Reference Standard Test

Patient History + Skin Test + Drug

Provocation Test
Patients with anaphylaxis Row Totals
Before skin
Negative skin test
testing
Positive
2 0
>0.35 kUA/L 2
Diagnostic Test (True Positive) A (False Positive) B
(CAP-FEIA/ RAST)
Negative
6 4
<0.35 kUA/L 10
(False Negative) C (True Negative) D
Column Totals 8 4 12
SN = A/(A+C) SP = D/(D+B)
= 2/ (2+6) = 4/ (4+0)
= 25% = 100%
LR+
= SN/(1-SP)
LR-
= NO POSSIBLE
= (1-SN)/SP
ANSWER
= 0.75
(imaginary
number)

Reference Standard Test

Patient History + Skin Test + Drug
Provocation Test
Patients with anaphylactic shock Row Totals
Before skin
Negative skin test
testing
Positive
1 2
>0.35 kUA/L 3
Diagnostic Test (True Positive) A (False Positive) B
(CAP-FEIA/ RAST)
Negative
7 2
<0.35 kUA/L 9
(False Negative) C (True Negative) D
Column Totals 8 4 12
SN = A/(A+C) SP = D/(D+B)
= 1/ (1+7) = 2/ (2+2)
= 12.5% = 50%
LR+ LR-
= SN/(1-SP) = (1-SN)/SP
= 0.25 = 1.75
 Reference Standard Test
Patient History + Skin Test + Drug
Patients with anaphylaxis and Provocation Test
Row Totals
anaphylactic shock
Before skin
Negative skin test
testing
Positive
3 1
>0.35 kUA/L 4
Diagnostic Test (True Positive) A (False Positive) B
(CAP-FEIA/ RAST)
Negative
13 7
<0.35 kUA/L 20
(False Negative) C (True Negative) D
Column Totals 16 8 24
SN = A/(A+C) SP = D/(D+B)
= 3/ (3+13) = 7/ (7+1)
= 18.75% = 87.5%
LR+ LR-
= SN/(1-SP) = (1-SN)/SP
= 1.5 =0.929

Table for urticaria cannot be made since there is no 100 specificity that can tell that the patient is in
positive or negative.