
35.Brown adipose tissue is characterized by the following (UHS ANNUAL
2019)
A- Present in large quantities in adult humans
B- Mitochondrial.content higher than white adipose tissue
C- Absent in hibernating animals
D- All.of above
E- None
Correct Answer: B
36.A metabolite that is common to pathways of cholestrol biosynthesis
from acetyl Co A and cholecalciferol formation from.cholestrol is (UHS
ANNUAL 2020)
A- Lumisterol
B- Zymosterol
C- Ergosterol
D- 7-Dehydrocholestrol
E- A & C Both
Correct Answer: D
37.Phosphatidylcholine js synthesized from diglycides and choline in
the lungs .An important intermediate in the reaction is (UHS ANNUAL
2021 Held In 2022)
A- Choline adenylate
B- UDP choline
C- CDP choline
D- Choline pyrophosphate
E- All of the above
Correct Answer: C
38.All.of the following statements concerning fatty acids synthesis are
true except that (UHS ANNUAL 2021 Held In 2022)
A- Decarboxylation takes place
B- The reductant is NADPH
C- MOST OF intermediates are.bonded to Co A
D- Carboxylation takes place
E- The Oxidation is NADPH
Correct Answer: C
39.patients with type.2.a hyperlipidemia (hypercholestrolemia)exhibit
(UHS ANNUAL 2021 Held In 2022)
A- A deficiency of lipoprotein lipase
B- A deficiency of LDL receptors
C- Normal .serum cholestrol levels
D- Elevated serum triacylglycerol levels
E- A deficiency of VLDL receptors
Correct Answer: B
40. All of the following are important intermediates in the synthesis of
fatty acids from glucose except (UHS ANNUAL 2021 Held In 2022)
A- Citrate
B- Malonyl.Co A
C- 3 ketoacyl Co A
D- Mitochondrial acetyl Co A
E- Succinyl CoA
Correct Answer: C